Evidence map›Paper›PMID 36349758›Full record

Trial reportCirculation research2022

The Effect of a Neuronal Nitric Oxide Synthase Inhibitor on Neurovascular Regulation in Humans.

Kevin O'Gallagher, Ryan E Rosentreter, Jan Elaine Soriano, Ali Roomi, Saqib Saleem, Tyler Lam, Roman Roy, Grant R Gordon, Satish R Raj, Philip J Chowienczyk and 2 more

Open access · bronzeAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Circulation research, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
2.2field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 18 citations in OpenAlex.

  1. Review
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  10. Sex differences in gray matter, white matter, and regional brain perfusion in young, healthy adults.American journal of physiology. Heart and circulatory physiology · 2024
    Article
  11. Article
  12. Review
  13. Calcium transients in nNOS neurons underlie distinct phases of the neurovascular response to barrel cortex activation in awake mice.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2023
    Article
  14. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 4 institutions in 3 countries.

Kevin O'Gallagher *School of Cardiovascular and Metabolic Medicine & Sciences, King's College London British Heart Foundation Centre of Research Excellence, London, UK (K.O., A.R., R.R., P.J.C., A.M.S.).ORCID 0000-0003-2218-4763
Ryan E Rosentreter *Departments of Physiology and Pharmacology, Clinical Neurosciences, Cardiac Sciences, Hotchkiss Brain Institute, Libin Cardiovascular Institute of Alberta, Cumming School of Medicine, University of Calgary, Alberta, Canada (R.E.R, J.E.S., T.L., G.R.G., S.R.R., A.A.P.).
Jan Elaine SorianoDepartments of Physiology and Pharmacology, Clinical Neurosciences, Cardiac Sciences, Hotchkiss Brain Institute, Libin Cardiovascular Institute of Alberta, Cumming School of Medicine, University of Calgary, Alberta, Canada (R.E.R, J.E.S., T.L., G.R.G., S.R.R., A.A.P.).ORCID 0000-0001-5553-0808
Ali RoomiSchool of Cardiovascular and Metabolic Medicine & Sciences, King's College London British Heart Foundation Centre of Research Excellence, London, UK (K.O., A.R., R.R., P.J.C., A.M.S.).
Saqib SaleemDepartment of Electrical and Computer Engineering, COMSATS University, Sahiwal, Pakistan (S.S.).
Tyler LamDepartments of Physiology and Pharmacology, Clinical Neurosciences, Cardiac Sciences, Hotchkiss Brain Institute, Libin Cardiovascular Institute of Alberta, Cumming School of Medicine, University of Calgary, Alberta, Canada (R.E.R, J.E.S., T.L., G.R.G., S.R.R., A.A.P.).
Roman RoySchool of Cardiovascular and Metabolic Medicine & Sciences, King's College London British Heart Foundation Centre of Research Excellence, London, UK (K.O., A.R., R.R., P.J.C., A.M.S.).ORCID 0000-0002-9438-8581
Grant R GordonDepartments of Physiology and Pharmacology, Clinical Neurosciences, Cardiac Sciences, Hotchkiss Brain Institute, Libin Cardiovascular Institute of Alberta, Cumming School of Medicine, University of Calgary, Alberta, Canada (R.E.R, J.E.S., T.L., G.R.G., S.R.R., A.A.P.).
Satish R RajDepartments of Physiology and Pharmacology, Clinical Neurosciences, Cardiac Sciences, Hotchkiss Brain Institute, Libin Cardiovascular Institute of Alberta, Cumming School of Medicine, University of Calgary, Alberta, Canada (R.E.R, J.E.S., T.L., G.R.G., S.R.R., A.A.P.).ORCID 0000-0002-5890-3785
Philip J Chowienczyk *School of Cardiovascular and Metabolic Medicine & Sciences, King's College London British Heart Foundation Centre of Research Excellence, London, UK (K.O., A.R., R.R., P.J.C., A.M.S.).ORCID 0000-0003-4507-038X
Ajay M Shah *School of Cardiovascular and Metabolic Medicine & Sciences, King's College London British Heart Foundation Centre of Research Excellence, London, UK (K.O., A.R., R.R., P.J.C., A.M.S.).ORCID 0000-0002-6547-0631
Aaron A Phillips *Departments of Physiology and Pharmacology, Clinical Neurosciences, Cardiac Sciences, Hotchkiss Brain Institute, Libin Cardiovascular Institute of Alberta, Cumming School of Medicine, University of Calgary, Alberta, Canada (R.E.R, J.E.S., T.L., G.R.G., S.R.R., A.A.P.).ORCID 0000-0002-7845-1464
Libin Cardiovascular Institute of Alberta · CAGuy's and St Thomas' NHS Foundation Trust · GBBritish Heart Foundation · GBCOMSATS University Islamabad · PK

Funding

British Heart Foundation CH/1999001/11735Medical Research Council MR/R017751/1
6 · The paper itself

Abstract

backgroundNeurovascular coupling (NVC) is a key process in cerebral blood flow regulation. NVC ensures adequate brain perfusion to changes in local metabolic demands. Neuronal nitric oxide synthase (nNOS) is suspected to be involved in NVC; however, this has not been tested in humans. Our objective was to investigate the effects of nNOS inhibition on NVC in humans.

methodsWe performed a 3-visit partially randomized, double-blinded, placebo-controlled, crossover study in 12 healthy subjects. On each visit, subjects received an intravenous infusion of either S-methyl-L-thiocitrulline (a selective nNOS-inhibitor), 0.9% saline (placebo control), or phenylephrine (pressor control). The NVC assessment involved eliciting posterior circulation hyperemia through visual stimulation while measuring posterior and middle cerebral arteries blood velocity.

resultsnNOS inhibition blunted the rapidity of the NVC response versus pressor control, evidenced by a reduced initial rise in mean posterior cerebral artery velocity (-3.3% [-6.5, -0.01],

conclusionsNeuronal NOS plays a role in dynamic cerebral blood flow control in healthy adults, particularly the rapidity of the NVC response to visual stimulation. This work opens the way to further investigation of the role of nNOS in conditions of impaired NVC, potentially revealing a therapeutic target.

Indexed as

Enzyme InhibitorsNeurovascular CouplingAdultCerebrovascular CirculationCitrullineCross-Over StudiesHumansNitric OxideNitric Oxide Synthase Type IThioureaCitrullineEnzyme InhibitorsNitric OxideNitric Oxide Synthase Type IS-methylthiocitrullinethiocitrullineThioureaneurovascular couplingnitric oxide

Identifiers

PMID36349758
PMCPMC9770134
OpenAlexW4308604951

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.