ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2022
Neural Mechanisms Mediating Sex Differences in Motivation for Reward: Cognitive Bias, Food, Gambling, and Drugs of Abuse.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 24 citations in OpenAlex.
- Sex-biased computations underlying differential set shift performance in mice.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2026Article
- Disruption of psychostimulant-associated memories by single, low dose ketamine in rats.Neuropharmacology · 2026Article
- Neuromodulator Dynamics Underlying Associative Learning in the Ventral Striatum's Olfactory Tubercle.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Astrocytic CREB regulates transcriptomic, neuronal, and behavioral responses to cocaine.Science advances · 2025Article
- Effects of Audiovisual Cues on Game Immersion during Simulated Slot Machine Gambling.Journal of gambling studies · 2025Article
- The Validation of the Persian Version of Sugar Addiction Questionnaire: Factor Structure, Item Analysis and Model Fit.Iranian journal of psychiatry · 2025Article
- Sex differences in motivational biases over instrumental actions.NPJ science of learning · 2024Article
- Insular cortex subregions have distinct roles in cued heroin seeking after extinction learning and prolonged withdrawal in rats.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2024Article
- Choice impulsivity after repeated social stress is associated with increased perineuronal nets in the medial prefrontal cortex.Scientific reports · 2024Article
- Voluntary wheel running access produces opposite effects in male and female rats on both palatable diet consumption and associated ventral striatal opioid- and dopamine-related gene expression.Frontiers in integrative neuroscience · 2024Article
- Assessing gender differences in food preferences and physical activity: a population-based survey.Frontiers in nutrition · 2024Article
- Ethanol-Induced Suppression of G Protein-Gated Inwardly Rectifying KBiological psychiatry · 2023Article
- Still a "hidden island"? The rodent insular cortex in drug seeking, reward, and risk.Neuroscience and biobehavioral reviews · 2023Review
- Applying behavioral economics-based approaches to examine the effects of liquid sucrose consumption on motivation.Appetite · 2023Article
- Biological and Clinical Implications of Sex-Specific Differences in Alzheimer's Disease.Handbook of experimental pharmacology · 2023Review
Corrections and comments
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Authors and funding
6 authors at 6 institutions in 2 countries.
Funding
Abstract
Sex differences in motivation for food rewards, gambling, and drugs of abuse are modulated by multiple factors, including sensory stimuli, gonadal hormones, and cognitive bias. Cues, drugs of abuse, and a high-fat diet can significantly impact neural signaling in the reward system and functioning of neural systems that regulate executive functions differentially in males and females. Additionally, sex differences in risky decision-making, cognitive bias, and motivation for food and drugs of abuse are mediated by gonadal hormones in both sexes. As neuroscientists analyze data from both sexes, it is becoming apparent that these differences are not simply mediated by hormones in females, but involve sex differences in the specific neural responses to stimuli, including both external stimuli and internal hormonal signals. Understanding sex differences in the mechanisms underlying reward-seeking behaviors and the development of substance use disorders will help uncover potential therapies and treatments that will benefit both men and women. Based on these observations, it is essential that females are included in neuroscience research.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.