ArticlePloS one2022
Neural correlates of eye contact and social function in autism spectrum disorder.
Article in PloS one, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 41 citations in OpenAlex.
- Atypical inter-brain synchrony and social communication deficits in girls with fragile X syndrome: Evidence from functional near-infrared spectroscopy hyperscanning.European child & adolescent psychiatry · 2026Article
- Listening to a Consonant Chord Progression during Live Face-to-Face Gaze Enhances Neural Activity in Social Systems.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2026Article
- The Effectiveness of an Augmented Reality-Based Early Intervention Program Using Interactive Games to Enhance Eye Contact as a Nonverbal Communication Skill in Children with Autism: A Single-Case Experimental Design.Journal of Intelligence · 2026Article
- Watching Together, Yet Feeling Apart: Interpersonal Neural Synchronization as a Marker of Symptom Severity in Children With Autism Spectrum Disorder During Naturalistic Viewing.Human brain mapping · 2026Article
- Ethno-evolutionary insights and missed critical periods hypothesis of Autism Spectrum Condition.Frontiers in child and adolescent psychiatry · 2026Article
- A developmental framework of interpersonal neural synchrony.Developmental review : DR · 2025Article
- The neural bases of language processing during social and non-social contexts: a fNIRS study of autistic and neurotypical preschool-aged children.Molecular autism · 2025Article
- Article
- Synchronization of brain activity associated with eye contact: comparison of face-to-face and online communication.Scientific reports · 2025Article
- Synchrony Across Brains.Annual review of psychology · 2025Review
- Inter-brain synchrony to delineate the social impairment in autism spectrum disorder: a systematic review on hyperscanning studies.Psychoradiology · 2025Review
- Deep multimodal representations and classification of first-episode psychosis via live face processing.Frontiers in psychiatry · 2025Article
- Mapping neural correlates of biological motion perception in autistic children using high-density diffuse optical tomography.Molecular autism · 2024Article
- The Neural Bases of Language Processing During Social and Non-Social Contexts: A fNIRS Study of Autistic and Neurotypical Preschool-Aged Children.Research square · 2024Article
- Support vector machine prediction of individual Autism Diagnostic Observation Schedule (ADOS) scores based on neural responses during live eye-to-eye contact.Scientific reports · 2024Article
- The neurosociological paradigm of the metaverse.Frontiers in psychology · 2024Article
- Neural mechanisms for emotional contagion and spontaneous mimicry of live facial expressions.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2023Article
- No evidence for differential saccadic adaptation in children and adults with an autism spectrum diagnosis.Frontiers in integrative neuroscience · 2023Article
- Separable processes for live "in-person" and live "zoom-like" faces.Imaging neuroscience (Cambridge, Mass.) · 2023Article
- Investigating face processing in online interactions via UK-US hyperscanning using fNIRS.Imaging neuroscience (Cambridge, Mass.)Article
Corrections and comments
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Authors and funding
8 authors at 2 institutions in 2 countries.
Funding
Abstract
Reluctance to make eye contact during natural interactions is a central diagnostic criterion for autism spectrum disorder (ASD). However, the underlying neural correlates for eye contacts in ASD are unknown, and diagnostic biomarkers are active areas of investigation. Here, neuroimaging, eye-tracking, and pupillometry data were acquired simultaneously using two-person functional near-infrared spectroscopy (fNIRS) during live "in-person" eye-to-eye contact and eye-gaze at a video face for typically-developed (TD) and participants with ASD to identify the neural correlates of live eye-to-eye contact in both groups. Comparisons between ASD and TD showed decreased right dorsal-parietal activity and increased right ventral temporal-parietal activity for ASD during live eye-to-eye contact (p≤0.05, FDR-corrected) and reduced cross-brain coherence consistent with atypical neural systems for live eye contact. Hypoactivity of right dorsal-parietal regions during eye contact in ASD was further associated with gold standard measures of social performance by the correlation of neural responses and individual measures of: ADOS-2, Autism Diagnostic Observation Schedule, 2nd Edition (r = -0.76, -0.92 and -0.77); and SRS-2, Social Responsiveness Scale, Second Edition (r = -0.58). The findings indicate that as categorized social ability decreases, neural responses to real eye-contact in the right dorsal parietal region also decrease consistent with a neural correlate for social characteristics in ASD.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.