ArticleCell reports2022
Stable, interactive modulation of neuronal oscillations produced through brain-machine equilibrium.
Article in Cell reports, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 35 citations in OpenAlex.
- Brain-Computer Interfaces: The Dawn of a New Era in Disease Treatment.Exploration (Beijing, China) · 2026Review
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- An Adaptable Phase-Tracking System for Parkinsonian Rest Tremor: Design and In-Clinic Feasibility.IEEE journal of translational engineering in health and medicine · 2025Article
- Beta bursts in the parkinsonian cortico-basal ganglia network form spatially discrete ensembles.Neurobiology of disease · 2024Article
- Organizing the coactivity structure of the hippocampus from robust to flexible memory.Science (New York, N.Y.) · 2024Article
- How to design optimal brain stimulation to modulate phase-amplitude coupling?Journal of neural engineering · 2024Article
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- Deep brain stimulation pulse sequences to optimally modulate frequency-specific neural activity.Journal of neural engineering · 2024Article
- Cortical signatures of sleep are altered following effective deep brain stimulation for depression.Translational psychiatry · 2024Article
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- Closing the loop in psychiatric deep brain stimulation: physiology, psychometrics, and plasticity.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2024Review
- Open Hardware Implementation of Real-Time Phase and Amplitude Estimation for Neurophysiologic Signals.Bioengineering (Basel, Switzerland) · 2023Article
- Different Methods to Estimate the Phase of Neural Rhythms Agree But Only During Times of Low Uncertainty.eNeuro · 2023Article
- Different methods to estimate the phase of neural rhythms agree, but only during times of low uncertainty.bioRxiv : the preprint server for biology · 2023Article
- Approaches to characterizing oscillatory burst detection algorithms for electrophysiological recordings.Journal of neuroscience methods · 2023Article
- Stimulating at the right time to recover network states in a model of the cortico-basal ganglia-thalamic circuit.PLoS computational biology · 2022Article
- Phase-dependent closed-loop deep brain stimulation of the fornix provides bidirectional manipulation of hippocampal theta oscillations.Brain stimulationArticle
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Closed-loop interaction has the potential to regulate ongoing brain activity by continuously binding an external stimulation to specific dynamics of a neural circuit. Achieving interactive modulation requires a stable brain-machine feedback loop. Here, we demonstrate that it is possible to maintain oscillatory brain activity in a desired state by delivering stimulation accurately aligned with the timing of each cycle. We develop a fast algorithm that responds on a cycle-by-cycle basis to stimulate basal ganglia nuclei at predetermined phases of successive cortical beta cycles in parkinsonian rats. Using this approach, an equilibrium emerges between the modified brain signal and feedback-dependent stimulation pattern, leading to sustained amplification or suppression of the oscillation depending on the phase targeted. Beta amplification slows movement speed by biasing the animal's mode of locomotion. Together, these findings show that highly responsive, phase-dependent stimulation can achieve a stable brain-machine interaction that leads to robust modulation of ongoing behavior.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.