ArticlePediatric pulmonology2023
Alveolar dead space fraction is not associated with early RV systolic dysfunction in pediatric ARDS.
Daniel Chilcote, Laura Mercer-Rosa, Yan Wang, Steven M Kawut, Robert A Berg, Nadir Yehya, Adam S Himebauch
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In one paragraphArticle in Pediatric pulmonology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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7 authors at 2 institutions in 1 country.
Daniel ChilcoteDepartment of Anesthesiology and Critical Care Medicine, Division of Critical Care Medicine, Perelman School of Medicine at the University of Pennsylvania, The Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, USA.
Laura Mercer-RosaDepartment of Pediatrics, Perelman School of Medicine at the University of Pennsylvania, The Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, USA.
Yan WangDepartment of Pediatrics, Perelman School of Medicine at the University of Pennsylvania, The Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, USA.
Steven M KawutDepartment of Medicine, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania, USA.
Robert A BergDepartment of Anesthesiology and Critical Care Medicine, Division of Critical Care Medicine, Perelman School of Medicine at the University of Pennsylvania, The Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, USA.
Nadir YehyaDepartment of Anesthesiology and Critical Care Medicine, Division of Critical Care Medicine, Perelman School of Medicine at the University of Pennsylvania, The Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, USA.
Adam S HimebauchDepartment of Anesthesiology and Critical Care Medicine, Division of Critical Care Medicine, Perelman School of Medicine at the University of Pennsylvania, The Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, USA.ORCID http://orcid.org/0000-0003-1848-2477 Children's Hospital of Philadelphia · USUniversity of Pennsylvania · US
Funding
Linking Endotypes and Outcomes in Pediatric Acute Respiratory Distress SyndromeR01HL148054 · NHLBI · CHILDREN'S HOSP OF PHILADELPHIA · PI YEHYA, NADIR · 2019 to 2023
$4.1MMentored Patient-Oriented Research in Pulmonary Arterial HypertensionK24HL103844 · NHLBI · UNIVERSITY OF PENNSYLVANIA · PI KAWUT, STEVEN M · 2011 to 2020
$1.6MValidation of Physiologic CPR Quality Using NOn-inVasive Waveform Analytics (CPR-NOVA)R01HL147616 · NHLBI · CHILDREN'S HOSP OF PHILADELPHIA · PI BERG, ROBERT ALLEN, SUTTON, ROBERT MICHAEL · 2019 to 2021
$1.2MCollaborative Pediatric Critical Care Research Network (CPCCRN)RL1HD107777 · NICHD · CHILDREN'S HOSP OF PHILADELPHIA · PI ROBERT ALLEN BERG, Julie C. Hollows Fitzgerald · 2021 to 2026
$1.1MThe Roles of Pulmonary Hypertension and Right Ventricular Dysfunction in Pediatric Acute Respiratory Distress SyndromeK23HL153759 · NHLBI · CHILDREN'S HOSP OF PHILADELPHIA · PI HIMEBAUCH, ADAM S. · 2021 to 2025
$879kNHLBI NIH HHS K23 HL153759NHLBI NIH HHS K24 HL103844NHLBI NIH HHS R01 HL147616NHLBI NIH HHS R01 HL148054NICHD NIH HHS RL1 HD107777NIH HHS 1RL1HD107777-01NIH HHS 5R01HL147616-03NIH HHS K24-HL103844
6 · The paper itselfAbstract
primary hypothesisWe hypothesized that higher alveolar dead space fraction (AVDSf) at pediatric acute respiratory distress syndrome (PARDS) onset would be associated with right ventricular (RV) systolic dysfunction within the first 24 h of PARDS. STUDY DESIGN AND
methodsWe performed a retrospective single-center cohort study of PARDS patients with clinically obtained echocardiograms within 24 h. Primary exposure was AVDSf at PARDS onset. Primary outcome was RV systolic dysfunction as defined by RV global longitudinal strain (GLS) (>-18%). Secondary outcomes included pulmonary hypertension (PH) and RV systolic dysfunction as defined by other echocardiogram parameters, and measures of oxygenation. Unadjusted and adjusted logistic and linear regression were used to investigate AVDSf associations with outcomes.
resultsNinety-one patients were included: median age 6.2 years, 46% female, and 65% with moderate or severe PARDS. Median AVDSf was 0.2 (interquartile range [IQR] 0.0-0.3), 33% had RV dysfunction, and 21% had PH. Unadjusted and adjusted logistic regression showed no association between AVDSf and RV systolic dysfunction or PH by any echocardiographic measure, but unadjusted and adjusted linear regression did show an association between AVDSf and PaO
conclusionAVDSf at PARDS onset was not associated with RV systolic dysfunction or PH within 24 h but was associated with PaO
Indexed as
Hypertension, PulmonaryRespiratory Distress SyndromeChildCohort StudiesFemaleHumansLungMaleRespirationRetrospective Studiesechocardiographyhypoxemic respiratory failurepediatricsrespiratory dead space
Identifiers
PMID36349816
PMCPMC9870940
OpenAlexW4308634749
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