ArticleJournal of feline medicine and surgery2022
Bilateral lysis of aortic saddle thrombus with early tissue plasminogen activator (BLASTT): a prospective, randomized, placebo-controlled study in feline acute aortic thromboembolism.
Article in Journal of feline medicine and surgery, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
13 citing papers in PubMed, 18 citations in OpenAlex.
- Phenotypic patterns in feline heart failure: A natural model for understanding variable disease severity in humans.iScience · 2026Article
- Multicentre aortic thromboembolism thrombolysis evaluation in a retrospective study of 183 cats: the MATTERS study.Frontiers in veterinary science · 2026Article
- Treatment and Prevention of Cardiogenic Arterial Thromboembolism in the Cat: A Systematic Review.Animals : an open access journal from MDPI · 2025Review
- Evolving FATE: A New Lens on the Pathogenesis and Management of Feline Cardiogenic Arterial Thromboembolism.Animals : an open access journal from MDPI · 2025Review
- Functional toll-like receptor 4 links endotoxin sensing to platelet priming in feline platelets.Frontiers in veterinary science · 2025Article
- Use of alteplase continuous rate infusion, pentoxifylline, and cyproheptadine in association or not, in acute feline aortic thromboembolism: a study of nine cats.Frontiers in veterinary science · 2025Article
- Surgical treatment and outcomes in feline aortic thromboembolism: a retrospective study of 13 cats.Frontiers in veterinary science · 2025Article
- Feline Aortic Thromboembolism: Recent advances and future prospects.Journal of feline medicine and surgery · 2024Review
- Utilization of peripheral glucose and lactate differences in the diagnosis of feline arterial thromboembolism: a multi-center study.Frontiers in veterinary science · 2024Article
- Case report: Evaluation of hindlimb ischemia using 18F-fluorodeoxyglucose positron emission tomography in a cat with cardiogenic arterial thromboembolism.Frontiers in veterinary science · 2023Article
- Viscoelastic coagulation monitoring parameters in cats with acute arterial thromboembolism.Journal of veterinary internal medicineArticle
- Applicability of Global Hemostatic Tools for Evaluation of Hemostatic State and Detection of Thrombosis in Cats With Cardiomyopathies.Journal of veterinary internal medicineArticle
- The effect of concurrent clopidogrel and omeprazole administration on clopidogrel metabolism and platelet function in healthy cats.Journal of veterinary internal medicineArticle
Corrections and comments
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Authors and funding
10 authors at 5 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivesThe aim of this study was to investigate the impact of tissue plasminogen activator (TPA) on the treatment of feline aortic thromboembolism (FATE).
methodsCats diagnosed with FATE involving ⩾2 limbs were enrolled in a prospective, multicenter, double-blinded, randomized, placebo-controlled study within 6 h of an event. Diagnosis was made by clinical findings and one confirmatory criterion. Cats received placebo or TPA (1 mg/kg/h with the first 10% by bolus). All cats received pain control and thromboprophylaxis. The primary outcome was a change from baseline in a published limb score at 48 h. Secondary outcomes included 48 h survival, survival to discharge and complication proportions. Statistical analyses included pattern-mixture models, logistic regression and Fisher's exact, Student's
resultsBased on a power analysis, 40 cats were enrolled; however, only 20 survived to 48 h (TPA, n = 12; placebo, n = 8 [ CONCLUSIONS AND RELEVANCE: Survival and complication rates of acute FATE were not different with or without thrombolysis. High in-hospital mortality decreased the statistical power to detect a statistically significant difference between treatments with regard to our primary outcome.
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Registered trials
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