Evidence map›Paper›PMID 36350213›Full record

ArticleProceedings. Biological sciences2022

Assessing the relative importance of bacterial resistance, persistence and hyper-mutation for antibiotic treatment failure.

Christopher Witzany, Roland R Regoes, Claudia Igler

Open access · greenAbstract read
In one paragraph

Article in Proceedings. Biological sciences, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
0.7field-weighted citation impact, top 38% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 10 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Tracking the progeny of bacterial persisters using a CRISPR-based genomic recorder.Proceedings of the National Academy of Sciences of the United States of America · 2024
    Article
  5. Article
  6. Article
  7. Article
  8. Frontiers in cellular and infection microbiology · 2024
    Article
  9. Article
  10. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Christopher WitzanyInstitute of Integrative Biology, ETH Zurich, Zurich, Switzerland.ORCID 0000-0002-7128-6419
Roland R RegoesInstitute of Integrative Biology, ETH Zurich, Zurich, Switzerland.ORCID 0000-0001-8319-5293
Claudia IglerInstitute of Integrative Biology, ETH Zurich, Zurich, Switzerland.ORCID 0000-0001-7777-546X
ETH Zurich · CH

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

To curb the rising threat of antimicrobial resistance, we need to understand the routes to antimicrobial treatment failure. Bacteria can survive treatment by using both genetic and phenotypic mechanisms to diminish the effect of antimicrobials. We assemble empirical data showing that, for example,

Indexed as

Anti-Bacterial AgentsBacterial InfectionsBacteriaDrug Resistance, BacterialHumansMutationPseudomonas aeruginosaTreatment FailureAnti-Bacterial Agentsantibiotic resistance evolutionfitness calculationshyper-mutatorspersisterspharmacodynamic modellingstochastic simulations

Identifiers

PMID36350213
PMCPMC9653239
OpenAlexW4308734159

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.