Evidence map›Paper›PMID 36350873›Full record

ArticleJournal of applied oral science : revista FOB2022

Effects of CEACAM1 in oral keratinocytes on HO-1 expression induced by Candida β-glucan particles.

Miyuki Sakuma, Kouji Ohta, Shohei Fukada, Misaki Akagi, Hiroki Kato, Yoko Ishida, Takako Naruse, Masaaki Takechi, Hideo Shigeishi, Hiromi Nishi and 1 more

Open access · diamondAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of applied oral science : revista FOB, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.2field-weighted citation impact, top 53% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 2 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 2 institutions in 1 country.

Miyuki SakumaHiroshima University, Graduate School of Biomedical and Health Sciences, Department of Oral and Maxillofacial Surgery, Minami-Ku, Hiroshima, Japan.
Kouji OhtaHiroshima University, Graduate School of Biomedical and Health Sciences, Program of Oral Health Sciences, Department of Public Oral Health, Minami-Ku, Hiroshima, Japan.ORCID http://orcid.org/0000-0002-0603-9171
Shohei FukadaHiroshima University, Graduate School of Biomedical and Health Sciences, Department of Oral and Maxillofacial Surgery, Minami-Ku, Hiroshima, Japan.
Misaki AkagiHiroshima University, Graduate School of Biomedical and Health Sciences, Department of Oral and Maxillofacial Surgery, Minami-Ku, Hiroshima, Japan.
Hiroki KatoHiroshima University, Graduate School of Biomedical and Health Sciences, Department of Oral and Maxillofacial Surgery, Minami-Ku, Hiroshima, Japan.
Yoko IshidaHiroshima University, Graduate School of Biomedical and Health Sciences, Department of Oral and Maxillofacial Surgery, Minami-Ku, Hiroshima, Japan.
Takako NaruseHiroshima University, Graduate School of Biomedical and Health Sciences, Department of Oral and Maxillofacial Surgery, Minami-Ku, Hiroshima, Japan.
Masaaki TakechiNational Hospital Organization Kure Medical Center and Chugoku Cancer Center, Department of Dentistry, Oral and Maxillofacial Surgery, Kure, Japan.
Hideo ShigeishiHiroshima University, Graduate School of Biomedical and Health Sciences, Program of Oral Health Sciences, Department of Public Oral Health, Minami-Ku, Hiroshima, Japan.ORCID http://orcid.org/0000-0003-0883-4299
Hiromi NishiHiroshima University Hospital, Department of General Dentistry, Minami-Ku, Hiroshima, Japan.
Tomonao AikawaHiroshima University, Graduate School of Biomedical and Health Sciences, Department of Oral and Maxillofacial Surgery, Minami-Ku, Hiroshima, Japan.
Hiroshima University · JPHiroshima University of Economics · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveCarcinoembryonic antigen-related cell adhesion molecule 1 (CEACAM1) is a member of the carcinoembryonic antigen family. Although its expression has been found in chronic oral inflammatory epithelium, this study aimed to know whether CEACAM1 in oral keratinocytes participates in host immune response against Candida albicans . METHODOLOGY: We investigated CEACAM1 expression in oral keratinocytes induced by C. albicans as well as by Candida cell wall component β-glucan particles (β-GPs). Furthermore, the effects of CEACAM1 on β-GPs-induced heme oxygenase-1 (HO-1) expression and its related signals were examined.

resultsFluorescence staining showed CEACAM1 expression in oral keratinocytes (RT7) cells, whereas quantitative reverse transcription (RT)-PCR indicated that both live and heat-killed C. albicans increased CEACAM1 mRNA expression in RT7 cells. Examinations using quantitative RT-PCR and western blotting indicated that CEACAM1 expression was also increased by β-GPs derived from C. albicans . Specific siRNA for CEACAM1 decreased HO-1 expression induced by β-GPs from C. albicans as well as the budding yeast microorganism Saccharomyces cerevisiae . Moreover, knockdown of CEACAM1 decreased β-GPs-induced ROS activity in the early phase and translocation of Nrf2 into the nucleus.

conclusionCEACAM1 in oral keratinocytes may have a critical role in regulation of HO-1 for host immune defense during Candida infection.

Indexed as

beta-GlucansHeme Oxygenase-1Antigens, CDCandidaCandida albicansCarcinoembryonic AntigenCell Adhesion Molecule-1Cell Adhesion MoleculesGlucansKeratinocytesAntigens, CDbeta-GlucansCarcinoembryonic AntigenCD66 antigensCell Adhesion Molecule-1Cell Adhesion MoleculesGlucansHeme Oxygenase-1

Identifiers

PMID36350873
PMCPMC9651918
OpenAlexW4308953842

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.