SynthesisNeurosurgical review2022
Temporal muscle thickness as an independent prognostic marker in glioblastoma patients-a systematic review and meta-analysis.
Synthesis in Neurosurgical review, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 2 of them syntheses that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
20 citing papers in PubMed, 2 syntheses or guidelines pooled it, 26 citations in OpenAlex.
- Intensity scaling of conventional brain magnetic resonance images avoiding cerebral reference regions: A systematic review.PloS one · 2024Pooled it
- Frailty and postoperative outcomes in brain tumor patients: a systematic review subdivided by tumor etiology.Journal of neuro-oncology · 2023Pooled it
- Temporalis muscle biomarkers from routine brain MRI and risk of dementia in two independent cohorts.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026Article
- Reduced Temporal Muscle Thickness Is Associated with Increased Postoperative Complications After Cranioplasty.Journal of clinical medicine · 2026Article
- Low Energy and Protein Intake in Brain Tumor Patients Despite Higher Adiposity: A Comparative Study with Gastrointestinal Cancer.Nutrients · 2026Article
- Article
- Evaluation of temporal muscle thickness in subjects with acromegaly: a follow-up study.Therapeutic advances in endocrinology and metabolism · 2026Article
- Temporal muscle measurements as predictor for outcome in a cohort of IDH-wildtype glioblastoma patients.Brain & spine · 2026Article
- Preoperative Temporal Muscle Volume as an Independent Prognostic Marker in Glioblastoma.Cureus · 2025Article
- Prognostic value of temporal muscle thickness in pediatric medulloblastoma patients aged 3-12 years.Journal of neuro-oncology · 2025Article
- Comment on "Reduced temporal muscle thickness predicts shorter survival in patients undergoing chronic subdural haematoma drainage" by Korhonen et al.-The authors' reply.Journal of cachexia, sarcopenia and muscle · 2025Article
- Temporal muscle thickness as a feasible sarcopenia marker and outcome predictor after aneurysmal subarachnoid hemorrhage.Acta neurochirurgica · 2025Article
- Temporal Muscle Thickness as a Prognostic Marker in a Real-Life Cohort of Newly Diagnosed MGMT Promoter Methylated Glioblastoma: A Multicentric Imaging Analysis.Cancer medicine · 2025Article
- Article
- Temporal and masseter muscle evaluation by MRI provides information on muscle mass and quality in acromegaly patients.Pituitary · 2024Article
- The relationship between prognosis and temporal muscle thickness in 102 patients with glioblastoma.Scientific reports · 2024Article
- Review
- Author's Reply to "Painting a Clearer Picture by Measuring the Quadriceps Muscle with Ultrasound".Gerontology · 2024Article
- Frailty in cerebellar ischemic stroke-The significance of temporal muscle thickness.Frontiers in neurology · 2023Article
- Advances in the relationship between temporal muscle thickness and prognosis of patients with glioblastoma: a narrative review.Frontiers in oncology · 2023Review
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Glioblastoma is the most common primary malignant brain tumor in the adult population. It causes the patient to incur a great deal of malady. Even with the advances in management and the Stupp protocol in place, the prognosis remains grim. There are various parameters to evaluate patients' performance status and frailty pre-operatively, but these are mostly subjective and thus suffer from inter-observer variability. Assessment of sarcopenia serves as an objective parameter to assess the patient's performance status pre-operatively. Temporalis muscle thickness serves as a surrogate to assess sarcopenia in patients with glioblastoma. We conducted a literature review and meta-analysis to determine the prognostic implications of temporalis muscle thickness in 3283 patients with primary glioblastoma. The pooled overall survival hazard's ratio of thick versus thin TMT was 0.54. The pooled progression-free survival hazard's ratio of thick versus thin TMT was 0.38. Thus, the main finding of this study is that thicker temporal muscle is associated with better OS and PFS as compared to thinner temporal muscle. We thus conclude that TMT is a viable surrogate for predicting sarcopenia and survival in primary glioblastoma. TMT measurement is extremely easy and can be incorporated as a part of the routine neurosurgical workflow in these patients. Survival prediction will help inform treatment decisions in glioblastoma patients having poor prognosis, at the initial diagnosis itself.
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Registered trials
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