Evidence map›Paper›PMID 36349054›Full record

ArticleInternational journal of clinical practice2022

Association of Interleukin-17F Polymorphism and Mortality Predictors with the Risk of COVID-19.

Manal M El-Desoky, Samar Tharwat, Nora Mostafa, Asem A Hewidy, Rehab A Elmorsey, Mona S Abdelhafez, Amira H El-Ashry, Mona M Elhendawi, Aya Ahmed Fathy, Fatma Azzahraa Hisham

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In one paragraph

Article in International journal of clinical practice, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.5field-weighted citation impact, top 35% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 5 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 1 institution in 1 country.

Manal M El-DesokyMedical Biochemistry and Molecular Biology Department, Faculty of Medicine, Mansoura University, Mansoura, Egypt.
Samar TharwatRheumatology & Immunology Unit, Department of Internal Medicine, Faculty of Medicine, Mansoura University, Mansoura, Egypt.ORCID https://orcid.org/0000-0001-9892-2449
Nora MostafaMedical Biochemistry and Molecular Biology Department, Faculty of Medicine, Mansoura University, Mansoura, Egypt.
Asem A HewidyChest Medicine Department, Faculty of Medicine, Mansoura University, Mansoura, Egypt.
Rehab A ElmorseyChest Medicine Department, Faculty of Medicine, Mansoura University, Mansoura, Egypt.
Mona S AbdelhafezMedical Microbiology and Immunology Department, Faculty of Medicine, Mansoura University, Mansoura, Egypt.
Amira H El-AshryMedical Microbiology and Immunology Department, Faculty of Medicine, Mansoura University, Mansoura, Egypt.
Mona M ElhendawiClinical Pathology Department, Faculty of Medicine, Mansoura University, Mansoura, Egypt.
Aya Ahmed FathyPublic Health and Community Medicine, Faculty of Medicine, Mansoura University, Mansoura, Egypt.
Fatma Azzahraa HishamMedical Biochemistry and Molecular Biology Department, Faculty of Medicine, Mansoura University, Mansoura, Egypt.
Mansoura University · EG

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Th-17 cells, a proinflammatory subset of CD4 T lymphocytes, have been suggested as a possible cause of coronavirus disease-19 (COVID-19)-related immunological injuries. The aim of this study was to investigate the relationship between IL-17F (rs763780) polymorphism and the susceptibility to and outcomes of COVID-19 infection and to determine the clinical and laboratory predictors of COVID-19 death. Methods: This case-control study included 132 COVID-19 patients and 135 healthy age- and sex-matched controls. The participants were tested for IL-17F rs763780 polymorphism via TaqMan-based genotyping and for the expression of IL-17 by enzyme-linked immunosorbent assay. This study also investigated the predictors for COVID-19 mortality. Results: A non-statistically significant association was observed between IL-17F alleles and genotypes with COVID-19 ( Conclusion: The findings indicate that the IL-17F H161R variant does not influence the risk of COVID-19. However, the IL-17 level is a perfect discriminator of COVID-19 infection. Hypertension, age of >57 years, white blood cell count of >12.6 × 10

Indexed as

COVID-19HypertensionCase-Control StudiesGenetic Predisposition to DiseaseGenotypeHumansInterleukin-17Middle AgedPolymorphism, Single NucleotideInterleukin-17

Identifiers

PMID36349054
PMCPMC9633175
OpenAlexW4307423214

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.