ArticleNature communications2022
Design of synthetic collagens that assemble into supramolecular banded fibers as a functional biomaterial testbed.
Article in Nature communications, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
24 citing papers in PubMed, 51 citations in OpenAlex.
- FOS Regulates Myogenic and Adipogenic Differentiation via Extracellular Matrix Signaling.Journal of agricultural and food chemistry · 2026Article
- Free energy of collagen-mimetic peptide dimerization and implications for fibrillization.Biophysical journal · 2026Article
- Photo-Crosslinking Aided Hierarchical Assembly of Recombinant Collagen Hydrogels for 3D Bio-Printing.Biotechnology journal · 2026Article
- Real-time visualization of collagen assembly uncovers metastable properties in hierarchical organization.Nature communications · 2026Article
- Strategies for Optimizing the Yield and Function of Recombinant Collagen in Different Expression Systems: A Review.International journal of molecular sciences · 2026Review
- 3D printed porous tantalum loaded with quercetin-curcumin-piperine PLGA nanoparticles for bone defect repair.Scientific reports · 2026Article
- Dynamic adaptive coassembled sericin protein orchestrating stem cell development for nucleus pulposus regeneration.Science advances · 2026Article
- Recombinant collagen in regenerative medicine: Expression strategies, structural design, and translational applications.Materials today. Bio · 2025Review
- Distinctive fish collagen drives vascular regeneration by polarizing macrophages to M2 phenotype via TNF-α/NF-κB pathway.Materials today. Bio · 2025Article
- Structure and Function of the Extracellular Matrix in Normal and Pathological Conditions: Looking at the Bicuspid Aortic Valve.International journal of molecular sciences · 2025Review
- Discovering novel type I collagen fragments from Cyprinus carpio supporting bone regeneration.Functional & integrative genomics · 2025Article
- A Collagen Triple Helix without the Superhelical Twist.ACS central science · 2025Article
- Fabrication of collagen-based biomaterials for sports medicine application.Regenerative biomaterials · 2025Review
- Recombinant human collagen type III microgel: an advanced injectable dermal filler for rejuvenating aging skin.Regenerative biomaterials · 2025Article
- Identification of a human type XVII collagen fragment with high capacity for maintaining skin health.Synthetic and systems biotechnology · 2024Article
- Exploration of the hierarchical assembly space of collagen-like peptides beyond the triple helix.Nature communications · 2024Article
- Diffusion model assisted designing self-assembling collagen mimetic peptides as biocompatible materials.Briefings in bioinformatics · 2024Article
- Advancing Synthetic Hydrogels through Nature-Inspired Materials Chemistry.Advanced materials (Deerfield Beach, Fla.) · 2024Review
- A Collagen Triple Helix without the Super Helical Twist.bioRxiv : the preprint server for biology · 2024Article
- Selective Excitation of theACS omega · 2024Article
Corrections and comments
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Authors and funding
11 authors at 3 institutions in 2 countries.
Funding
Abstract
Collagens are the most abundant proteins of the extracellular matrix, and the hierarchical folding and supramolecular assembly of collagens into banded fibers is essential for mediating cell-matrix interactions and tissue mechanics. Collagen extracted from animal tissues is a valuable commodity, but suffers from safety and purity issues, limiting its biomaterials applications. Synthetic collagen biomaterials could address these issues, but their construction requires molecular-level control of folding and supramolecular assembly into ordered banded fibers, comparable to those of natural collagens. Here, we show an innovative class of banded fiber-forming synthetic collagens that recapitulate the morphology and some biological properties of natural collagens. The synthetic collagens comprise a functional-driver module that is flanked by adhesive modules that effectively promote their supramolecular assembly. Multiscale simulations support a plausible molecular-level mechanism of supramolecular assembly, allowing precise design of banded fiber morphology. We also experimentally demonstrate that synthetic fibers stimulate osteoblast differentiation at levels comparable to natural collagen. This work thus deepens understanding of collagen biology and disease by providing a ready source of safe, functional biomaterials that bridge the current gap between the simplicity of peptide biophysical models and the complexity of in vivo animal systems.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.