Observational studyBMC cancer2022
Body mass index and incidence of lung cancer in the HUNT study: using observational and Mendelian randomization approaches.
Observational study in BMC cancer, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
8 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Body mass index and lung cancer risk: Pooled analysis of 10 prospective cohort studies in Japan.Cancer science · 2024Pooled it
- Effect Modification by Cofactors in the Impact of Body Mass Index Change on the Risk of Lung Cancer.Cancer science · 2026Article
- Serum Vitamin D Levels Over Time and the Incidence of Atrial Fibrillation in the HUNT Study.Journal of the Endocrine Society · 2025Article
- Survival assessment and pre-diagnostic risk factors for lung cancer incidence: Insights from the Golestan Cohort Study.PloS one · 2025Article
- Serum vitamin D, blood pressure and hypertension risk in the HUNT study using observational and Mendelian randomization approaches.Scientific reports · 2024Observational
- A Retrospective Analysis: Investigating Factors Linked to High Lung-RADS Scores in a Nonsmoking, Non-Family History Population.Diagnostics (Basel, Switzerland) · 2024Article
- Causal relationship between metabolites and embolic stroke: based on Mendelian randomization and metabolomics.Frontiers in neurology · 2024Article
- Mendelian randomization to explore the direct or mediating associations between socioeconomic status and lung cancer.Frontiers in oncology · 2023Article
Corrections and comments
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Authors and funding
6 authors.
Funding
Abstract
backgroundTraditional observational studies have shown an inverse association between body mass index (BMI) and lung cancer risk. Mendelian randomization (MR) analysis using genetic variants as instruments for BMI may clarify the nature of the association.
aimsWe studied the causal association between BMI and lung cancer incidence using observational and MR approaches.
methodsWe followed up 62,453 cancer-free Norwegian adults from 1995-97 (HUNT2) until 2017. BMI at baseline in HUNT2 was classified as < 25.0, 25.0-29.9 and ≥ 30.0 kg/m
resultsDuring a median follow-up of 21.1 years, 1009 participants developed lung cancer including 327 with lung adenocarcinoma. The HRs and 95% CIs for incidence of adenocarcinoma were 0.73 (0.58-0.92) for BMI 25.0-29.9 kg/m
conclusionsOur study suggests that the inverse association between baseline BMI and lung adenocarcinoma in observational analysis may not be causal. More MR studies are needed to confirm our finding of a positive association between BMI and lung adenocarcinoma.
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