Evidence map›Paper›PMID 36349119›Full record

ArticleBrain communications2022

Neurons derived from individual early Alzheimer's disease patients reflect their clinical vulnerability.

Bryan Ng, Helen A Rowland, Tina Wei, Kanisa Arunasalam, Emma Mee Hayes, Ivan Koychev, Anne Hedegaard, Elena M Ribe, Dennis Chan, Tharani Chessell and 13 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Brain communications, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed.

  1. Article
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  12. CRISPRi: a way to integrate iPSC-derived neuronal models.Biochemical Society transactions · 2024
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

23 authors.

Bryan NgDepartment of Physiology Anatomy and Genetics, University of Oxford, South Parks Road, Oxford OX1 3QU, UK.ORCID https://orcid.org/0000-0002-6819-0176
Helen A RowlandKavli Institute for Nanoscience Discovery, University of Oxford, Dorothy Crowfoot Hodgkin Building, South Parks Road, Oxford OX1 3QU, UK.
Tina WeiKavli Institute for Nanoscience Discovery, University of Oxford, Dorothy Crowfoot Hodgkin Building, South Parks Road, Oxford OX1 3QU, UK.
Kanisa ArunasalamNuffield Department of Clinical Neurosciences, University of Oxford, Dorothy Crowfoot Hodgkin Building, South Parks Road, Oxford OX1 3QU, UK.
Emma Mee HayesNuffield Department of Clinical Neurosciences, University of Oxford, Dorothy Crowfoot Hodgkin Building, South Parks Road, Oxford OX1 3QU, UK.
Ivan KoychevDepartment of Psychiatry, University of Oxford, Headington, Oxford OX3 7JX, UK.
Anne HedegaardDepartment of Psychiatry, University of Oxford, Headington, Oxford OX3 7JX, UK.
Elena M RibeDepartment of Psychiatry, University of Oxford, Headington, Oxford OX3 7JX, UK.
Dennis ChanDepartment of Clinical Neurosciences, University of Cambridge, Cambridge CB2 0QQ, UK.
Tharani ChessellNeuroscience, Innovative Medicines and Early Development, AstraZeneca AKB, Granta Park, Cambridge, CB21 6GH, UK.
Dominic FfytcheDepartment of Old Age Psychiatry, Institute of Psychiatry, Psychology and Neuroscience, Kings College London, London, SE5 8AF, UK.
Roger N GunnInvicro & Department of Brain Sciences, Burlington Danes Building, Imperial College London, Hammersmith Hospital, Du Cane Road, London, W12 0NN, UK.
Ece KocagoncuMedical Research Council Cognition and Brain Sciences Unit, Department of Clinical Neurosciences and Cambridge University Hospitals NHS Trust, University of Cambridge, Cambridge CB2 7EF, UK.ORCID https://orcid.org/0000-0002-6292-7472
Jennifer LawsonDepartment of Psychiatry, University of Oxford, Headington, Oxford OX3 7JX, UK.
Paresh A MalhotraDepartment of Brain Sciences, Imperial College London, Charing Cross Campus, London W6 8RP, UK.ORCID https://orcid.org/0000-0002-1897-0780
Basil H RidhaDementia Research Centre, UCL Institute of Neurology, Queen Square, London, WC1N 3BG, UK.ORCID https://orcid.org/0000-0002-8850-9922
James B RoweMedical Research Council Cognition and Brain Sciences Unit, Department of Clinical Neurosciences and Cambridge University Hospitals NHS Trust, University of Cambridge, Cambridge CB2 7EF, UK.
Alan J ThomasTranslational and Clinical Research Institute, Newcastle University, Newcastle, UK.
Giovanna ZamboniNuffield Department of Clinical Neurosciences, Headington, University of Oxford, Oxford OX3 9DS, UK.ORCID https://orcid.org/0000-0002-6133-3373
Noel J BuckleyKavli Institute for Nanoscience Discovery, University of Oxford, Dorothy Crowfoot Hodgkin Building, South Parks Road, Oxford OX1 3QU, UK.
Zameel M CaderKavli Institute for Nanoscience Discovery, University of Oxford, Dorothy Crowfoot Hodgkin Building, South Parks Road, Oxford OX1 3QU, UK.ORCID https://orcid.org/0000-0002-6952-406X
Simon LovestoneDepartment of Psychiatry, University of Oxford, Headington, Oxford OX3 7JX, UK.
Richard Wade-MartinsDepartment of Physiology Anatomy and Genetics, University of Oxford, South Parks Road, Oxford OX1 3QU, UK.

Funding

Medical Research Council MC_EX_MR/N50192X/1Medical Research Council MC_U105597119Medical Research Council MC_UU_00005/12Medical Research Council MR/L023784/2Medical Research Council MR/M024962/1Medical Research Council MR/N029453/1Medical Research Council MR/N029941/1Medical Research Council MR/P007058/1Medical Research Council MR/T033371/1Parkinson's UK G-0801Parkinson's UK G-1003Parkinson's UK H-1102Parkinson's UK H-1301Parkinson's UK J-0901Parkinson's UK K-1003
6 · The paper itself

Abstract

Establishing preclinical models of Alzheimer's disease that predict clinical outcomes remains a critically important, yet to date not fully realized, goal. Models derived from human cells offer considerable advantages over non-human models, including the potential to reflect some of the inter-individual differences that are apparent in patients. Here we report an approach using induced pluripotent stem cell-derived cortical neurons from people with early symptomatic Alzheimer's disease where we sought a match between individual disease characteristics in the cells with analogous characteristics in the people from whom they were derived. We show that the response to amyloid-β burden

Indexed as

Alzheimer’s diseaseclinical vulnerabilitydisease modellinginduced pluripotent stem cellssynapse loss

Identifiers

PMID36349119
PMCPMC9636855

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.