ReviewHuman genomics2022
A review on the application of the exposome paradigm to unveil the environmental determinants of age-related diseases.
Review in Human genomics, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
19 citing papers in PubMed, 32 citations in OpenAlex.
- A Comparative Analysis of Aging Across Causes of Death.Evolutionary applications · 2026Article
- Article
- Urinary Organophosphate Esters and Increased Oxidative Stress in Healthy Older Adults: The China BAPE Study.Environment & health (Washington, D.C.) · 2026Article
- Identifying direct risk factors in UK Biobank via simultaneous Bayesian-frequentist model-averaged hypothesis testing using Doublethink.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- Age-Related Human Adaptation to Extreme Climatic Factors and Environmental Conditions.Biology · 2025Article
- Insights into bridging disciplines and building measures from the Gateway Exposome Coordinating Center workshop.Nature aging · 2025Article
- Relationship Between Facial Melasma and Ocular Photoaging Diseases.Medical sciences (Basel, Switzerland) · 2025Article
- Advancing translational exposomics: bridging genome, exposome and personalized medicine.Human genomics · 2025Review
- Inflammaging Markers in the Extremely Cold Climate: A Case Study of Yakutian Population.International journal of molecular sciences · 2024Article
- Classification of Suicide Attempt Risk Using Environmental and Lifestyle Factors in 3 Large Youth Cohorts.JAMA psychiatry · 2024Article
- Shared whole environmental etiology between Alzheimer's disease and age-related macular degeneration.npj aging · 2024Article
- Article
- The science of uncertainty guides fetal-neonatal neurology principles and practice: diagnostic-prognostic opportunities and challenges.Frontiers in neurology · 2024Review
- Editorial: Genome-based nutrition strategies for preventing diet-related chronic diseases: where genes, diet, and food culture meet.Frontiers in nutrition · 2024Article
- Parkinson's Disease is Predominantly a Genetic Disease.Journal of Parkinson's disease · 2024Review
- Article
- Editorial: Healthspan and neural aging: Merging the exposome and one environmental health - From molecular mechanisms to epidemiology.Frontiers in aging neuroscience · 2023Article
- Interdisciplinary fetal-neonatal neurology training applies neural exposome perspectives to neurology principles and practice.Frontiers in neurology · 2023Review
- Article
Corrections and comments
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Authors and funding
5 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Age-related diseases account for almost half of all diseases among adults worldwide, and their incidence is substantially affected by the exposome, which is the sum of all exogenous and endogenous environmental exposures and the human body's response to these exposures throughout the entire lifespan. Herein, we perform a comprehensive review of the epidemiological literature to determine the key elements of the exposome that affect the development of age-related diseases and the roles of aging hallmarks in this process. We find that most exposure assessments in previous aging studies have used a reductionist approach, whereby the effect of only a single environmental factor or a specific class of environmental factors on the development of age-related diseases has been examined. As such, there is a lack of a holistic and unbiased understanding of the effect of multiple environmental factors on the development of age-related diseases. To address this, we propose several research strategies based on an exposomic framework that could advance our understanding-in particular, from a mechanistic perspective-of how environmental factors affect the development of age-related diseases. We discuss the statistical methods and other methods that have been used in exposome-wide association studies, with a particular focus on multiomics technologies. We also address future challenges and opportunities in the realm of multidisciplinary approaches and genome-exposome epidemiology. Furthermore, we provide perspectives on precise public health services for vulnerable populations, public communications, the integration of risk exposure information, and the bench-to-bedside translation of research on age-related diseases.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.