Evidence map›Paper›PMID 36351900›Full record

ArticleNature communications2022

An allosteric modulator activates BK channels by perturbing coupling between Ca

Guohui Zhang, Xianjin Xu, Zhiguang Jia, Yanyan Geng, Hongwu Liang, Jingyi Shi, Martina Marras, Carlota Abella, Karl L Magleby, Jonathan R Silva and 3 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nature communications, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
  4. Review
  5. Article
  6. Article
  7. Article
  8. Article
  9. Redox-dependent CdBiophysical journal · 2024
    Article
  10. Review
  11. Article
  12. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Guohui Zhang *Department of Biomedical Engineering, Center for the Investigation of Membrane Excitability Disorders, Cardiac Bioelectricity and Arrhythmia Center, Washington University, St. Louis, MO, USA.ORCID 0000-0001-6905-0637
Xianjin Xu *Dalton Cardiovascular Research Center, University of Missouri - Columbia, Columbia, MO, USA.
Zhiguang Jia *Department of Chemistry, University of Massachusetts, Amherst, MA, USA.
Yanyan GengDepartment of Physiology and Biophysics, University of Miami Miller School of Medicine, Miami, FL, USA.
Hongwu LiangDepartment of Biomedical Engineering, Center for the Investigation of Membrane Excitability Disorders, Cardiac Bioelectricity and Arrhythmia Center, Washington University, St. Louis, MO, USA.
Jingyi ShiDepartment of Biomedical Engineering, Center for the Investigation of Membrane Excitability Disorders, Cardiac Bioelectricity and Arrhythmia Center, Washington University, St. Louis, MO, USA.
Martina MarrasDepartment of Biomedical Engineering, Center for the Investigation of Membrane Excitability Disorders, Cardiac Bioelectricity and Arrhythmia Center, Washington University, St. Louis, MO, USA.ORCID 0000-0001-6740-3806
Carlota AbellaDepartment of Biomedical Engineering, Center for the Investigation of Membrane Excitability Disorders, Cardiac Bioelectricity and Arrhythmia Center, Washington University, St. Louis, MO, USA.
Karl L MaglebyDepartment of Physiology and Biophysics, University of Miami Miller School of Medicine, Miami, FL, USA.
Jonathan R SilvaDepartment of Biomedical Engineering, Center for the Investigation of Membrane Excitability Disorders, Cardiac Bioelectricity and Arrhythmia Center, Washington University, St. Louis, MO, USA. jonsilva@wustl.edu.ORCID 0000-0002-3696-3955
Jianhan ChenDepartment of Chemistry, University of Massachusetts, Amherst, MA, USA. jianhanc@umass.edu.ORCID 0000-0002-5281-1150
Xiaoqin ZouDalton Cardiovascular Research Center, University of Missouri - Columbia, Columbia, MO, USA. zoux@missouri.edu.ORCID 0000-0003-0637-8648
Jianmin CuiDepartment of Biomedical Engineering, Center for the Investigation of Membrane Excitability Disorders, Cardiac Bioelectricity and Arrhythmia Center, Washington University, St. Louis, MO, USA. jcui@wustl.edu.ORCID 0000-0002-9198-6332

Funding

Structure prediction and in silico screening of protein-peptide interactionsR35GM136409 · NIGMS · UNIVERSITY OF MISSOURI-COLUMBIA · PI XIAOQIN ZOU · 2020 to 2026
$2.9M
Mechanism of BK Channel GatingR01HL142301 · NHLBI · WASHINGTON UNIVERSITY · PI SILVA, JONATHAN R · 2018 to 2021
$2.9M
Disordered Proteins and Dynamic Interactions in Biology and Diseases.R35GM144045 · NIGMS · UNIVERSITY OF MASSACHUSETTS AMHERST · PI Jianhan Chen · 2022 to 2026
$2.0M
NHLBI NIH HHS R01 HL142301NIGMS NIH HHS R35 GM136409NIGMS NIH HHS R35 GM144045
6 · The paper itself

Abstract

BK type Ca

Indexed as

CalciumLarge-Conductance Calcium-Activated Potassium ChannelsCell MembraneCalciumLarge-Conductance Calcium-Activated Potassium Channels

Identifiers

PMID36351900
PMCPMC9646747

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.