ArticleEuropace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology2023
Atrial fibrillation onset before heart failure or vice versa: what is worst? A nationwide register study.
Article in Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed.
- Integrated proteomics and machine learning reveal AHNAK as a discriminative biomarker of atrial fibrillation in heart failure.BMC medicine · 2026Article
- Development of atrial fibrillation in patients with heart failure and vice versa: incidence, risk factors, and their impact on survival.ESC heart failure · 2026Article
- Stratifying prognosis in heart failure patients with reduced ejection fraction and atrial cardiomyopathy.ESC heart failure · 2026Article
- Atrial fibrillation and metabolic syndrome: an updated review of mechanisms, risk factors, and therapeutic strategies.Frontiers in cardiovascular medicine · 2026Review
- Integrating systemic inflammation and liver biomarkers: prognostic implications of the ferritin index in heart failure.Annals of medicine · 2025Article
- Optic neuritis and risk of heart failure and atrial fibrillation: A nationwide cohort study.PNAS nexus · 2025Article
- Identification, characterisation and outcomes of pre-atrial fibrillation in heart failure with reduced ejection fraction.ESC heart failure · 2025Article
- Incidence of atrial fibrillation in patients with an insertable cardiac monitor and symptomatic heart failure.ESC heart failure · 2025Article
- Clonal Hematopoiesis of Indeterminate Potential and Atrial Fibrillation: Insights into Pathophysiology and Clinical Implications.International journal of molecular sciences · 2025Review
- A Multidirectional Interrelationship: Iron Deficiency Anemia Begets Angular Cheilitis and Atrial Fibrillation, Atrial Fibrillation Begets Heart Failure and Heart Failure Begets Atrial Fibrillation and AnemiaBalkan medical journal · 2025Article
- L-shaped association of plasma low-density lipoprotein cholesterol with atrial fibrillation recurrence after catheter ablation: a prospective cohort study.Scientific reports · 2024Article
- Sex differences in atrial fibrillation ablation outcomes in patients with heart failure.Journal of interventional cardiac electrophysiology : an international journal of arrhythmias and pacing · 2024Article
- All-Cause Mortality of Atrial Fibrillation and Heart Failure in the Same Patient: Does the Order Matter?Cardiology and therapy · 2024Article
- Global burden of atrial fibrillation/atrial flutter and its attributable risk factors from 1990 to 2021.Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology · 2024Article
- Heart Failure-Related Death in Subjects With Atrial Fibrillation in the United States, 1999 to 2020.Journal of the American Heart Association · 2024Article
- Catheter ablation in patients with atrial fibrillation and dilated cardiomyopathy.Frontiers in cardiovascular medicine · 2024Article
- Benefit of Catheter Ablation for Atrial Fibrillation in Heart Failure Patients with Different Etiologies.Journal of cardiovascular development and disease · 2023Article
- Risk of myocardial infarction and ischemic stroke in individuals with first-diagnosed paroxysmal vs. non-paroxysmal atrial fibrillation under anticoagulation.Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology · 2023Article
- Catheter ablation improved ejection fraction in persistent AF patients: a DECAAF-II sub analysis.Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology · 2023Article
- Atrial fibrillation and heart failure temporality: does it matter?Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology · 2023Article
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10 authors.
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No grant is acknowledged in the PubMed record.
Abstract
aimsAtrial fibrillation (AF) and heart failure (HF) often coexist. However, whether AF onset before HF or vice versa is associated with the worst outcome remains unclear. A consensus of large studies can guide future research and preventive strategies to better target high-risk patients. METHODS AND
resultsWe included all Danish cases with the coexistence of AF and HF (2005-17) using nationwide registries. Patients were divided into three separate groups (i) AF before HF, (ii) HF before AF, or (iii) AF and HF diagnosed concurrently (±30 days). Adjusting landmark Cox analyses (index date was the time of the latter diagnosis of AF or HF) were used for evaluating the association of the three groups with a composite outcome of ischaemic stroke or death. Among a total of 49 042 patients included, 40% had AF before HF, 27% had HF before AF, and 33% had AF and HF diagnosed concurrently. The composite endpoint accrued more often in patients with HF before AF compared to the two other groups (<0.001), and this remained significant in the adjusted analyses with hazard ratios (95% confidence intervals) of 1.26 (1.22-1.30) compared to AF before HF. Finally, antihypertensive treatment, oral anticoagulants, amiodarone, statins, and AF ablation were associated with a lower hazard ratio of the composite endpoint (all < 0.001).
conclusionsIn this large Danish national cohort, diagnosis of HF before AF was associated with an increased absolute risk of death compared to AF before HF and AF and HF diagnosed concurrently. Antihypertensive treatment, oral anticoagulants, amiodarone, statins, and AF ablation may improve prognosis.
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