ArticleBMC psychiatry2022
Aberrant interhemispheric functional connectivity in major depressive disorder with and without anhedonia.
Article in BMC psychiatry, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 1 of them a synthesis that pooled it.
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Who cites it
14 citing papers in PubMed, 1 synthesis or guideline pooled it, 25 citations in OpenAlex.
- The conscious processing of emotion in depression disorder: a meta-analysis of neuroimaging studies.Frontiers in psychiatry · 2023Pooled it
- Anhedonia in Depressive Disorder and Schizophrenia: An Overview of Causes, Diagnosis, and Treatment.Medical science monitor : international medical journal of experimental and clinical research · 2025Review
- Altered brain structure age gap estimation in major depressive disorder patients with and without anhedonia: a machine learning-based study.Translational psychiatry · 2025Article
- The characteristics of anhedonia in depression: a review from a clinically oriented perspective.Translational psychiatry · 2025Review
- Individualized resting-state functional connectivity abnormalities unveil two major depressive disorder subtypes with contrasting abnormal patterns of abnormality.Translational psychiatry · 2025Article
- Influence of depression severity on interhemispheric functional integration: an analysis from the REST-meta-MDD database.Brain imaging and behavior · 2025Article
- Abnormal Structure-Function Coupling in Major Depressive Disorder Patients With and Without Anhedonia.Depression and anxiety · 2025Article
- Altered interhemispheric functional connectivity in end-stage renal disease patients receiving hemodialysis without cognitive impairment.Frontiers in neurology · 2025Article
- Decreased low-frequency amplitude of the right caudate nucleus in patients with chronic schizophrenia treated with risperidone combined with clozapine.Frontiers in psychiatry · 2025Article
- Neural substrates of predicting anhedonia symptoms in major depressive disorder via connectome-based modeling.CNS neuroscience & therapeutics · 2024Article
- Alterations of brainstem volume in patients with first-episode and recurrent major depressive disorder.BMC psychiatry · 2023Article
- Altered hippocampal subfield volumes in major depressive disorder with and without anhedonia.BMC psychiatry · 2023Article
- Abnormal functional connectivity of the nucleus accumbens subregions mediates the association between anhedonia and major depressive disorder.BMC psychiatry · 2023Article
- Abnormal voxel-mirrored homotopic connectivity in first-episode major depressive disorder using fMRI: a machine learning approach.Frontiers in psychiatry · 2023Article
Corrections and comments
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Authors and funding
10 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveAnhedonia is a core feature of major depressive disorder (MDD), and as a subtype of depression, MDD with anhedonia may have exceptional neurobiological mechanisms. However, the neuropathology of anhedonia in MDD remains unclear. Thus, this study aimed to investigate the brain functional differences between MDD with and without anhedonia.
methodsA total of 62 individuals including 22 MDD patients with anhedonia, 20 MDD patients without anhedonia, and 20 healthy controls (HCs) were recruited for this study. All participants underwent 3.0-T functional magnetic resonance imaging scan. Voxel-mirrored homotopic connectivity (VMHC) was employed to quantitatively describe bilateral functional connectivity. Analyses of variance (ANOVA) were performed to obtain brain regions with significant differences among three groups and then post hoc tests were calculated for inter-group comparisons.
resultsThe ANOVA revealed significant VMHC differences among three groups in the bilateral middle temporal gyrus (MTG), superior frontal gyrus (SFG), and inferior parietal lobule (IPL) (F = 10.47 ~ 15.09, p < 0.05, AlphaSim corrected). Relative to HCs, MDD with anhedonia showed significantly decreased VMHC in the bilateral MTG (t = -5.368, p < 0.05, AlphaSim corrected), as well as increased VMHC in the bilateral SFG (t = -4.696, p < 0.05, AlphaSim corrected). Compared to MDD without anhedonia, MDD with anhedonia showed significantly decreased VMHC in the bilateral MTG and IPL (t = -5.629 ~ -4.330, p < 0.05, AlphaSim corrected), while increased VMHC in the bilateral SFG (t = 3.926, p < 0.05, AlphaSim corrected). However, no significant difference was found between MDD without anhedonia and HCs.
conclusionThe present findings suggest that MDD with and without anhedonia exhibit different patterns of interhemispheric connectivity. Anhedonia in MDD is related to aberrant interhemispheric connectivity within brain regions involved in the frontal-temporal-parietal circuit.
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