Precisely controlling the cellular internalization of DNA-decorated semiconductor polymer nanoparticles for drug delivery.

Ying Tan, Mengyi Xiong, Qin Liu, Yao Yin, Xia Yin, Shiyi Liao, Youjuan Wang, Ling Hu, Xiao-Bing Zhang

Abstract read

In one paragraph

Article in RSC advances, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it

0cells of the map it votes in

0citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Ying TanMolecular Science and Biomedicine Laboratory, State Key Laboratory of Chemo/Biosensing and Chemometrics, College of Chemistry and Chemical Engineering, Collaborative Innovation Center for Chemistry and Molecular Medicine, Hunan University Changsha 41008 P. R. China xbzhang@hnu.edu.cn yinxia@hnu.edu.cn xiongmy@hnu.edu.cn.

Mengyi XiongMolecular Science and Biomedicine Laboratory, State Key Laboratory of Chemo/Biosensing and Chemometrics, College of Chemistry and Chemical Engineering, Collaborative Innovation Center for Chemistry and Molecular Medicine, Hunan University Changsha 41008 P. R. China xbzhang@hnu.edu.cn yinxia@hnu.edu.cn xiongmy@hnu.edu.cn.

Qin LiuMolecular Science and Biomedicine Laboratory, State Key Laboratory of Chemo/Biosensing and Chemometrics, College of Chemistry and Chemical Engineering, Collaborative Innovation Center for Chemistry and Molecular Medicine, Hunan University Changsha 41008 P. R. China xbzhang@hnu.edu.cn yinxia@hnu.edu.cn xiongmy@hnu.edu.cn.

Yao YinMolecular Science and Biomedicine Laboratory, State Key Laboratory of Chemo/Biosensing and Chemometrics, College of Chemistry and Chemical Engineering, Collaborative Innovation Center for Chemistry and Molecular Medicine, Hunan University Changsha 41008 P. R. China xbzhang@hnu.edu.cn yinxia@hnu.edu.cn xiongmy@hnu.edu.cn.

Xia YinMolecular Science and Biomedicine Laboratory, State Key Laboratory of Chemo/Biosensing and Chemometrics, College of Chemistry and Chemical Engineering, Collaborative Innovation Center for Chemistry and Molecular Medicine, Hunan University Changsha 41008 P. R. China xbzhang@hnu.edu.cn yinxia@hnu.edu.cn xiongmy@hnu.edu.cn.

Shiyi LiaoMolecular Science and Biomedicine Laboratory, State Key Laboratory of Chemo/Biosensing and Chemometrics, College of Chemistry and Chemical Engineering, Collaborative Innovation Center for Chemistry and Molecular Medicine, Hunan University Changsha 41008 P. R. China xbzhang@hnu.edu.cn yinxia@hnu.edu.cn xiongmy@hnu.edu.cn.

Youjuan WangMolecular Science and Biomedicine Laboratory, State Key Laboratory of Chemo/Biosensing and Chemometrics, College of Chemistry and Chemical Engineering, Collaborative Innovation Center for Chemistry and Molecular Medicine, Hunan University Changsha 41008 P. R. China xbzhang@hnu.edu.cn yinxia@hnu.edu.cn xiongmy@hnu.edu.cn.

Ling HuMolecular Science and Biomedicine Laboratory, State Key Laboratory of Chemo/Biosensing and Chemometrics, College of Chemistry and Chemical Engineering, Collaborative Innovation Center for Chemistry and Molecular Medicine, Hunan University Changsha 41008 P. R. China xbzhang@hnu.edu.cn yinxia@hnu.edu.cn xiongmy@hnu.edu.cn.

Xiao-Bing ZhangMolecular Science and Biomedicine Laboratory, State Key Laboratory of Chemo/Biosensing and Chemometrics, College of Chemistry and Chemical Engineering, Collaborative Innovation Center for Chemistry and Molecular Medicine, Hunan University Changsha 41008 P. R. China xbzhang@hnu.edu.cn yinxia@hnu.edu.cn xiongmy@hnu.edu.cn.ORCID https://orcid.org/0000-0002-4010-0028

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Nonspecific adhesivity of nanoparticles to cells is regarded as a significant issue of nanomedicine, which brings about many serious drawbacks in applications, including low detection sensitivity, non-targeted biotoxicity and poor diagnostic accuracy. Here, we propose for the first time, DNA-decorated semiconductor polymer nanoparticles (SPN-DNAs), whose adhesivity can be significantly alleviated by controlling the density and thickness of DNA layers. This property is demonstrated to be independent of external conditions such as temperature, concentration, incubation time, ionic strength and cell lines. The mechanism of this phenomenon is also discussed. Finally, based on minimized nonspecific adhesivity to cells, a triggered nanoswitch can be constructed to control cellular internalization and drug delivery.

Identifiers

PMID36349005

DOI10.1039/d2ra05172a

PMCPMC9623458

What OpenQuestion holds

Textmetadata

LicenceCC BY-NC

Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.