Evidence map›Paper›PMID 36351394›Full record

ArticleCell reports2022

Tuft-cell-intrinsic and -extrinsic mediators of norovirus tropism regulate viral immunity.

Madison S Strine, Mia Madel Alfajaro, Vincent R Graziano, Jaewon Song, Leon L Hsieh, Ryan Hill, Jun Guo, Kelli L VanDussen, Robert C Orchard, Megan T Baldridge and 2 more

Open access · goldAbstract read
In one paragraph

Article in Cell reports, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.

0numbers the graph read from it
0cells of the map it votes in
26citing papers in PubMed
2.7field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

26 citing papers in PubMed, 28 citations in OpenAlex.

  1. Plscr1 inhibits murine norovirus entry.bioRxiv : the preprint server for biology · 2026
    Article
  2. Article
  3. Article
  4. Article
  5. Article
  6. Review
  7. Article
  8. Review
  9. Review
  10. Article
  11. Article
  12. Article
  13. Review
  14. Review
  15. Article
  16. Tuft cells in the intestine, immunity and beyond.Nature reviews. Gastroenterology & hepatology · 2024
    Review
  17. Article
  18. Article
  19. Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 7 institutions in 1 country.

Madison S StrineDepartment of Immunobiology, Yale University School of Medicine, New Haven, CT, USA; Department of Laboratory Medicine, Yale University School of Medicine, New Haven, CT, USA.
Mia Madel AlfajaroDepartment of Immunobiology, Yale University School of Medicine, New Haven, CT, USA; Department of Laboratory Medicine, Yale University School of Medicine, New Haven, CT, USA.
Vincent R GrazianoDepartment of Immunology, University of Connecticut Health Center, Farmington, CT, USA.
Jaewon SongDepartment of Molecular Microbiology and Immunology, Brown University, Providence, RI, USA.
Leon L HsiehDepartment of Molecular Microbiology and Immunology, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, MD, USA.
Ryan HillDivision of Infectious Diseases, Department of Medicine, Edison Family Center for Genome Sciences & Systems Biology, Washington University School of Medicine, St. Louis, MO, USA.
Jun GuoDepartment of Surgery, Washington University School of Medicine, Saint Louis, MO, USA.
Kelli L VanDussenDepartment of Pediatrics, Cincinnati Children's Hospital Medical Center and University of Cincinnati, Cincinnati, OH, USA.
Robert C OrchardDepartment of Immunology, University of Texas Southwestern Medical School, Dallas, TX, USA.
Megan T BaldridgeDepartment of Medicine, Division of Infectious Diseases, Edison Family Center for Genome Sciences & Systems Biology, Washington University School of Medicine, Saint Louis, MO, USA.
Sanghyun LeeDepartment of Molecular Microbiology and Immunology, Brown University, Providence, RI, USA. Electronic address: sanghyun_lee@brown.edu.
Craig B WilenDepartment of Immunobiology, Yale University School of Medicine, New Haven, CT, USA; Department of Laboratory Medicine, Yale University School of Medicine, New Haven, CT, USA. Electronic address: craig.wilen@yale.edu.
Washington University in St. Louis · USYale University · USBrown University · USCincinnati Children's Hospital Medical Center · USJohns Hopkins University · USThe University of Texas Southwestern Medical Center · USUConn Health · US

Funding

The role of tuft cells in norovirus pathogenesisR01AI148467 · NIAID · YALE UNIVERSITY · PI Craig Brian Wilen · 2020 to 2026
$3.9M
Role of CD300 Family in Norovirus Tropism, Persistence, and ImmunityR01AI127552 · NIAID · WASHINGTON UNIVERSITY · PI BALDRIDGE, MEGAN T, FREMONT, DAVED H. · 2017 to 2021
$3.5M
Norovirus regulation via bacterial modulation of interferon-lambdaR01AI139314 · NIAID · WASHINGTON UNIVERSITY · PI BALDRIDGE, MEGAN T · 2019 to 2023
$2.0M
Role of virus-receptor interactions in determining norovirus tropism and pathogenesis in vivoK08AI128043 · NIAID · YALE UNIVERSITY · PI WILEN, CRAIG BRIAN · 2017 to 2021
$940k
Identification and Characterization of Norovirus Cofactors for EntryR00DK116666 · NIDDK · UT SOUTHWESTERN MEDICAL CENTER · PI ORCHARD, ROBERT C. · 2018 to 2020
$747k
A Secreted Viral Protein Determines Norovirus Persistence By Immune EvasionR00AI141683 · NIAID · BROWN UNIVERSITY · PI LEE, SANGHYUN · 2020 to 2021
$493k
NIAID NIH HHS K08 AI128043NIAID NIH HHS R00 AI141683NIAID NIH HHS R01 AI127552NIAID NIH HHS R01 AI139314NIAID NIH HHS R01 AI148467NIDDK NIH HHS R00 DK116666
6 · The paper itself

Abstract

Murine norovirus (MNoV) is a model for human norovirus and for interrogating mechanisms of viral tropism and persistence. We previously demonstrated that the persistent strain MNoV

Indexed as

Caliciviridae InfectionsNorovirusAnimalsHumansMiceMice, Inbred C57BLTropismViral TropismCP: ImmunologyCP: Microbiologyimmune evasioninterferonmucosal immunitynorovirustuft cellsviral persistenceviral tropism

Identifiers

PMID36351394
PMCPMC9662704
OpenAlexW4308515321

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.