Evidence map›Paper›PMID 36351825›Full record

ReviewThe Journal of neuroscience : the official journal of the Society for Neuroscience2022

Music and Brain Circuitry: Strategies for Strengthening Evidence-Based Research for Music-Based Interventions.

Wen Grace Chen, John Rehner Iversen, Mimi H Kao, Psyche Loui, Aniruddh Dhiren Patel, Robert J Zatorre, Emmeline Edwards

2 registry-linked trialsAbstract readReview
In one paragraph

Review in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 40 papers, 5 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
40citing papers in PubMed, 5 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06706778 nanot yet recruitingnot on this mapstarted 2026, after this paper: background citation

Impacts of Music-based Intervention on Pain in Individuals With Irritable Bowel Syndrome (IBS): A Mechanistic Pilot Study

TypeinterventionalSponsorYale UniversityRan2026 to 2027Enrolled30ConditionsAbdominal Pain/ Discomfort, Irritable Bowel SyndromeArmsMusic intervention
NCT07544602 not yet recruitingnot on this mapstarted 2026, after this paper: background citation

Music Therapy for Comatose Brain Injured Patients

Typeobservational_patient_registrySponsorMercy Health OhioRan2026 to 2028Enrolled35ConditionsTraumatic Brain Injury
3 · Its place in the literature

Who cites it

40 citing papers in PubMed, 5 syntheses or guidelines pooled it.

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  10. Listening to a Consonant Chord Progression during Live Face-to-Face Gaze Enhances Neural Activity in Social Systems.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Wen Grace ChenDivision of Extramural Research, National Center for Complementary and Integrative Health, National Institutes of Health, Bethesda, Maryland, 20892.
John Rehner IversenUniversity of California-San Diego, La Jolla, California 92093.ORCID 0000-0002-4172-9848
Mimi H KaoTufts University, Medford, Massachusetts 02155.ORCID 0000-0001-8884-9022
Psyche LouiNortheastern University, Boston, Massachusetts 02115.ORCID 0000-0001-7664-6092
Aniruddh Dhiren PatelTufts University, Medford, Massachusetts 02155.ORCID 0000-0003-2229-9341
Robert J ZatorreMontreal Neurological Institute, McGill University, Montreal, Quebec H3A2B4, Canada.
Emmeline EdwardsDivision of Extramural Research, National Center for Complementary and Integrative Health, National Institutes of Health, Bethesda, Maryland, 20892 emmeline.edwards@nih.gov.ORCID 0000-0003-0500-8741

Funding

Gamma-Music Based Intervention for Mild Alzheimer's DiseaseR01AG078376 · NIA · NORTHEASTERN UNIVERSITY · PI Edward W Large, Psyche Loui · 2022 to 2026
$2.7M
Large-scale nested studies of the impact of music on brain and behavioral developmentR01AA028411 · NIAAA · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI IVERSEN, JOHN REHNER · 2019 to 2021
$825k
SynchronyGamma: A Music-Based Intervention for Alzheimer's and Mild Cognitive ImpairmentR43AG078012 · NIA · OSCILLOSCAPE, LLC · PI LARGE, EDWARD W, LOUI, PSYCHE · 2022 to 2022
$450k
NIAAA NIH HHS R01 AA028411NIA NIH HHS R01 AG078376NIA NIH HHS R43 AG078012
6 · The paper itself

Abstract

The neuroscience of music and music-based interventions (MBIs) is a fascinating but challenging research field. While music is a ubiquitous component of every human society, MBIs may encompass listening to music, performing music, music-based movement, undergoing music education and training, or receiving treatment from music therapists. Unraveling the brain circuits activated and influenced by MBIs may help us gain better understanding of the therapeutic and educational values of MBIs by gathering strong research evidence. However, the complexity and variety of MBIs impose unique research challenges. This article reviews the recent endeavor led by the National Institutes of Health to support evidence-based research of MBIs and their impact on health and diseases. It also highlights fundamental challenges and strategies of MBI research with emphases on the utilization of animal models, human brain imaging and stimulation technologies, behavior and motion capturing tools, and computational approaches. It concludes with suggestions of basic requirements when studying MBIs and promising future directions to further strengthen evidence-based research on MBIs in connections with brain circuitry.

Indexed as

MusicNeurosciencesAnimalsAuditory PerceptionBrainHumansRewardbrain circuitsmusical componentsmusic-based interventionstechnologiestherapeutic effects

Identifiers

PMID36351825
PMCPMC9665917

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.