Evidence map›Paper›PMID 36350688›Full record

ArticleMolecular biology of the cell2023

Suppression of chromosome instability by targeting a DNA helicase in budding yeast.

Molly R Gordon, Jin Zhu, Gordon Sun, Rong Li

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Molecular biology of the cell, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.4field-weighted citation impact, top 46% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 3 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 2 countries.

Molly R GordonDepartment of Cell Biology, Center for Cell Dynamics, Johns Hopkins University School of Medicine, Baltimore, MD 21205.ORCID 0000-0002-2432-5972
Jin ZhuMechanobiology Institute and.
Gordon SunDepartment of Cell Biology, Center for Cell Dynamics, Johns Hopkins University School of Medicine, Baltimore, MD 21205.
Rong LiDepartment of Cell Biology, Center for Cell Dynamics, Johns Hopkins University School of Medicine, Baltimore, MD 21205.
Johns Hopkins University · US

Funding

BIOCHEMISTRY, CELLULAR AND MOLECULAR BIOLOGY PROGRAMT32GM007445 · NIGMS · JOHNS HOPKINS UNIVERSITY · PI GREEN, RACHEL · 1985 to 2021
$24.1M
Cellular dynamics in division, motility and evolutionary adaptationR35GM118172 · NIGMS · JOHNS HOPKINS UNIVERSITY · PI LI, RONG · 2016 to 2019
$2.8M
NIGMS NIH HHS R35 GM118172NIGMS NIH HHS T32 GM007445
6 · The paper itself

Abstract

Chromosome instability (CIN) is an important driver of cancer initiation, progression, drug resistance, and aging. As such, genes whose inhibition suppresses CIN are potential therapeutic targets. We report here that deletion of an accessory DNA helicase, Rrm3, suppresses high CIN caused by a wide range of genetic or pharmacological perturbations in yeast. Although this helicase mutant has altered cell cycle dynamics, suppression of CIN by

Indexed as

DNA HelicasesSaccharomyces cerevisiae ProteinsCell Cycle ProteinsChromosomal InstabilityChromosome SegregationKinetochoresM Phase Cell Cycle CheckpointsSaccharomyces cerevisiaeCell Cycle ProteinsDNA HelicasesRrm3 protein, S cerevisiaeSaccharomyces cerevisiae Proteins

Identifiers

PMID36350688
PMCPMC9816644
OpenAlexW4308615811

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.