Evidence map›Paper›PMID 36348486›Full record

ArticleBMC neurology2022

A rare case report of primary Sjögren's syndrome with clinical characteristics similar to those of CLIPPERS.

ChenLing Lv, FeiYan Zhu, Chao Chen, YunLing Wang, DengJun Guo, ZhenZhong Zhang

Open access · goldAbstract readCase Reports
PubMed Full text at PMC Publisher
In one paragraph

Article in BMC neurology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.1field-weighted citation impact, top 52% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 citations in OpenAlex.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

ChenLing LvDepartment of Neurology, Tongde Hospital of Zhejiang Province, 234 Gucui Road, 310012, Hangzhou, Zhejiang, China.
FeiYan ZhuDepartment of Neurology, Tongde Hospital of Zhejiang Province, 234 Gucui Road, 310012, Hangzhou, Zhejiang, China. zhufeiyan2013@126.com.ORCID http://orcid.org/0000-0002-4276-4522
Chao ChenDepartment of Cardiology, Hangzhou Hospital of Traditional Chinese Medicine, Hangzhou, Zhejiang, China.
YunLing WangDepartment of Neurology, Tongde Hospital of Zhejiang Province, 234 Gucui Road, 310012, Hangzhou, Zhejiang, China.
DengJun GuoDepartment of Neurology, Tongde Hospital of Zhejiang Province, 234 Gucui Road, 310012, Hangzhou, Zhejiang, China.
ZhenZhong ZhangDepartment of Neurology, Tongde Hospital of Zhejiang Province, 234 Gucui Road, 310012, Hangzhou, Zhejiang, China.
Tongde Hospital of Zhejiang Province · CNHangzhou Hospital of Traditional Chinese Medicine · CN

Funding

health and family planning commission of Zhejiang province 2019KY343
6 · The paper itself

Abstract

backgroundPrimary Sjögren's syndrome (pSS) is an autoimmune inflammatory disease characterized by dryness of the eyes, mouth and other mucous membranes. Patients with pSS can also present with extraglandular manifestations, such as pulmonary, kidney and nervous system involvement. Central nervous system (CNS) manifestations have rarely been described in pSS. CASE PRESENTATION: A 33-year-old man was admitted with a one-month history of dizziness, speech disturbance, and walking instability. His brain enhanced magnetic resonance imaging (MRI) showed symmetrical, enhanced "salt-and-pepper-like" speckled lesions in the brainstem, basal ganglia, and subcortical regions, and his diagnosis was considered possible chronic lymphocytic inflammation with pontine perivascular enhancement responsive to steroids (CLIPPERS). Further examination revealed that anti-SSA antibody was positive, and the Schirmer test and labial salivary gland histopathology were abnormal, which supported the diagnosis of pSS.

conclusionpSS is a chronic systemic autoimmune disease that involves neurological complications. This case suggests that CNS lesions of pSS can present with clinical and MRI findings similar to those of CLIPPERS.

Indexed as

Central Nervous System DiseasesSjogren's SyndromeAdultBrainHumansMagnetic Resonance ImagingMalePonsCentral nervous systemCLIPPERSMagnetic resonance imagingPrimary Sjögren′s syndrome

Identifiers

PMID36348486
PMCPMC9641841
OpenAlexW4308569668

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.