Evidence map›Paper›PMID 36350461›Full record

ArticleEndocrine2023

Expression of the angiogenesis markers endocan in Cushing's syndrome due to cortisol producing adenoma.

Mustafa Can, Muhammet Kocabaş, Melia Karaköse, Hacı Hasan Esen, Mustafa Kulaksızoğlu, Feridun Karakurt

Abstract read
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In one paragraph

Article in Endocrine, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact, top 85% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 0 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Mustafa CanDepartment of Internal Medicine, Division of Endocrinology and Metabolism, Muş State Hospital, Muş, Turkey. can1120can@gmail.com.ORCID 0000-0003-3241-4104
Muhammet KocabaşDepartment of Internal Medicine, Division of Endocrinology and Metabolism, Tokat State Hospital, Tokat, Turkey.
Melia KaraköseDepartment of Internal Medicine, Division of Endocrinology and Metabolism, Faculty of Medicine, Necmettin Erbakan University, Konya, Turkey.
Hacı Hasan EsenDepartment of Pathology, Faculty of Medicine, Necmettin Erbakan University, Konya, Turkey.
Mustafa KulaksızoğluDepartment of Internal Medicine, Division of Endocrinology and Metabolism, Faculty of Medicine, Necmettin Erbakan University, Konya, Turkey.
Feridun KarakurtDepartment of Internal Medicine, Division of Endocrinology and Metabolism, Faculty of Medicine, Necmettin Erbakan University, Konya, Turkey.
Necmettin Erbakan University · TRSivas State Hospital · TR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeIn this study, we aimed to investigate the endocan expression in tissue samples of patients diagnosed with Cushing's syndrome (CS) due to Cortisol-Producing-Adenoma (CPA) and compare it with normal adrenal cortex tissue, and also to evaluate the correlations of endocan expression with clinical and histopathological features.

methods11 patients who were operated for CS due to CPA between 2009-2021 and 14 control subjects with normal adrenal cortex were included in the study. Demographic, laboratory and clinicopathological data of the patients were recorded. Sections of 4-5 µm thickness were taken from paraffin blocks of patients diagnosed with CS due to CPA and control subjects with normal adrenal cortex tissue. The sections were then stained in a closed system automatic immunohistochemical staining device to perform immunohistochemical analysis. The endocan positive grade were determined based on the proportion of stained cells on a scale of negative to strong.

resultsThe number of subjects with positive endocan expression and the mean endocan expression level in the CS group were significantly higher than the control group (p = 0.005, p < 0.001, respectively). No correlation was found between endocan expression and clinical and histopathological features.

conclusionAccording to the results of our study, endocan overexpression in CPA tissues may be related to the hormonal functionality of CPA.

Indexed as

AdenomaAdrenal CortexCushing SyndromeHumansHydrocortisoneHydrocortisoneAdrenal cortexCortisol-Producing-AdenomaCushing’s syndromeEndocan

Identifiers

PMID36350461
OpenAlexW4308635026

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.