Evidence map›Paper›PMID 36351335›Full record

ArticleJournal of the National Comprehensive Cancer Network : JNCCN2022

NCCN Guidelines® Insights: Gastrointestinal Stromal Tumors, Version 2.2022.

Margaret von Mehren, John M Kane, Richard F Riedel, Jason K Sicklick, Seth M Pollack, Mark Agulnik, Marilyn M Bui, Janai Carr-Ascher, Edwin Choy, Mary Connelly and 24 more

Open access · bronzeAbstract read
In one paragraph

Article in Journal of the National Comprehensive Cancer Network : JNCCN, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 77 papers.

0numbers the graph read from it
0cells of the map it votes in
77citing papers in PubMed
17.5field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

77 citing papers in PubMed, 114 citations in OpenAlex.

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  18. EndoscopicWorld journal of gastrointestinal oncology · 2026
    Article
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17 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

34 authors at 20 institutions in 3 countries.

Margaret von Mehren1Fox Chase Cancer Center.
John M Kane2Roswell Park Comprehensive Cancer Center.
Richard F Riedel3Duke Cancer Institute.
Jason K Sicklick4UC San Diego Moores Cancer Center.
Seth M Pollack5Robert H. Lurie Comprehensive Cancer Center of Northwestern University.
Mark Agulnik6City of Hope National Medical Center.
Marilyn M Bui7Moffitt Cancer Center.
Janai Carr-Ascher8UC Davis Comprehensive Cancer Center.
Edwin Choy9Massachusetts General Hospital Cancer Center.
Mary Connelly10The Ohio State University Comprehensive Cancer Center - James Cancer Hospital and Solove Research Institute.
Sarah Dry11UCLA Jonsson Comprehensive Cancer Center.
Kristen N Ganjoo12Stanford Cancer Institute.
Ricardo J Gonzalez7Moffitt Cancer Center.
Ashley Holder13O'Neal Comprehensive Cancer Center at UAB.
Jade Homsi14UT Southwestern Simmons Comprehensive Cancer Center.
Vicki Keedy15Vanderbilt-Ingram Cancer Center.
Ciara M Kelly16Memorial Sloan Kettering Cancer Center.
Edward Kim17Fred Hutchinson Cancer Center.
David Liebner10The Ohio State University Comprehensive Cancer Center - James Cancer Hospital and Solove Research Institute.
Martin McCarter18University of Colorado Cancer Center.
Sean V McGarry19Fred & Pamela Buffett Cancer Center.
Nathan W Mesko20Case Comprehensive Cancer Center/University Hospitals Seidman Cancer Center and Cleveland Clinic Taussig Cancer Institute.
Christian Meyer21The Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins.
Alberto S Pappo22St. Jude Children's Research Hospital/University of Tennessee Health Science Center.
Amanda M Parkes23University of Wisconsin Carbone Cancer Center.
Ivy A Petersen24Mayo Clinic Cancer Center.
Matthew Poppe25Huntsman Cancer Institute at the University of Utah.
Scott Schuetze26University of Michigan Rogel Cancer Center.
Jacob Shabason27Abramson Cancer Center at the University of Pennsylvania.
Matthew B Spraker28Siteman Cancer Center at Barnes-Jewish Hospital and Washington University School of Medicine.
Melissa Zimel29UCSF Helen Diller Family Comprehensive Cancer Center; and.
Mary Anne Bergman30National Comprehensive Cancer Network.
Hema Sundar30National Comprehensive Cancer Network.
Lisa E Hang30National Comprehensive Cancer Network.
National Comprehensive Cancer NetworkCancer Institute (WIA) · INMoffitt Cancer Center · USThe Ohio State University Comprehensive Cancer Center – Arthur G. James Cancer Hospital and Richard J. Solove Research Institute · USUniversity of Colorado Denver · USCity Of Hope National Medical Center · USFox Chase Cancer Center · USFred and Pamela Buffett Cancer CenterFred Hutch Cancer Center · USHarold C. Simmons Comprehensive Cancer CenterHuntsman Cancer Institute · USJewish Hospital · USKettering University · USMassachusetts General Hospital · USMoores Cancer CenterO'Neal Comprehensive Cancer CenterRobert H. Lurie Comprehensive Cancer Center of Northwestern UniversitySidney Kimmel Comprehensive Cancer Center · USStanford Cancer InstituteUCSF Helen Diller Family Comprehensive Cancer Center · US

Funding

Targeting Drug-Resistant Cancer Stem Cell Niches of Gastrointestinal Stromal TumorR01CA226803 · NCI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI SICKLICK, JASON KEITH · 2019 to 2023
$2.1M
NCI NIH HHS R01 CA226803
6 · The paper itself

Abstract

Gastrointestinal stromal tumors (GIST) are the most common type of soft tissue sarcoma that occur throughout the gastrointestinal tract. Most of these tumors are caused by oncogenic activating mutations in the KIT or PDGFRA genes. The NCCN Guidelines for GIST provide recommendations for the diagnosis, evaluation, treatment, and follow-up of patients with these tumors. These NCCN Guidelines Insights summarize the panel discussion behind recent important updates to the guidelines, including revised systemic therapy options for unresectable, progressive, or metastatic GIST based on mutational status, and updated recommendations for the management of GIST that develop resistance to specific tyrosine kinase inhibitors.

Indexed as

Gastrointestinal Stromal TumorsHumansMutationProto-Oncogene Proteins c-kitReceptor, Platelet-Derived Growth Factor alphaProto-Oncogene Proteins c-kitReceptor, Platelet-Derived Growth Factor alpha

Identifiers

PMID36351335
PMCPMC10245542
OpenAlexW4308771341

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.