Evidence map›Paper›PMID 36351817›Full record

ArticleeNeuro

The Developmental Progression of Eight Opsin Spectral Signals Recorded from the Zebrafish Retinal Cone Layer Is Altered by the Timing and Cell Type Expression of Thyroxin Receptor β2 (trβ2) Gain-Of-Function Transgenes.

Ralph F Nelson, Annika Balraj, Tara Suresh, Leah J Elias, Takeshi Yoshimatsu, Sara S Patterson

Open access · goldAbstract read
In one paragraph

Article in eNeuro. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
0.9field-weighted citation impact, top 28% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 10 citations in OpenAlex.

  1. Review
  2. Article
  3. Review
  4. Article
  5. Cone photoreceptor differentiation regulated by thyroid hormone transporter MCT8 in the retinal pigment epithelium.Proceedings of the National Academy of Sciences of the United States of America · 2024
    Article
  6. Review
  7. Article
  8. Review
  9. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Ralph F NelsonNational Institute of Neurological Disorders and Stroke, National Institutes of Health, Rockville, MD 20892 nelsonr@ninds.nih.gov.
Annika BalrajNational Institute of Neurological Disorders and Stroke, National Institutes of Health, Rockville, MD 20892.
Tara SureshNational Institute of Neurological Disorders and Stroke, National Institutes of Health, Rockville, MD 20892.ORCID https://orcid.org/0000-0003-0226-7182
Leah J EliasNational Institute of Neurological Disorders and Stroke, National Institutes of Health, Rockville, MD 20892.ORCID https://orcid.org/0000-0002-8613-7977
Takeshi YoshimatsuDepartment of Biological Structure, University of Washington, Seattle, WA 98195.
Sara S PattersonNational Institute of Neurological Disorders and Stroke, National Institutes of Health, Rockville, MD 20892.ORCID https://orcid.org/0000-0003-4574-3935
National Institutes of Health · USUniversity of Washington · US

Funding

Structure And Function In Retinal NeuronsZIANS002631 · NINDS · NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE · PI NELSON, RALPH F · 2009 to 2023
$6.6M
Intramural NIH HHS ZIA NS002631
6 · The paper itself

Abstract

Zebrafish retinal cone signals shift in spectral shape through larval, juvenile, and adult development as expression patterns of eight cone-opsin genes change. An algorithm extracting signal amplitudes for the component cone spectral types is developed and tested on two thyroxin receptor β2 (trβ2) gain-of-function lines

Indexed as

Retinal Cone Photoreceptor CellsZebrafishAnimalsAnimals, Genetically ModifiedGain of Function MutationLarvaOpsinsReceptors, Thyroid HormoneRod OpsinsThyroxineTransgenesOpsinsReceptors, Thyroid HormoneRod OpsinsThyroxinedevelopmental biologyERGopsin absorbanceopsin antibodiesred conesspectral sensitivity

Identifiers

PMID36351817
PMCPMC9718360
OpenAlexW4308623208

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.