Evidence map›Paper›PMID 36350483›Full record

ArticleJournal of cancer survivorship : research and practice2023

Associations between patient-reported late effects and systemic cytokines in long-term survivors of head and neck cancer treated with radiotherapy.

T T M Huynh, H C D Aass, R S Falk, G L Astrup, Å Helland, T Bjøro, K Bjordal, E Dale, T P Hellebust, B B Herlofson and 4 more

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of cancer survivorship : research and practice, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
1.6field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 10 citations in OpenAlex.

  1. Review
  2. Article
  3. Multidomain predictors of long-term work disability in late survivorship after head and neck cancer.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2026
    Article
  4. Review
  5. Review
  6. Article
  7. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 2 institutions in 1 country.

T T M HuynhFaculty of Medicine, University of Oslo, Oslo, Norway. tthyunh@uio.no.
H C D AassDepartment of Medical Biochemistry, Oslo University Hospital, Oslo, Norway.
R S FalkResearch Support Services, Oslo University Hospital, Oslo, Norway.
G L AstrupDepartment of Oncology, Oslo University Hospital, Post Box 4950, NO-0424, NydalenOslo, Norway.
Å HellandFaculty of Medicine, University of Oslo, Oslo, Norway.
T BjøroFaculty of Medicine, University of Oslo, Oslo, Norway.
K BjordalFaculty of Medicine, University of Oslo, Oslo, Norway.
E DaleDepartment of Oncology, Oslo University Hospital, Post Box 4950, NO-0424, NydalenOslo, Norway.
T P HellebustDepartment of Physics, University of Oslo, Oslo, Norway.
B B HerlofsonFaculty of Dentistry, University of Oslo, Oslo, Norway.
E MalinenDepartment of Physics, University of Oslo, Oslo, Norway.
C E KiserudDepartment of Oncology, Oslo University Hospital, Post Box 4950, NO-0424, NydalenOslo, Norway.
T OsnesFaculty of Medicine, University of Oslo, Oslo, Norway.
C D AmdalDepartment of Oncology, Oslo University Hospital, Post Box 4950, NO-0424, NydalenOslo, Norway.
Oslo University Hospital · NOUniversity of Oslo · NO

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeHead and neck cancer (HNC) treatment may lead to late effects and impaired health-related quality of life of survivors. Knowledge on long-term late effects after radiotherapy (RT) and potential underlying biological mechanisms is lacking. We assessed the prevalence of xerostomia, dysphagia, and chronic fatigue (CF) in HNC survivors ≥ 5 years post-RT, and examined associations between pro-inflammatory cytokines and late effects.

methodsIn a cross-sectional study, 263 HNC survivors treated between 2007 and 2013 were enrolled. They completed validated questionnaires assessing xerostomia and dysphagia (the EORTC QLQ-H&N35), and CF (the Fatigue Questionnaire), and underwent blood sampling and clinical examination. Pro-inflammatory cytokines were analyzed in 262 survivors and 100 healthy age- and gender-matched controls.

resultsMedian time since treatment was 8.5 years. The proportions of survivors reporting xerostomia, dysphagia, and CF were 58%, 31%, and 33%, respectively, with a preponderance of females. We found no significant associations between IL-6, IL-8, IP-10, TARC, TNF, or ENA-78 and the three late effects. The odds of having elevated levels of IL-6 and IP-10 were significantly higher in the survivors compared to the controls.

conclusionsMore than one-third of long-term HNC survivors experienced xerostomia, dysphagia, and CF. Persistent inflammation, with elevated systemic cytokines, was not associated with these late effects, although HNC survivors had higher levels of some cytokines than the controls. IMPLICATIONS FOR CANCER SURVIVORS: This study provides new knowledge on late effects that can serve as grounds for informing patients with HNC about risk of late effects more than 5 years after RT.

Indexed as

Cancer SurvivorsCytokinesDeglutition DisordersFatigue Syndrome, ChronicHead and Neck NeoplasmsXerostomiaAdultAgedCross-Sectional StudiesFemaleHumansMaleMiddle AgedPrevalenceQuality of LifeSurveys and QuestionnairesCytokinesHead and neck cancer survivorsHealth-related quality of lifeLate effectsPatient-reported outcomesPro-inflammatory cytokinesRadiotherapy

Identifiers

PMID36350483
PMCPMC9643919
OpenAlexW4308745863

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.