Evidence map›Paper›PMID 36350464›Full record

ArticleMolecular and cellular biochemistry2023

Alterations of sarcoplasmic reticulum-mediated Ca

Jaime Balderas-Villalobos, J M L Medina-Contreras, Christopher Lynch, Rajiv Kabadi, Rafael J Ramirez, Alex Y Tan, Karoly Kaszala, Montserrat Samsó, Jose F Huizar, Jose M Eltit

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Molecular and cellular biochemistry, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.8field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 6 citations in OpenAlex.

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  4. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 1 country.

Jaime Balderas-VillalobosDepartment of Physiology and Biophysics, School of Medicine, Virginia Commonwealth University, 1101 E Marshall St, 3-038H, Richmond, VA, 23298, USA.
J M L Medina-ContrerasDepartment of Physiology and Biophysics, School of Medicine, Virginia Commonwealth University, 1101 E Marshall St, 3-038H, Richmond, VA, 23298, USA.
Christopher LynchDepartment of Physiology and Biophysics, School of Medicine, Virginia Commonwealth University, 1101 E Marshall St, 3-038H, Richmond, VA, 23298, USA.
Rajiv KabadiPauley Heart Center, Virginia Commonwealth University, Richmond, VA, USA.
Rafael J RamirezDepartment of Physiology and Biophysics, School of Medicine, Virginia Commonwealth University, 1101 E Marshall St, 3-038H, Richmond, VA, 23298, USA.
Alex Y TanPauley Heart Center, Virginia Commonwealth University, Richmond, VA, USA.
Karoly KaszalaPauley Heart Center, Virginia Commonwealth University, Richmond, VA, USA.
Montserrat SamsóDepartment of Physiology and Biophysics, School of Medicine, Virginia Commonwealth University, 1101 E Marshall St, 3-038H, Richmond, VA, 23298, USA.
Jose F HuizarPauley Heart Center, Virginia Commonwealth University, Richmond, VA, USA.
Jose M EltitDepartment of Physiology and Biophysics, School of Medicine, Virginia Commonwealth University, 1101 E Marshall St, 3-038H, Richmond, VA, 23298, USA. jose.eltit@vcuhealth.org.
Virginia Commonwealth University · USHunter Holmes McGuire VA Medical Center · US

Funding

Mechanistic Insights of Premature Ventricular Contractions-induced CardiomyopathyR01HL139874 · NHLBI · VIRGINIA COMMONWEALTH UNIVERSITY · PI HUIZAR, JOSE FRANCISCO · 2018 to 2020
$2.0M
RyR architecture and gatekeeping of internal calcium storesR01AR068431 · NIAMS · VIRGINIA COMMONWEALTH UNIVERSITY · PI SAMSO, MONTSERRAT · 2017 to 2021
$2.0M
Mechanistic Insight of Premature Ventricular Contractions-induced CardiomyopathyR56HL133182 · NHLBI · VIRGINIA COMMONWEALTH UNIVERSITY · PI HUIZAR, JOSE FRANCISCO · 2016 to 2016
$507k
Neural Mechanisms of Premature Ventricular Contraction-Induced Cardiomyopathy Revealed by Targeted Neuromodulation of the Cardiac NeuraxisR01HL173183 · NHLBI · RICHMOND INSTITUTE FOR VETERANS RESEARCH · PI TAN, ALEX Y · 2025 to 2025
$473k
Validation of Swine Model for Testing a Novel Therapy for Postoperative Atrial Fibrillation using Nanoformulated Calcium Chloride to Suppress Cardiac Ganglionated PlexiI01BX004859 · VA · VA VETERANS ADMINISTRATION HOSPITAL · PI TAN, ALEX Y · 2021 to 2025
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Validation of Premature Ventricular Contraction-induced Cardiomyopathy on a Swine ModelI01BX004861 · VA · VA VETERANS ADMINISTRATION HOSPITAL · PI Jose Francisco Huizar · 2020 to 2026
–
American Heart Association-American Stroke Association 836430BLRD VA I01 BX004859BLRD VA I01 BX004861NHLBI NIH HHS R01 HL139874NHLBI NIH HHS R01 HL173183NIAMS NIH HHS R01 AR068431NIH HHS R01 AR068431NIH HHS R01 HL139874
6 · The paper itself

Abstract

Premature ventricular contractions (PVCs) are the most frequent ventricular arrhythmias in the overall population. PVCs are known to acutely enhance contractility by the post-extrasystolic potentiation phenomenon, but over time persistent PVCs promote PVC-induced cardiomyopathy (PVC-CM), characterized by a reduction of the left ventricular (LV) ejection fraction. Ca

Indexed as

CardiomyopathiesVentricular Premature ComplexesAnimalsCalciumDogsKineticsMuscle CellsMyocytes, CardiacSarcoplasmic ReticulumSarcoplasmic Reticulum Calcium-Transporting ATPasesCalciumSarcoplasmic Reticulum Calcium-Transporting ATPasesCalcium imagingCalcium reuptakeCardiac ArrhythmiaExcitation–contraction coupling

Identifiers

PMID36350464
PMCPMC10685401
OpenAlexW4308639670

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.