Evidence map›Paper›PMID 36348253›Full record

ArticleJournal of endocrinological investigation2023

Effects of hormonal treatment on dermatological outcome in transgender people: a multicentric prospective study (ENIGI).

C Cocchetti, G Castellini, M Maggi, A Romani, L Vignozzi, Y Greenman, M den Heijer, G T'Sjoen, A D Fisher

Open access · hybridFull text readMulticenter Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of endocrinological investigation, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
2.9field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 14 citations in OpenAlex.

  1. Quantitative effects of sex hormones on hair growth and patient satisfaction.The Journal of clinical endocrinology and metabolism · 2026
    Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 4 institutions in 4 countries.

C CocchettiAndrology, Women's Endocrinology and Gender Incongruence Unit, Florence University Hospital, Florence, Italy.
G CastelliniPsychiatric Unit, Department of Health Sciences, University of Florence, Florence, Italy.
M MaggiDepartment of Experimental and Clinical Biomedical Sciences "Mario Serio", University of Florence, 50139, Florence, Italy.
A RomaniAndrology, Women's Endocrinology and Gender Incongruence Unit, Florence University Hospital, Florence, Italy.
L VignozziAndrology, Women's Endocrinology and Gender Incongruence Unit, Florence University Hospital, Florence, Italy.
Y GreenmanInstitute of Endocrinology and Metabolism, Tel Aviv Sourasky Medical Center, Tel Aviv University, Tel Aviv, Israel.
M den HeijerDepartment of Endocrinology and Center of Expertise on Gender Dysphoria, Amsterdam University Medical Center, VUmc, Amsterdam, The Netherlands.
G T'SjoenDepartment of Endocrinology, Center for Sexology and Gender, Ghent University Hospital, Ghent, Belgium.
A D FisherAndrology, Women's Endocrinology and Gender Incongruence Unit, Florence University Hospital, Florence, Italy. afisher@unifi.it.ORCID http://orcid.org/0000-0003-3446-5132
University of Florence · ITAmsterdam University Medical Centers · NLGhent University Hospital · BETel Aviv University · IL

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeThe aim of our study was to assess dermatological changes in transgender people after the start of gender-affirming hormonal treatment (GAHT) and to investigate whether various hormonal preparations differently affect dermatological changes in trans AFAB (assigned female at birth) people.

methodsIn a multicenter prospective study, 484 participants (193 assigned male at birth/AMAB and 291 AFAB) were evaluated at baseline (T0), 6 (T1) and 12 months (T2) after the start of GAHT. Hair growth was assessed by the Ferriman-Gallwey (FG) score, acne by the Global Acne Grading Scale (GAGS), and alopecia by the Norwood Hamilton (NH) score.

resultsIn AFAB people, a significant increase in FG score and NH grade was observed across time, as well as in GAGS score in a subsample of 71 individuals (p < 0.001). Testosterone (T) undecanoate and esters showed a higher increase in hair distribution at T2 vs. T1 as compared to T gel (p < 0.01). T esters showed a significantly higher impact in GAGS score modifications at T1 and at T2 vs. T0 compared to T gel (p = 0.021 and p = 0.003, respectively). In trans AMAB people, a significant decrease of FG score was observed across time (p < 0.001), although 51.3% of individuals still reported an FG score higher than eight after 12 months.

conclusionT treatment increased hair growth, acne and alopecia prevalence in AFAB people, with T undecanoate and esters influencing hair growth more than T gel. Opposite dermatological changes were observed in AMAB people.

Indexed as

Acne VulgarisTransgender PersonsTranssexualismAdolescentAdultAlopeciaFemaleHumansMaleProspective StudiesYoung AdultAcneAlopeciaBody hairDermatological changesGender-affirming hormonal treatmentTransgender

Identifiers

PMID36348253
PMCPMC10023754
OpenAlexW4308527230

What OpenQuestion holds

Textfull text, public
LicenceCC BY
measurements read45
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.