Evidence map›Paper›PMID 36350114›Full record

ArticleeLife2022

Macroscopic control of cell electrophysiology through ion channel expression.

Mario García-Navarrete, Merisa Avdovic, Sara Pérez-Garcia, Diego Ruiz Sanchis, Krzysztof Wabnik

Open access · goldAbstract read
In one paragraph

Article in eLife, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.8field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 4 citations in OpenAlex.

  1. Dynamic context-dependent regulation of auxin feedback signaling in synthetic gene circuits.Proceedings of the National Academy of Sciences of the United States of America · 2023
    Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Mario García-Navarrete *Centro de Biotecnologıa y Genomica de Plantas (Universidad Politecnica de Madrid - Instituto Nacional de Investigacion y Tecnologıa Agraria y Alimentaria), Pozuelo de Alarcón, Spain.ORCID 0000-0002-1899-8206
Merisa Avdovic *Centro de Biotecnologıa y Genomica de Plantas (Universidad Politecnica de Madrid - Instituto Nacional de Investigacion y Tecnologıa Agraria y Alimentaria), Pozuelo de Alarcón, Spain.
Sara Pérez-Garcia *Centro de Biotecnologıa y Genomica de Plantas (Universidad Politecnica de Madrid - Instituto Nacional de Investigacion y Tecnologıa Agraria y Alimentaria), Pozuelo de Alarcón, Spain.
Diego Ruiz SanchisCentro de Biotecnologıa y Genomica de Plantas (Universidad Politecnica de Madrid - Instituto Nacional de Investigacion y Tecnologıa Agraria y Alimentaria), Pozuelo de Alarcón, Spain.
Krzysztof WabnikCentro de Biotecnologıa y Genomica de Plantas (Universidad Politecnica de Madrid - Instituto Nacional de Investigacion y Tecnologıa Agraria y Alimentaria), Pozuelo de Alarcón, Spain.ORCID 0000-0001-7263-0560
Instituto Nacional de Investigación y Tecnología Agraria y Alimentaria · ES

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Cells convert electrical signals into chemical outputs to facilitate the active transport of information across larger distances. This electrical-to-chemical conversion requires a tightly regulated expression of ion channels. Alterations of ion channel expression provide landmarks of numerous pathological diseases, such as cardiac arrhythmia, epilepsy, or cancer. Although the activity of ion channels can be locally regulated by external light or chemical stimulus, it remains challenging to coordinate the expression of ion channels on extended spatial-temporal scales. Here, we engineered yeast

Indexed as

Ion ChannelsPotassium ChannelsCell Physiological PhenomenaElectrophysiologySaccharomyces cerevisiaeIon ChannelsPotassium Channelsaspirinauxinbioelectricitycomputational biologyion channelsmembrane potentialphysics of living systemsS. cerevisiaesynchronizationsystems biology

Identifiers

PMID36350114
PMCPMC9711524
OpenAlexW4308608873

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.