Evidence map›Paper›PMID 36349684›Full record

SynthesisJournal of cachexia, sarcopenia and muscle2023

Consensus guidelines for sarcopenia prevention, diagnosis and management in Australia and New Zealand.

Jesse Zanker, Marc Sim, Kate Anderson, Saliu Balogun, Sharon L Brennan-Olsen, Elsa Dent, Gustavo Duque, Christian M Girgis, Mathis Grossmann, Alan Hayes and 19 more

2 registry-linked trialsOpen access · goldAbstract readSystematic Review
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Journal of cachexia, sarcopenia and muscle, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 94 papers, 11 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
94citing papers in PubMed, 11 pooled it
12.7field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06794853 recruitingnot on this mapstarted 2025, after this paper: background citation

Mechanism of Transjugular Intrahepatic Portosystemic Shunt to Improve Sarcopenia by Down-regulation of FGF21

TypeobservationalSponsorUnion Hospital, Tongji Medical College, Huazhong University of Science and TechnologyRan2025 to 2027Enrolled132ConditionsSarcopenia, Mechanism, CirrhosisArmsTransjugular Intrahepatic Portosystemic Shunt
NCT07255001 nanot yet recruitingnot on this mapstarted 2025, after this paper: background citation

Monitoring Physical Function Changes in Patients With Pancreatic Ductal Adenocarcinoma: Potential for Better Understanding of Treatment Trajectory and Survival

TypeinterventionalSponsorBritish Columbia Cancer AgencyRan2025 to 2027Enrolled50ConditionsPancreatic Ductal Adenocarcinoma (PDAC), Hand Grip StrengthArmsHand grip strength assessments using a dynamometer
3 · Its place in the literature

Who cites it

94 citing papers in PubMed, 11 syntheses or guidelines pooled it, 124 citations in OpenAlex.

  1. Pooled it
  2. Does osteosarcopenia synergistically increase risk for incident falls and fractures? A systematic review and meta-analysis.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2026
    Pooled it
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  8. Prevalence and clinical implications of sarcopenia in breast cancer: a systematic review and meta-analysis.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2024
    Pooled it
  9. Effects of exercise with or withoutFrontiers in nutrition · 2024
    Pooled it
  10. Pooled it
  11. Pooled it
  12. Cluster randomized trial of reablement strategies targeting sarcopenia (ReStart-S) in long-term care settings.The journals of gerontology. Series A, Biological sciences and medical sciences · 2026
    Trial
  13. Trial
  14. Article
  15. Repurposing niclosamide to mitigate inflammaging: a review of multi-target mechanisms in cellular senescence and age-related decline.Inflammation research : official journal of the European Histamine Research Society ... [et al.] · 2026
    Review
  16. Article
  17. Article
  18. Novel biomarkers for sarcopenia: a narrative review.Journal of orthopaedic surgery and research · 2026
    Review
  19. Article
  20. Review

34 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

29 authors at 13 institutions in 6 countries.

Jesse ZankerAustralian Institute for Musculoskeletal Science (AIMSS), The University of Melbourne and Western Health, St. Albans, Victoria, Australia.ORCID 0000-0003-3463-6827
Marc SimNutrition & Health Innovation Research Institute, School of Medical and Health Sciences, Edith Cowan University, Joondalup, Western Australia, Australia.
Kate AndersonInstitute for Health Transformation - Determinants of Health, Faculty of Health, Deakin University, Burwood, Victoria, Australia.
Saliu BalogunCollege of Health and Medicine, Australian National University, Canberra, Australian Capital Territory, Australia.
Sharon L Brennan-OlsenAustralian Institute for Musculoskeletal Science (AIMSS), The University of Melbourne and Western Health, St. Albans, Victoria, Australia.
Elsa DentTorrens University Australia, Adelaide, South Australia, Australia.
Gustavo DuqueAustralian Institute for Musculoskeletal Science (AIMSS), The University of Melbourne and Western Health, St. Albans, Victoria, Australia.
Christian M GirgisFaculty of Medicine and Health, University of Sydney, Sydney, New South Wales, Australia.
Mathis GrossmannDepartment of Medicine - Austin Health, Department of Endocrinology, The University of Melbourne, Melbourne, Victoria, Australia.
Alan HayesAustralian Institute for Musculoskeletal Science (AIMSS), The University of Melbourne and Western Health, St. Albans, Victoria, Australia.
Tim HenwoodHuman Movement and Nutritional Science, University of Queensland, Brisbane, Queensland, Australia.
Vasant HiraniNutrition and Dietetics Group, School of Life and Environmental Sciences Charles Perkins Centre, University of Sydney, New South Wales, Sydney, Australia.
Charles InderjeethNorth Metropolitan Health Service & University of Western Australia, Perth, Western Australia, Australia.
Sandra IulianoAustralian Institute for Musculoskeletal Science (AIMSS), The University of Melbourne and Western Health, St. Albans, Victoria, Australia.
Justin KeoghFaculty of Health Sciences and Medicine, Bond University, Gold Coast, Queensland, Australia.
Joshua R LewisNutrition & Health Innovation Research Institute, School of Medical and Health Sciences, Edith Cowan University, Joondalup, Western Australia, Australia.
Gordon S LynchCentre for Muscle Research, Department of Anatomy and Physiology, School of Biomedical Sciences, The University of Melbourne, Melbourne, Victoria, Australia.
Julie A PascoDepartment of Medicine - Western Health, The University of Melbourne, St. Albans, Victoria, Australia.
Steven PhuDepartment of Medicine - Western Health, The University of Melbourne, St. Albans, Victoria, Australia.
Esmee M ReijnierseDepartment of Medicine and Aged Care, @AgeMelbourne, The Royal Melbourne Hospital, The University of Melbourne, Parkville, Victoria, Australia.
Nicholas RussellDepartment of Medicine - Austin Health, Department of Endocrinology, The University of Melbourne, Melbourne, Victoria, Australia.
Lara VlietstraSchool of Physical Education, Sport and Exercise Sciences, University of Otago, Dunedin, New Zealand.
Renuka VisvanathanAdelaide Geriatrics Training and Research with Aged Care (GTRAC) Centre, School of Medicine, Faculty of Health and Medical Sciences, University of Adelaide, Adelaide, South Australia, Australia.
Troy WalkerInstitute for Health Transformation, Global Obesity Centre, Deakin University, Geelong, Victoria, Australia.
Debra L WatersSchool of Physical Education, Sport and Exercise Sciences, University of Otago, Dunedin, New Zealand.
Solomon YuAdelaide Geriatrics Training and Research with Aged Care (GTRAC) Centre, School of Medicine, Faculty of Health and Medical Sciences, University of Adelaide, Adelaide, South Australia, Australia.
Andrea B MaierDepartment of Medicine and Aged Care, @AgeMelbourne, The Royal Melbourne Hospital, The University of Melbourne, Parkville, Victoria, Australia.
Robin M DalyInstitute for Physical Activity and Nutrition, Deakin University, Burwood, Victoria, Australia.
David ScottInstitute for Physical Activity and Nutrition, Deakin University, Burwood, Victoria, Australia.
The University of Melbourne · AUDeakin University · AUEdith Cowan University · AUQueen Elizabeth Hospital · AUThe Royal Melbourne Hospital · AUThe University of Sydney · AUUniversity of Otago · NZAustralian National University · AUBarwon Health · AUBond University · AUQueensland University of Technology · AUThe University of Western Australia · AUTorrens University Australia · AU

