Evidence map›Paper›PMID 36350509›Full record

ArticleAdvances in experimental medicine and biology2022

Structure and Mechanism of Plant DNA Methyltransferases.

Sarah M Leichter, Jiamu Du, Xuehua Zhong

Open access · greenAbstract read
In one paragraph

Article in Advances in experimental medicine and biology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
10.3field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 22 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 2 institutions in 2 countries.

Sarah M LeichterLaboratory of Genetics, University of Wisconsin-Madison, Madison, WI, USA.
Jiamu DuKey Laboratory of Molecular Design for Plant Cell Factory of Guangdong Higher Education Institutes, Institute of Plant and Food Science, School of Life Science, Southern University of Science and Technology, Shenzhen, Guangdong, China.
Xuehua ZhongLaboratory of Genetics, University of Wisconsin-Madison, Madison, WI, USA. xuehua.zhong@wisc.edu.
Wisconsin Institutes for Discovery · USSouthern University of Science and Technology · CN

Funding

BIOTECHNOLOGY TRAINING PROGRAMT32GM008349 · NIGMS · UNIVERSITY OF WISCONSIN-MADISON · PI FOX, BRIAN G · 1989 to 2019
$22.5M
Uncovering the epigenetic codes for genome integrity, developmental and environmental interaction.R35GM124806 · NIGMS · WASHINGTON UNIVERSITY · PI XUEHUA ZHONG · 2017 to 2026
$4.2M
NIGMS NIH HHS R35 GM124806NIGMS NIH HHS T32 GM008349
6 · The paper itself

Abstract

DNA methylation is an important epigenetic mark conserved in eukaryotes from fungi to animals and plants, where it plays a crucial role in regulating gene expression and transposon silencing. Once the methylation mark is established by de novo DNA methyltransferases, specific regulatory mechanisms are required to maintain the methylation state during chromatin replication, both during meiosis and mitosis. Plant DNA methylation is found in three contexts; CG, CHG, and CHH (H = A, T, C), which are established and maintained by a unique set of DNA methyltransferases and are regulated by plant-specific pathways. DNA methylation in plants is often associated with other epigenetic modifications, such as noncoding RNA and histone modifications. This chapter focuses on the structure, function, and regulatory mechanism of plant DNA methyltransferases and their crosstalk with other epigenetic pathways.

Indexed as

ArabidopsisDNA MethylationAnimalsDNA Modification MethylasesDNA, PlantGene Expression Regulation, PlantMethyltransferasesPlantsDNA Modification MethylasesDNA, PlantMethyltransferasesChromodomainCXXC domainDRM1 DRM2MTase activityMTase domain

Identifiers

PMID36350509
PMCPMC10112988
OpenAlexW4308775186

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.