Evidence map›Paper›PMID 36350612›Full record

ArticleJAMA cardiology2023

Results of a Remotely Delivered Hypertension and Lipid Program in More Than 10 000 Patients Across a Diverse Health Care Network.

Alexander J Blood, Christopher P Cannon, William J Gordon, Charlotte Mailly, Taylor MacLean, Samantha Subramaniam, Michela Tucci, Jennifer Crossen, Hunter Nichols, Kavishwar B Wagholikar and 11 more

Erratum issuedAbstract read
In one paragraph

Article in JAMA cardiology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 59 papers.

0numbers the graph read from it
0cells of the map it votes in
59citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

59 citing papers in PubMed.

  1. Trial
  2. Trial
  3. Trial
  4. Home-Based Care for Hypertension in Rural South Africa.The New England journal of medicine · 2025
    Trial
  5. Trial
  6. Article
  7. Observational
  8. Article
  9. Article
  10. Article
  11. Article
  12. ANMCO position paper E-health integration in cardiology clinical care framework.European heart journal supplements : journal of the European Society of Cardiology · 2026
    Article
  13. Article
  14. Article
  15. Article
  16. Remote Blood Pressure Monitoring: A Comprehensive Review.American journal of hypertension · 2026
    Review
  17. Article
  18. Review
  19. Article
  20. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

21 authors.

Alexander J BloodDivision of Cardiovascular Medicine, Brigham and Women's Hospital, Boston, Massachusetts.
Christopher P CannonDivision of Cardiovascular Medicine, Brigham and Women's Hospital, Boston, Massachusetts.
William J GordonHarvard Medical School, Boston, Massachusetts.
Charlotte MaillyMass General Brigham Personalized Medicine, Boston, Massachusetts.
Taylor MacLeanDivision of Cardiovascular Medicine, Brigham and Women's Hospital, Boston, Massachusetts.
Samantha SubramaniamDivision of Cardiovascular Medicine, Brigham and Women's Hospital, Boston, Massachusetts.
Michela TucciDivision of Cardiovascular Medicine, Brigham and Women's Hospital, Boston, Massachusetts.
Jennifer CrossenDivision of Cardiovascular Medicine, Brigham and Women's Hospital, Boston, Massachusetts.
Hunter NicholsDivision of Cardiovascular Medicine, Brigham and Women's Hospital, Boston, Massachusetts.
Kavishwar B WagholikarLaboratory of Computer Science, Massachusetts General Hospital, Boston.
David ZelleDivision of Cardiovascular Medicine, Brigham and Women's Hospital, Boston, Massachusetts.
Marian McPartlinDivision of Cardiovascular Medicine, Brigham and Women's Hospital, Boston, Massachusetts.
Lina S MattaDepartment of Pharmacy Services, Brigham and Women's Hospital, Boston, Massachusetts.
Michael OatesMass General Brigham Personalized Medicine, Boston, Massachusetts.
Samuel AronsonMass General Brigham Personalized Medicine, Boston, Massachusetts.
Shawn MurphyHarvard Medical School, Boston, Massachusetts.
Adam LandmanHarvard Medical School, Boston, Massachusetts.
Naomi D L FisherHarvard Medical School, Boston, Massachusetts.
Thomas A GazianoDivision of Cardiovascular Medicine, Brigham and Women's Hospital, Boston, Massachusetts.
Jorge PlutzkyDivision of Cardiovascular Medicine, Brigham and Women's Hospital, Boston, Massachusetts.
Benjamin M SciricaDivision of Cardiovascular Medicine, Brigham and Women's Hospital, Boston, Massachusetts.

Funding

A framework to stratify patient cohorts for clinical managementR01HL151643 · NHLBI · MASSACHUSETTS GENERAL HOSPITAL · PI WAGHOLIKAR, KAVISHWAR B. · 2020 to 2024
$4.1M
NHLBI NIH HHS R01 HL151643
6 · The paper itself

Abstract

Importance: Blood pressure (BP) and cholesterol control remain challenging. Remote care can deliver more effective care outside of traditional clinician-patient settings but scaling and ensuring access to care among diverse populations remains elusive. Objective: To implement and evaluate a remote hypertension and cholesterol management program across a diverse health care network. Design, Setting, and Participants: Between January 2018 and July 2021, 20 454 patients in a large integrated health network were screened; 18 444 were approached, and 10 803 were enrolled in a comprehensive remote hypertension and cholesterol program (3658 patients with hypertension, 8103 patients with cholesterol, and 958 patients with both). A total of 1266 patients requested education only without medication titration. Enrolled patients received education, home BP device integration, and medication titration. Nonlicensed navigators and pharmacists, supported by cardiovascular clinicians, coordinated care using standardized algorithms, task management and automation software, and omnichannel communication. BP and laboratory test results were actively monitored. Main Outcomes and Measures: Changes in BP and low-density lipoprotein cholesterol (LDL-C). Results: The mean (SD) age among 10 803 patients was 65 (11.4) years; 6009 participants (56%) were female; 1321 (12%) identified as Black, 1190 (11%) as Hispanic, 7758 (72%) as White, and 1727 (16%) as another or multiple races (including American Indian or Alaska Native, Asian, Native Hawaiian or Other Pacific Islander, unknown, other, and declined to respond; consolidated owing to small numbers); and 142 (11%) reported a preferred language other than English. A total of 424 482 BP readings and 139 263 laboratory reports were collected. In the hypertension program, the mean (SD) office BP prior to enrollment was 150/83 (18/10) mm Hg, and the mean (SD) home BP was 145/83 (20/12) mm Hg. For those engaged in remote medication management, the mean (SD) clinic BP 6 and 12 months after enrollment decreased by 8.7/3.8 (21.4/12.4) and 9.7/5.2 (22.2/12.6) mm Hg, respectively. In the education-only cohort, BP changed by a mean (SD) -1.5/-0.7 (23.0/11.1) and by +0.2/-1.9 (30.3/11.2) mm Hg, respectively (P < .001 for between cohort difference). In the lipids program, patients in remote medication management experienced a reduction in LDL-C by a mean (SD) 35.4 (43.1) and 37.5 (43.9) mg/dL at 6 and 12 months, respectively, while the education-only cohort experienced a mean (SD) reduction in LDL-C of 9.3 (34.3) and 10.2 (35.5) mg/dL at 6 and 12 months, respectively (P < .001). Similar rates of enrollment and reductions in BP and lipids were observed across different racial, ethnic, and primary language groups. Conclusions and Relevance: The results of this study indicate that a standardized remote BP and cholesterol management program may help optimize guideline-directed therapy at scale, reduce cardiovascular risk, and minimize the need for in-person visits among diverse populations.

Indexed as

HypercholesterolemiaHypertensionAgedBlood PressureCholesterol, LDLDelivery of Health CareFemaleHumansMaleCholesterol, LDL

Identifiers

PMID36350612
PMCPMC9647559

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.