Evidence map›Paper›PMID 36349598›Full record

ArticleNeuroImage2022

Ventral tegmental area integrity measured with high-resolution 7-Tesla MRI relates to motivation across depression and anxiety diagnoses.

Laurel S Morris, Marishka Mehta, Christopher Ahn, Morgan Corniquel, Gaurav Verma, Bradley Delman, Patrick R Hof, Yael Jacob, Priti Balchandani, James W Murrough

Open access · goldAbstract read
In one paragraph

Article in NeuroImage, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
1.6field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 15 citations in OpenAlex.

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  11. Neuromelanin-sensitive MRI for mechanistic research and biomarker development in psychiatry.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2024
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 1 country.

Laurel S MorrisDepartment of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, USA; BioMedical Engineering and Imaging Institute, Icahn School of Medicine at Mount Sinai, New York, USA. Electronic address: laurel.morris@mssm.edu.
Marishka MehtaDepartment of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, USA.
Christopher AhnDepartment of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, USA.
Morgan CorniquelDepartment of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, USA.
Gaurav VermaBioMedical Engineering and Imaging Institute, Icahn School of Medicine at Mount Sinai, New York, USA; Department of Radiology, Icahn School of Medicine at Mount Sinai, New York, USA.
Bradley DelmanBioMedical Engineering and Imaging Institute, Icahn School of Medicine at Mount Sinai, New York, USA; Department of Radiology, Icahn School of Medicine at Mount Sinai, New York, USA.
Patrick R HofNash Family Department of Neuroscience and Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, USA.
Yael JacobDepartment of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, USA; BioMedical Engineering and Imaging Institute, Icahn School of Medicine at Mount Sinai, New York, USA; Department of Radiology, Icahn School of Medicine at Mount Sinai, New York, USA.
Priti BalchandaniBioMedical Engineering and Imaging Institute, Icahn School of Medicine at Mount Sinai, New York, USA; Department of Radiology, Icahn School of Medicine at Mount Sinai, New York, USA.
James W MurroughDepartment of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, USA; Nash Family Department of Neuroscience and Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, USA.
Icahn School of Medicine at Mount Sinai · USAllen Institute for Brain Science · US

Funding

Transdiagnostic Multimodal 7 Tesla MRI of the Locus Coeruleus in Human Pathological AnxietyR01MH116953 · NIMH · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI BALCHANDANI, PRITI, MURROUGH, JAMES WARREN · 2019 to 2023
$3.0M
7T MRI to reveal structural, connectomic and metabolic imaging markers for the neurobiology of depressionR01MH109544 · NIMH · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI BALCHANDANI, PRITI · 2016 to 2020
$2.1M
Characterizing constructs of motivation and the midbrain dopaminergic system in depression with ultra-high field MRIK01MH120433 · NIMH · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI MORRIS, LAUREL SOPHIA · 2019 to 2022
$563k
NIMH NIH HHS K01 MH120433NIMH NIH HHS R01 MH109544NIMH NIH HHS R01 MH116953
6 · The paper itself

Abstract

The ventral tegmental area (VTA) is one of the major sources of dopamine in the brain and has been associated with reward prediction, error-based reward learning, volitional drive and anhedonia. However, precise anatomical investigations of the VTA have been prevented by the use of standard-resolution MRI, reliance on subjective manual tracings, and lack of quantitative measures of dopamine-related signal. Here, we combine ultra-high field 400 µm

Indexed as

DopamineVentral Tegmental AreaAnxietyAnxiety DisordersHumansMotivationRewardDopamine

Identifiers

PMID36349598
PMCPMC9801251
OpenAlexW4308346205

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.