Evidence map›Paper›PMID 36349721›Full record

ArticleBritish journal of haematology2023

Inherited cancer predisposing mutations in patients with therapy-related myeloid neoplasms.

Andrew J Shih, Tomi Jun, Andrew D Skol, Riyue Bao, Lei Huang, Sapana Vora, Megan E McNerney, Eric A Hungate, Michelle M Le Beau, Richard A Larson and 7 more

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in British journal of haematology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.5field-weighted citation impact, top 32% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 3 citations in OpenAlex.

  1. Review
  2. Review
  3. How I diagnose myeloid neoplasms with germline predisposition.American journal of clinical pathology · 2023
    Article
  4. Therapy-Related Myeloid Neoplasms: Predisposition and Clonal Evolution.Mediterranean journal of hematology and infectious diseases · 2023
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors at 8 institutions in 3 countries.

Andrew J ShihThe Feinstein Institute for Medical Research, Northwell Health, Manhasset, New York, USA.
Tomi JunSema4, Stamford, Connecticut, USA.ORCID 0000-0002-2120-1704
Andrew D SkolDepartment of Pediatrics, The University of Chicago, Chicago, Illinois, USA.
Riyue BaoDepartment of Medicine, The University of Pittsburgh, Pittsburgh, Pennsylvania, USA.
Lei HuangCenter for Research Informatics, The University of Chicago, Chicago, Illinois, USA.
Sapana VoraDepartment of Pediatrics, The University of Chicago, Chicago, Illinois, USA.
Megan E McNerneyDepartment of Pediatrics, The University of Chicago, Chicago, Illinois, USA.ORCID 0000-0002-8260-3598
Eric A HungateDepartment of Pediatrics, The University of Chicago, Chicago, Illinois, USA.
Michelle M Le BeauDepartment of Medicine, The University of Chicago, Chicago, Illinois, USA.
Richard A LarsonDepartment of Medicine, The University of Chicago, Chicago, Illinois, USA.
Aaron ElliottAmbry Genetics, Aliso Viejo, California, USA.
Hsiao-Mei LuAmbry Genetics, Aliso Viejo, California, USA.
Robert HuetherAmbry Genetics, Aliso Viejo, California, USA.
Felicia HernandezAmbry Genetics, Aliso Viejo, California, USA.
Friedrich StölzelDepartment of Internal Medicine I, University Hospital Carl Gustav Carus Dresden, Dresden University of Technology, Dresden, Germany.
James M AllanNorthern Institute for Cancer Research, Newcastle University, Newcastle upon Tyne, UK.
Kenan OnelSema4, Stamford, Connecticut, USA.
University of Chicago · USAmbry Genetics (United States) · USSema4 (United States) · USNewcastle University · GBNorthwell Health · USUniversity Hospital Carl Gustav Carus · DEUniversity of Illinois Chicago · USUniversity of Pittsburgh · US

Funding

VECTOR CORE FACILITYP30CA047904 · NCI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI Jessie Nedrow · 1988 to 2026
$158.0M
UCCRC--ETIOLOGY OF TREATMENT-INDUCED SECONDARY LEUKEMIAP01CA040046 · NCI · UNIVERSITY OF CHICAGO · PI LE BEAU, MICHELLE M · 1985 to 2012
$19.9M
The pathogenesis of chromosome 7q deletions in juvenile myelomonocytic leukemiaR01CA231880 · NCI · UNIVERSITY OF CHICAGO · PI MCNERNEY, MEGAN · 2018 to 2022
$1.8M
American Cancer SocietyCancer Research FoundationNCI NIH HHS P01 CA040046NCI NIH HHS P30 CA047904NCI NIH HHS R01 CA231880NIH HHS HD0433871
6 · The paper itself

Abstract

Some patients with therapy-related myeloid neoplasms (t-MN) may have unsuspected inherited cancer predisposition syndrome (CPS). We propose a set of clinical criteria to identify t-MN patients with high risk of CPS (HR-CPS). Among 225 t-MN patients with an antecedent non-myeloid malignancy, our clinical criteria identified 52 (23%) HR-CPS patients. Germline whole-exome sequencing identified pathogenic or likely pathogenic variants in 10 of 27 HR-CPS patients compared to 0 of 9 low-risk CPS patients (37% vs. 0%, p = 0.04). These simple clinical criteria identify t-MN patients most likely to benefit from genetic testing for inherited CPS.

Indexed as

NeoplasmsNeoplasms, Second PrimaryGenetic Predisposition to DiseaseGenetic TestingGerm-Line MutationHumansMutationcancer predispositiongermlineleukaemiatherapy-related myeloid neoplasmwhole-exome sequencing

Identifiers

PMID36349721
PMCPMC11246702
OpenAlexW4308637410

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.