Evidence map›Paper›PMID 36347569›Full record

ArticleArchives of disease in childhood2023

Acute postprandial gut hormone, leptin, glucose and insulin responses to resistant starch in obese children: a single blind crossover study.

Jananie Suntharesan, Navoda Atapattu, Eresha Jasinghe, Sagarika Ekanayake, Delpachitra Acharige Gajabahu Harendra de Silva, Gareth Dunseath, Steohan Luzio, Lakdasa Premawardhana

Open access · hybridAbstract read
In one paragraph

Article in Archives of disease in childhood, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.5field-weighted citation impact, top 37% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 4 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 5 institutions in 2 countries.

Jananie SuntharesanEndocrinology, Lady Ridgeway Hospital for Children, Colombo, Sri Lanka.
Navoda AtapattuEndocrinology, Lady Ridgeway Hospital for Children, Colombo, Sri Lanka navodaa@gmail.com.ORCID 0000-0002-3398-2536
Eresha JasingheBiochemistry, Lady Ridgeway Hospital, Colombo, Sri Lanka.
Sagarika EkanayakeBiochemistry, University of Sri Jayawardenepura Department of Medical Education and Health Sciences, Nugegoda, Sri Lanka.
Delpachitra Acharige Gajabahu Harendra de SilvaDepartment of Paediatrics, Faculty of Medicine, University of Colombo, Colombo, Sri Lanka.
Gareth DunseathDiabetes Research Group, Swansea University School of Medicine, Swansea, UK.ORCID 0000-0001-6022-862X
Steohan LuzioDiabetes Research Group, Swansea University School of Medicine, Swansea, UK.
Lakdasa PremawardhanaThyroid Research Group, Cardiff University College of Biomedical and Life Sciences, Cardiff, UK.ORCID 0000-0003-0931-3700
Lady Ridgeway Hospital for Children · LKSwansea University · GBCardiff University · GBUniversity of Colombo · LKUniversity of Sri Jayewardenepura · LK

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionResistant starch (RS) has beneficial effects on postprandial glucose metabolism in both animals and adults. Hitherto, there have been no studies in children of the acute metabolic and hormonal effects of RS-containing meals.

objectivesWe aimed to compare serial plasma glucose, insulin, gut hormone, leptin profiles and satiety scores in obese children after meals containing variable amounts of RS.

methodsThis was a single blind, non-randomised, crossover study of 20 obese children aged 10-14 years old without comorbidities. Three test meals containing rice (M1), rice cooked with coconut oil (M2), rice cooked in coconut oil with lentils (M3) were given in sequence after a 12-hour fast . Blood samples were analysed for glucose (PG), insulin, leptin, glucagon-like polypeptide (GLP) 1, ghrelin and peptide YY (PYY) at appropriate times between 0 and 180 min.

resultsMeal M2 resulted in significantly lower postprandial glucose values compared with meal M1 (maximal incremental glucose, ∆C

conclusionThis study shows that M2, the meal containing RS alone, induced beneficial effects on acute postprandial glucose, insulin and ghrelin concentrations in obese children without diabetes. Acute postprandial satiety scores were not significantly affected by the three meals. TRIAL REGISTRATION NUMBER: SLCTR/2020/007.

Indexed as

InsulinPediatric ObesityBlood GlucoseChildCoconut OilCross-Over StudiesGhrelinGlucagon-Like Peptide 1GlucoseHumansLeptinMealsPeptide YYResistant StarchSingle-Blind MethodBlood GlucoseCoconut OilGhrelinGlucagon-Like Peptide 1GlucoseInsulinLeptinPeptide YYResistant Starchadolescent healthbiochemistryendocrinologyobesitypaediatrics

Identifiers

PMID36347569
PMCPMC9763173
OpenAlexW4308527092

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.