ArticleExperimental neurobiology2022
Reduced Sulcal Depth in Central Sulcus of Major Depressive Disorder.
Article in Experimental neurobiology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed, 21 citations in OpenAlex.
- Influence of sex and systemic lupus erythematosus disease status on cerebral cortex structure.Lupus science & medicine · 2026Trial
- Personalized Estimates of Brain Cortical Structural Similarity in Major Depressive Disorder: Evidence from a Multi-Site Neuroimaging Dataset.Diagnostics (Basel, Switzerland) · 2026Article
- How do infant brains fold? Sulcal deepening is linked to development of sulcal span, thickness, curvature, and microstructure.Communications biology · 2026Article
- Cortical folding pattern of asymptomatic HIV-associated neurocognitive disorders.BMC medical imaging · 2025Article
- Alterations in sulcal depth and associated functional connectivity in schizophrenia with auditory verbal hallucinations.Frontiers in psychiatry · 2025Article
- Brain network predictors of changes in symptoms and serum BDNF following antidepressant treatment with escitalopram and Yueju Pill in major depressive disorder: a randomised, double-blind, placebo-controlled pilot study.General psychiatry · 2025Article
- Differences in structural brain morphometry between musicians and non-musicians.Frontiers in human neuroscience · 2025Article
- Partitioning variance in cortical morphometry into genetic, environmental, and subject-specific components.Cerebral cortex (New York, N.Y. : 1991) · 2024Article
- Cerebral Cortical Surface Structure and Neural Activation Pattern Among Adolescent Football Players.JAMA network open · 2024Article
- Changed cortical thickness and sulcal depth in pediatric acute lymphoblastic leukemia survivors treated with chemotherapy only.Brain imaging and behavior · 2023Article
- On presentation of the human cerebral sulci from inside of the cerebrum.Journal of anatomy · 2023Article
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Major depressive disorder (MDD) is one of the most common psychiatric disorders, and present various symptoms such as the dysregulation of mood, cognition, and behavior. The purpose of the present study was to investigate the morphometric change in MDD patients by voxel-based morphometry (VBM) and sulcal depth analyses. Forty-six MDD patients (mean age, SD; 36.07±14.34), and 23 age- and sex-matched normal controls (NML) (mean age, SD; 36.78±14.42) were included. Coronal 3D T1 magnetic resonance imaging (MRI) was obtained with the resolution of isotropic 1.0 mm. To check morphological changes of brain, T1 MRIs were objectively processed by VBM and sulcal depth methods. In sulcal depth analysis, depressed patients showed reduced sulcal depth in the areas of left posterior ramus of the lateral sulcus, superior frontal sulcus, supramarginal gyrus, central sulcus (Rolando's fissure), and Heschl's gyrus. And right posterior ramus of the lateral sulcus, temporal plane of the superior temporal gyrus, anterior transverse collateral sulcus, and central sulcus (Rolando's fissure) were also reduced compared to NML. But, VBM analyses did not showed significant finding. Reduced sulcal depth in the motor and emotion related areas were found in patients with MDD. Especially reduced sulcal depth in bilateral central sulci which are connecting between primary motor cortex and primary sensory cortex seems to be related with social and physical anhedonia in MDD.
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