Evidence map›Paper›PMID 36348973›Full record

ArticleAlzheimer's & dementia (Amsterdam, Netherlands)2022

Sex-specific biomarkers in Alzheimer's disease progression: Framingham Heart Study.

Chunyu Liu, Yi Li, Adaora Nwosu, Ting Fang Alvin Ang, Yulin Liu, Sherral Devine, Rhoda Au, P Murali Doraiswamy

Open access · goldAbstract read
In one paragraph

Article in Alzheimer's & dementia (Amsterdam, Netherlands), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed, 1 pooled it
2.7field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 1 synthesis or guideline pooled it, 18 citations in OpenAlex.

  1. Sex differences inFrontiers in dementia · 2025
    Pooled it
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  11. Review
  12. Reproductive Markers in Alzheimer's Disease Progression: The Framingham Heart Study.The journal of prevention of Alzheimer's disease · 2023
    Article
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  14. Article
  15. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 1 country.

Chunyu LiuDepartment of Biostatistics Boston University School of Public Health Boston Massachusetts USA.
Yi LiDepartment of Biostatistics Boston University School of Public Health Boston Massachusetts USA.
Adaora NwosuDepartments of Psychiatry and Medicine Neurocognitive Disorders Program Duke University School of Medicine Durham North Carolina USA.
Ting Fang Alvin AngFramingham Heart Study Boston University School of Medicine Boston Massachusetts USA.
Yulin LiuFramingham Heart Study Boston University School of Medicine Boston Massachusetts USA.
Sherral DevineFramingham Heart Study Boston University School of Medicine Boston Massachusetts USA.
Rhoda AuFramingham Heart Study Boston University School of Medicine Boston Massachusetts USA.
P Murali DoraiswamyDepartments of Psychiatry and Medicine Neurocognitive Disorders Program Duke University School of Medicine Durham North Carolina USA.
Boston University · USDuke University · USFramingham Heart Study · US

Funding

TBDU19AG068753 · NIA · BOSTON UNIVERSITY MEDICAL CAMPUS · PI Ting Fang Alvin Ang · 2020 to 2026
$42.4M
EPIDEMIOLOGY OF DEMENTIA IN THE FRAMINGHAM STUDYR01AG008122 · NIA · BOSTON UNIVERSITY MEDICAL CAMPUS · PI AU, RHODA, SESHADRI, SUDHA · 1989 to 2015
$14.4M
MRI, Genetics &Cognitive Precursors of AD &DementiaR01AG016495 · NIA · BOSTON UNIVERSITY MEDICAL CAMPUS · PI AU, RHODA · 1999 to 2016
$12.5M
Mitochondrial DNA Copy Number and Sequence Variation in Relation to Age, Alzheimer's Disease Related Phenotypes and Age-related Metabolic TraitsR01AG059727 · NIA · BOSTON UNIVERSITY MEDICAL CAMPUS · PI LIU, CHUNYU, SATIZABAL, CLAUDIA L · 2018 to 2021
$2.6M
Cognitive Heterogeneity in those with high Alzheimer's Disease RiskRF1AG062109 · NIA · BOSTON UNIVERSITY MEDICAL CAMPUS · PI AU, RHODA · 2020 to 2021
$1.8M
Cognitive heterogeneity in those with high Alzheimer's Disease RiskR56AG062109 · NIA · BOSTON UNIVERSITY MEDICAL CAMPUS · PI AU, RHODA · 2018 to 2018
$517k
NHLBI NIH HHS HHSN268201500001CNHLBI NIH HHS HHSN268201500001INIA NIH HHS R01 AG008122NIA NIH HHS R01 AG016495NIA NIH HHS R01 AG059727NIA NIH HHS R56 AG062109NIA NIH HHS RF1 AG062109NIA NIH HHS U19 AG068753
6 · The paper itself

Abstract

Background: Sex differences in Alzheimer's disease (AD) are not well understood. Methods: We performed sex-specific analyses of AD and annualized cognitive decline with clinical and blood biomarker data in participants 60+ years old in the community-based longitudinal Framingham Heart Study Offspring Cohort ( Results: During 11 years of follow-up, women were 96% more likely than men to be diagnosed with clinical AD dementia after adjusting for age and education in the younger age group 60 to 70 years ( Discussion: Our study suggests that both early life and later-life pathological factors may contribute to potential sex differences in incident AD.

Indexed as

abeta 42ADbiomarkerscognition decline

Identifiers

PMID36348973
PMCPMC9633867
OpenAlexW4308678760

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.