Evidence map›Paper›PMID 36351255›Full record

ArticleBioEssays : news and reviews in molecular, cellular and developmental biology2023

From correlation to causation: The new frontier of transgenerational epigenetic inheritance.

Mohd Hafiz Rothi, Eric Lieberman Greer

Open access · greenAbstract read
In one paragraph

Article in BioEssays : news and reviews in molecular, cellular and developmental biology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
1.1field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 15 citations in OpenAlex.

  1. Seven wonders of RNA modification biology.RNA (New York, N.Y.) · 2026
    Review
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  11. Shaping eukaryotic epigenetic systems by horizontal gene transfer.BioEssays : news and reviews in molecular, cellular and developmental biology · 2023
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 2 institutions in 1 country.

Mohd Hafiz RothiDepartment of Pediatrics, HMS Initiative for RNA Medicine, Harvard Medical School, Boston, Massachusetts, USA.
Eric Lieberman GreerDepartment of Pediatrics, HMS Initiative for RNA Medicine, Harvard Medical School, Boston, Massachusetts, USA.
Boston Children's Hospital · USHarvard University · US

Funding

Characterization of DNA N6-methyl adenine and its role in epigenetic memoryDP2AG055947 · NIA · BOSTON CHILDREN'S HOSPITAL · PI GREER, ERIC LIEBERMAN · 2016 to 2021
$3.2M
NIA NIH HHS DP2 AG055947
6 · The paper itself

Abstract

While heredity is predominantly controlled by what deoxyribonucleic acid (DNA) sequences are passed from parents to their offspring, a small but growing number of traits have been shown to be regulated in part by the non-genetic inheritance of information. Transgenerational epigenetic inheritance is defined as heritable information passed from parents to their offspring without changing the DNA sequence. Work of the past seven decades has transitioned what was previously viewed as rare phenomenology, into well-established paradigms by which numerous traits can be modulated. For the most part, studies in model organisms have correlated transgenerational epigenetic inheritance phenotypes with changes in epigenetic modifications. The next steps for this field will entail transitioning from correlative studies to causal ones. Here, we delineate the major molecules that have been implicated in transgenerational epigenetic inheritance in both mammalian and non-mammalian models, speculate on additional molecules that could be involved, and highlight some of the tools which might help transition this field from correlation to causation.

Indexed as

HeredityDNA MethylationEpigenesis, GeneticEpigenomicsInheritance PatternsPhenotypeDNA methylationepigenetic inheritancehistone modificationslipid methylationnon-coding RNAsrRNA methylationtransgenerational

Identifiers

PMID36351255
PMCPMC9772138
OpenAlexW4308683396

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.