Evidence map›Paper›PMID 36350997›Full record

ArticleEuropace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology2023

Combined atrial fibrillation ablation and left atrial appendage occlusion procedure in the United States: a propensity score matched analysis from 2016-2019 national readmission database.

Deepak Kumar Pasupula, Sudeep K Siddappa Malleshappa, Muhammad B Munir, Anusha Ganapati Bhat, Antony Anandaraj, Avaneesh Jakkoju, Michael Spooner, Ketan Koranne, Jonathan C Hsu, Brian Olshansky and 1 more

Open access · hybridAbstract read
In one paragraph

Article in Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed
3.3field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed, 22 citations in OpenAlex.

  1. Article
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  3. Efficacy and safety of concomitant catheter ablation and left atrial appendage closure compared to catheter ablation only - a meta-analysis.Journal of interventional cardiac electrophysiology : an international journal of arrhythmias and pacing · 2026
    Article
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  6. Three-year clinical outcomes of left atrial appendage occlusion with or without ablation: insight from the RECORD study.Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology · 2026
    Observational
  7. Review
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  9. Quantitative considerations for choosing between Amulet and Watchman FLX and management of device related complications.Journal of interventional cardiac electrophysiology : an international journal of arrhythmias and pacing · 2025
    Article
  10. Article
  11. Article
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  15. Practical guide on left atrial appendage closure for the non-implanting physician: an international consensus paper.Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology · 2024
    Article
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  18. Three-dimensional intracardiac echocardiography for left atrial appendage sizing and percutaneous occlusion guidance.Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology · 2023
    Article
  19. Prognostic value of chronic kidney disease in patients undergoing left atrial appendage occlusion.Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology · 2023
    Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 7 institutions in 2 countries.

Deepak Kumar PasupulaDivision of Cardiovascular Disease, Department of Internal Medicine, MercyOne North Iowa Medical Center, 1000 4th St SW, Mason City, IA 50401, USA.ORCID 0000-0002-7780-1047
Sudeep K Siddappa MalleshappaDivision of Haematology-Oncology, Department of Internal Medicine, UMass Chan-Baystate, 759 Chestnut St, Springfield, MA 01199, USA.ORCID 0000-0002-2850-5794
Muhammad B MunirDivision of Cardiology, Department of Internal Medicine, University of California Davis, 4150 V Street, Suite 3100, Sacramento, CA 95817, USA.ORCID 0000-0002-9804-898X
Anusha Ganapati BhatDepartment of Cardiology, Department of Internal Medicine, University of Maryland, 620 W Lexington St, Baltimore, MD 21201, USA.ORCID 0000-0002-6967-0171
Antony AnandarajDivision of Cardiovascular Disease, Department of Internal Medicine, MercyOne North Iowa Medical Center, 1000 4th St SW, Mason City, IA 50401, USA.ORCID 0000-0001-6806-4308
Avaneesh JakkojuDivision of Cardiology, Cardiovascular Institute of South, 441 Heymann Blvd, Lafayette, LA 70503, USA.ORCID 0000-0002-7988-9636
Michael SpoonerDivision of Cardiovascular Disease, Department of Internal Medicine, MercyOne North Iowa Medical Center, 1000 4th St SW, Mason City, IA 50401, USA.ORCID 0000-0003-3769-6008
Ketan KoranneDivision of Cardiovascular Disease, Department of Internal Medicine, MercyOne North Iowa Medical Center, 1000 4th St SW, Mason City, IA 50401, USA.
Jonathan C HsuDivision of Cardiology, Department of Internal Medicine, University of California San Diego, 9500 Gilman Dr. La Jolla, CA 92093, USA.ORCID 0000-0002-1523-573X
Brian OlshanskyDepartment of Cardiology, University of Iowa, 200 Hawkins Dr, Iowa City, IA 52242, USA.ORCID 0000-0002-6044-045X
A John CammDivision of Cardiology, St George's University of London, Cranmer Terrace, London SW17 0RE, UK.ORCID 0000-0002-2536-2871
Mercy Medical Center · USSt George's, University of London · GBUniversity of California, Davis · USUniversity of California San Diego · USUniversity of Iowa · USUniversity of Maryland, Baltimore · USUniversity of Massachusetts Chan Medical School · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

aimsThe safety and feasibility of combining percutaneous catheter ablation (CA) for atrial fibrillation with left atrial appendage occlusion (LAAO) as a single procedure in the USA have not been investigated. We analyzed the US National Readmission Database (NRD) to investigate the incidence of combined LAAO + CA and compare major adverse cardiovascular events (MACEs) with matched LAAO-only and CA-only patients. METHODS AND

resultsIn this retrospective study from NRD data, we identified patients undergoing combined LAAO and CA procedures on the same day in the USA from 2016 to 2019. A 1:1 propensity score match was performed to identify patients undergoing LAAO-only and CA-only procedures. The number of LAAO + CA procedures increased from 28 (2016) to 119 (2019). LAAO + CA patients (n = 375, mean age 74 ± 9.2 years, 53.4% were males) had non-significant higher MACE (8.1%) when compared with LAAO-only (n = 407, 5.3%) or CA-only patients (n = 406, 7.4%), which was primarily driven by higher rate of pericardial effusion (4.3%). All-cause 30-day readmission rates among LAAO + CA patients (10.7%) were similar when compared with LAAO-only (12.7%) or CA-only (17.5%) patients. The most frequent primary reason for readmissions among LAAO + CA and LAAO-only cohorts was heart failure (24.6 and 31.5%, respectively), while among the CA-only cohort, it was paroxysmal atrial fibrillation (25.7%).

conclusionWe report an 63% annual growth (from 28 procedures) in combined LAAO and CA procedures in the USA. There were no significant difference in MACE and all-cause 30-day readmission rates among LAAO + CA patients compared with matched LAAO-only or CA-only patients.

Indexed as

Atrial AppendageAtrial FibrillationCatheter AblationStrokeAgedAged, 80 and overFemaleHumansMaleMiddle AgedPatient ReadmissionPropensity ScoreRetrospective StudiesTreatment OutcomeUnited StatesCA – Percutaneous Catheter-directed Atrial Fibrillation AblationLAAO – Left Atrial Appendage OcclusionMACE – Major Adverse Cardiovascular EventsNRD – National Readmission Database

Identifiers

PMID36350997
PMCPMC9935040
OpenAlexW4308688885

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.