Evidence map›Paper›PMID 36349444›Full record

ArticleJournal of the Royal Society, Interface2022

Directional control of neurite outgrowth: emerging technologies for Parkinson's disease using magnetic nanoparticles and magnetic field gradients.

K Dhillon, K Aizel, T J Broomhall, E Secret, T Goodman, M Rotherham, N Telling, J M Siaugue, C Ménager, J Fresnais and 3 more

Open access · hybridAbstract read
In one paragraph

Article in Journal of the Royal Society, Interface, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
1.3field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 16 citations in OpenAlex.

  1. Article
  2. Review
  3. Review
  4. Review
  5. Mechanical Forces Guide Axon Growth through the Nigrostriatal Pathway in an Organotypic Model.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025
    Article
  6. Article
  7. Article
  8. Review
  9. Surface Tension and Neuronal Sorting in Magnetically Engineered Brain-Like Tissue.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2023
    Article
  10. Article
  11. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 3 institutions in 2 countries.

K DhillonHealthcare Technologies Institute, Department of Chemical Engineering, University of Birmingham, Birmingham, UK.ORCID 0000-0003-1335-8442
K AizelInstitut Curie, PSL Research University, CNRS, Sorbonne Université, Physico Chimie, Paris, France.
T J BroomhallHealthcare Technologies Institute, Department of Chemical Engineering, University of Birmingham, Birmingham, UK.ORCID 0000-0002-7528-0831
E SecretSorbonne Université, CNRS, Laboratoire Physicochimie des Électrolytes et Nanosystèmes Interfaciaux, PHENIX, 75005 Paris, France.ORCID 0000-0003-2200-7265
T GoodmanSchool of Pharmacy and Bioengineering, Guy Hilton Research Centre, Keele University, Staffordshire, UK.
M RotherhamHealthcare Technologies Institute, Department of Chemical Engineering, University of Birmingham, Birmingham, UK.ORCID 0000-0002-9297-7681
N TellingSchool of Pharmacy and Bioengineering, Guy Hilton Research Centre, Keele University, Staffordshire, UK.ORCID 0000-0002-2683-5546
J M SiaugueSorbonne Université, CNRS, Laboratoire Physicochimie des Électrolytes et Nanosystèmes Interfaciaux, PHENIX, 75005 Paris, France.ORCID 0000-0003-1217-9493
C MénagerSorbonne Université, CNRS, Laboratoire Physicochimie des Électrolytes et Nanosystèmes Interfaciaux, PHENIX, 75005 Paris, France.ORCID 0000-0002-4080-3508
J FresnaisSorbonne Université, CNRS, Laboratoire Physicochimie des Électrolytes et Nanosystèmes Interfaciaux, PHENIX, 75005 Paris, France.ORCID 0000-0002-2037-0637
M CoppeyInstitut Curie, PSL Research University, CNRS, Sorbonne Université, Physico Chimie, Paris, France.ORCID 0000-0001-8924-3233
A J El HajHealthcare Technologies Institute, Department of Chemical Engineering, University of Birmingham, Birmingham, UK.ORCID 0000-0003-3544-5678
M A GatesSchool of Pharmacy and Bioengineering, Guy Hilton Research Centre, Keele University, Staffordshire, UK.ORCID 0000-0002-2901-1083
Centre National de la Recherche Scientifique · FRUniversity of Birmingham · GBKeele University · GB

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

A challenge in current stem cell therapies for Parkinson's disease (PD) is controlling neuronal outgrowth from the substantia nigra towards the targeted area where connectivity is required in the striatum. Here we present progress towards controlling directional neurite extensions through the application of iron-oxide magnetic nanoparticles (MNPs) labelled neuronal cells combined with a magnetic array generating large spatially variant field gradients (greater than 20 T m

Indexed as

Magnetite NanoparticlesParkinson DiseaseAnimalsMagnetic FieldsNeuritesNeuronal OutgrowthRatsMagnetite Nanoparticlesmagnetic nanoparticlesneurite outgrowthregenerative medicinetissue engineering

Identifiers

PMID36349444
PMCPMC9653228
OpenAlexW4308688340

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.