Evidence map›Paper›PMID 36349548›Full record

ArticleLab on a chip2022

A microfluidic fully paper-based analytical device integrated with loop-mediated isothermal amplification and nano-biosensors for rapid, sensitive, and specific quantitative detection of infectious diseases.

Hamed Tavakoli, Elisabeth Hirth, Man Luo, Sanjay Sharma Timilsina, Maowei Dou, Delfina C Dominguez, XiuJun Li

Open access · greenAbstract read
In one paragraph

Article in Lab on a chip, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
2.1field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 26 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 2 countries.

Hamed TavakoliDepartment of Chemistry and Biochemistry, University of Texas at El Paso, El Paso, Texas, 79968, USA. xli4@utep.edu.
Elisabeth HirthDepartment of Chemistry and Biochemistry, University of Texas at El Paso, El Paso, Texas, 79968, USA. xli4@utep.edu.
Man LuoDepartment of Chemistry and Biochemistry, University of Texas at El Paso, El Paso, Texas, 79968, USA. xli4@utep.edu.
Sanjay Sharma TimilsinaDepartment of Chemistry and Biochemistry, University of Texas at El Paso, El Paso, Texas, 79968, USA. xli4@utep.edu.
Maowei DouDepartment of Chemistry and Biochemistry, University of Texas at El Paso, El Paso, Texas, 79968, USA. xli4@utep.edu.
Delfina C DominguezCollege of Health Sciences, University of Texas at El Paso, El Paso, TX, USA.
XiuJun LiDepartment of Chemistry and Biochemistry, University of Texas at El Paso, El Paso, Texas, 79968, USA. xli4@utep.edu.ORCID 0000-0002-7954-0717
The University of Texas at El Paso · US

Funding

Technologies and Resources CoreU54MD007593 · NIMHD · MEHARRY MEDICAL COLLEGE · PI ADUNYAH, SAMUEL EVANS · 2012 to 2018
$24.7M
Grafting DNA Codes on Paper for Rapid, Low-Cost, and Sensitive Meningitis DiagnosSC2GM105584 · NIGMS · UNIVERSITY OF TEXAS EL PASO · PI LI, XIUJUN · 2013 to 2015
$438k
Design of Point of Care Device for the Rapid Diagnosis of PertussisR21AI107415 · NIAID · UNIVERSITY OF TEXAS EL PASO · PI DOMINGUEZ, DELFINA C, LI, XIUJUN · 2015 to 2016
$405k
Point-of-care microdevices for simultaneous detection of multiple pertussis-like respiratory diseases from Bordetella speciesR41AI162477 · NIAID · MICROBIOCHIP DIAGNOSTICS LLC · PI LI, XIUJUN · 2022 to 2023
$391k
NIAID NIH HHS R21 AI107415NIAID NIH HHS R41 AI162477NIGMS NIH HHS SC2 GM105584NIMHD NIH HHS U54 MD007593
6 · The paper itself

Abstract

Bacterial meningitis, an infection of the membranes (meninges) and cerebrospinal fluid (CSF) surrounding the brain and spinal cord, is one of the major causes of death and disability worldwide. Higher case-fatality rates and short survival times have been reported in developing countries. Hence, a quick, straightforward, and low-cost approach is in great demand for the diagnosis of meningitis. In this research, a microfluidic fully paper-based analytical device (μFPAD) integrated with loop-mediated isothermal amplification (LAMP) and ssDNA-functionalized graphene oxide (GO) nano-biosensors was developed for the first time for a simple, rapid, low-cost, and quantitative detection of the main meningitis-causing bacteria,

Indexed as

Communicable DiseasesNeisseria meningitidisHumansLab-On-A-Chip DevicesMicrofluidicsMolecular Diagnostic TechniquesNucleic Acid Amplification Techniques

Identifiers

PMID36349548
PMCPMC9701502
OpenAlexW4308638597

What OpenQuestion holds

Textmetadata
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.