ArticleEuropean journal of trauma and emergency surgery : official publication of the European Trauma Society2023
Visualization of the inflammatory response to injury by neutrophil phenotype categories : Neutrophil phenotypes after trauma.
Article in European journal of trauma and emergency surgery : official publication of the European Trauma Society, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 1 of them a synthesis that pooled it.
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Who cites it
13 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Neutrophil cell surface receptor dynamics following trauma: a systematic review.European journal of trauma and emergency surgery : official publication of the European Trauma Society · 2025Pooled it
- Neutrophil phenotyping reflects injury severity when base excess and lactate remain normal.European journal of trauma and emergency surgery : official publication of the European Trauma Society · 2026Article
- International comparison of neutrophil surface markers after severe trauma is feasible using point of care flowcytometry - results from a pilot study.Inflammation research : official journal of the European Histamine Research Society ... [et al.] · 2026Article
- Injury to the thorax is a dominant contributor to post-traumatic neutrophil mediated inflammatory response.European journal of trauma and emergency surgery : official publication of the European Trauma Society · 2026Article
- High interobserver reliability of neutrophil phenotyping based on visual determination of CD16/CD62L expression patterns.Langenbeck's archives of surgery · 2026Article
- Defining the early systemic neutrophil signature after severe trauma: decreased CD10/CD16 levels on admission precedes metabolic dysregulation.European journal of trauma and emergency surgery : official publication of the European Trauma Society · 2025Article
- Exploratory Study of CD10Scandinavian journal of immunology · 2025Article
- Change in resuscitation influenced development and severity of inflammatory complications in severely injured.European journal of trauma and emergency surgery : official publication of the European Trauma Society · 2025Article
- Exploring the role of systemic inflammation in guiding clinical decision making for geriatric patients with a hip fracture.European journal of trauma and emergency surgery : official publication of the European Trauma Society · 2025Article
- Time sequence of bacterial and fungal pathogens causing infections in trauma patients.Trauma surgery & acute care open · 2025Article
- Neutrophil phenotypes quantify tissue damage caused by major surgery.Frontiers in surgery · 2025Article
- Limited impact of traumatic brain injury on the post-traumatic inflammatory cellular response.European journal of trauma and emergency surgery : official publication of the European Trauma Society · 2024Article
- Identification of neutrophil phenotype categories in geriatric hip fracture patients aids in personalized medicine.OTA international : the open access journal of orthopaedic trauma · 2023Article
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8 authors.
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No grant is acknowledged in the PubMed record.
Abstract
purposeThe risk of infectious complications after trauma is determined by the amount of injury-related tissue damage and the resulting inflammatory response. Recently, it became possible to measure the neutrophil phenotype in a point-of-care setting. The primary goal of this study was to investigate if immunophenotype categories based on visual recognition of neutrophil subsets are applicable to interpret the inflammatory response to trauma. The secondary goal was to correlate these immunophenotype categories with patient characteristics, injury severity and risk of complications.
methodsA cohort study was conducted with patients presented at a level 1 trauma center with injuries of any severity, who routinely underwent neutrophil phenotyping. Data generated by automated point-of-care flow cytometry were prospectively gathered. Neutrophil phenotypes categories were defined by visual assessment of two-dimensional CD16/CD62L dot plots. All patients were categorized in one of the immunophenotype categories. Thereafter, the categories were validated by multidimensional analysis of neutrophil populations, using FlowSOM. All clinical parameters and endpoints were extracted from the trauma registry.
resultsThe study population consisted of 380 patients. Seven distinct immunophenotype Categories (0-6) were defined, that consisted of different neutrophil populations as validated by FlowSOM. Injury severity scores and risk of infectious complications increased with ascending immunophenotype Categories 3-6. Injury severity was similarly low in Categories 0-2.
conclusionThe distribution of neutrophil subsets that were described in phenotype categories is easily recognizable for clinicians at the bedside. Even more, multidimensional analysis demonstrated these categories to be distinct subsets of neutrophils. Identification of trauma patients at risk for infectious complications by monitoring the immunophenotype category is a further improvement of personalized and point-of-care decision-making in trauma care.
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