Funding

Aarhus University HospitalAmgenAustin Hospital Medical Research FoundationAustralian Government Research Training ProgramAustralian Medical Research Future Fund APP2005987Australian National Health and Medical Research Council Investigator GNT1174886California Dairy Research FoundationCentre national interprofessionnel de l'economie laitiereDairy AustraliaDairy Council of CaliforniaDairy Farmers of CanadaDanish Dairy Research FoundationDeakin UniversityDepartment of Health and Human Services (DHHS)Dutch Dairy AssociationHospital Research FoundationMRFF APP1199726National Dairy CouncilNHMRC 2003179NHMRC APP1099173NHMRC APP1162867NHMRC CRE 1102208Norman Beischer Foundationonterra Co-operative Group LtdRoyal Perth Hospital Career Advancement Fellowship CAF 130/2020Sir Edward Dunlop Medical Research FoundationUniversity of MelbourneWellcome Trust 102817Western Australian Future Health and Innovation Fund
6 · The paper itself

Abstract

backgroundSarcopenia is an age-associated skeletal muscle condition characterized by low muscle mass, strength, and physical performance. There is no international consensus on a sarcopenia definition and no contemporaneous clinical and research guidelines specific to Australia and New Zealand. The Australian and New Zealand Society for Sarcopenia and Frailty Research (ANZSSFR) Sarcopenia Diagnosis and Management Task Force aimed to develop consensus guidelines for sarcopenia prevention, assessment, management and research, informed by evidence, consumer opinion, and expert consensus, for use by health professionals and researchers in Australia and New Zealand.

methodsA four-phase modified Delphi process involving topic experts and informed by consumers, was undertaken between July 2020 and August 2021. Phase 1 involved a structured meeting of 29 Task Force members and a systematic literature search from which the Phase 2 online survey was developed (Qualtrics). Topic experts responded to 18 statements, using 11-point Likert scales with agreement threshold set a priori at >80%, and five multiple-choice questions. Statements with moderate agreement (70%-80%) were revised and re-introduced in Phase 3, and statements with low agreement (<70%) were rejected. In Phase 3, topic experts responded to six revised statements and three additional questions, incorporating results from a parallel Consumer Expert Delphi study. Phase 4 involved finalization of consensus statements.

resultsTopic experts from Australia (n = 62, 92.5%) and New Zealand (n = 5, 7.5%) with a mean ± SD age of 45.7 ± 11.8 years participated in Phase 2; 38 (56.7%) were women, 38 (56.7%) were health professionals and 27 (40.3%) were researchers/academics. In Phase 2, 15 of 18 (83.3%) statements on sarcopenia prevention, screening, assessment, management and future research were accepted with strong agreement. The strongest agreement related to encouraging a healthy lifestyle (100%) and offering tailored resistance training to people with sarcopenia (92.5%). Forty-seven experts participated in Phase 3; 5/6 (83.3%) revised statements on prevention, assessment and management were accepted with strong agreement. A majority of experts (87.9%) preferred the revised European Working Group for Sarcopenia in Older Persons (EWGSOP2) definition. Seventeen statements with strong agreement (>80%) were confirmed by the Task Force in Phase 4.

conclusionsThe ANZSSFR Task Force present 17 sarcopenia management and research recommendations for use by health professionals and researchers which includes the recommendation to adopt the EWGSOP2 sarcopenia definition in Australia and New Zealand. This rigorous Delphi process that combined evidence, consumer expert opinion and topic expert consensus can inform similar initiatives in countries/regions lacking consensus on sarcopenia.

Indexed as

Resistance TrainingSarcopeniaAdultAgedAustraliaConsensusFemaleHumansMaleMiddle AgedNew ZealandAgedGeriatric assessmentMass screeningSarcopenia

Identifiers

PMID36349684
PMCPMC9891980
OpenAlexW4308603598

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.