ArticleScientific reports2022
Finite element modeling of effects of tissue property variation on human optic nerve tethering during adduction.
Article in Scientific reports, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed.
- Optic Disc and Retinal Strain Due to Vertical Duction.Investigative ophthalmology & visual science · 2026Article
- Horizontal Gaze Tolerance and Its Effects on Visual Sensitivity in Glaucoma.Investigative ophthalmology & visual science · 2025Article
- Tensile properties of glaucomatous human sclera, optic nerve, and optic nerve sheath.Biomechanics and modeling in mechanobiology · 2024Article
- Biomechanics Explains Variability of Response of Small Hypertropia to Graded Vertical Rectus Tenotomy.American journal of ophthalmology · 2024Article
- Postmortem Digital Image Correlation and Finite Element Modeling Demonstrate Posterior Scleral Deformations during Optic Nerve Adduction Tethering.Bioengineering (Basel, Switzerland) · 2024Article
- Scanning Laser Ophthalmoscopy Demonstrates Pediatric Optic Disc and Peripapillary Strain During Horizontal Eye Rotation.Current eye research · 2024Article
- Changes in Optic Nerve Head Blood Flow During Horizontal Ocular Duction.Investigative ophthalmology & visual science · 2024Article
- Scanning Laser Ophthalmoscopy Demonstrates Disc and Peripapillary Strain During Horizontal Eye Rotation in Adults.American journal of ophthalmology · 2023Article
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3 authors.
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Abstract
Tractional tethering by the optic nerve (ON) on the eye as it rotates towards the midline in adduction is a significant ocular mechanical load and has been suggested as a cause of ON damage induced by repetitive eye movements. We designed an ocular finite element model (FEM) simulating 6° incremental adduction beyond the initial configuration of 26° adduction that is the observed threshold for ON tethering. This FEM permitted sensitivity analysis of ON tethering using observed material property variations in measured hyperelasticity of the anterior, equatorial, posterior, and peripapillary sclera; and the ON and its sheath. The FEM predicted that adduction beyond the initiation of ON tethering concentrates stress and strain on the temporal side of the optic disc and peripapillary sclera, the ON sheath junction with the sclera, and retrolaminar ON neural tissue. However, some unfavorable combinations of tissue properties within the published ranges imposed higher stresses in these regions. With the least favorable combinations of tissue properties, adduction tethering was predicted to stress the ON junction and peripapillary sclera more than extreme conditions of intraocular and intracranial pressure. These simulations support the concept that ON tethering in adduction could induce mechanical stresses that might contribute to ON damage.
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