ReviewCMAJ open
Secondary causes of elevated hemoglobin in patients undergoing molecular testing for suspected polycythemia vera in southwestern Ontario: a chart review.
Open access · diamondAbstract readReview
In one paragraph
Review in CMAJ open. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers, 1 of them a synthesis that pooled it.
0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed, 1 pooled it
2.1field-weighted citation impact, top 11% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
10 citing papers in PubMed, 1 synthesis or guideline pooled it, 16 citations in OpenAlex.
- Diagnosis, management, and outcomes of drug-induced erythrocytosis: a systematic review.Blood advances · 2025Pooled it
- Canagliflozin may increase thromboembolic events in males with erythrocytosis but not in females.Blood advances · 2025Trial
- Beyond safety: adverse events and unanticipated advantages of SGLT2 inhibitors.European journal of clinical pharmacology · 2026Review
- Vaping-Induced Erythrocytosis Resolved With Cessation of e-Cigarette Use.Clinical case reports · 2026Article
- JAK2 wild-type erythrocytosis: concept, differential diagnosis, diagnostic steps, and treatment approaches.Hematology. American Society of Hematology. Education Program · 2025Review
- SGLT2i-associated erythrocytosis: closing the evidence gap.Blood advances · 2025Article
- Association Between SGLT2 Inhibitor Use and Change in Hemoglobin Among Adults with Diabetes: A Nationwide Cohort Study.Journal of general internal medicine · 2024Article
- Article
- An Approach to the Investigation of Thrombocytosis: Differentiating between Essential Thrombocythemia and Secondary Thrombocytosis.Advances in hematology · 2024Article
- Prevalence and predictive factors of testosterone-induced erythrocytosis: a retrospective single center study.Frontiers in endocrinology · 2024Observational
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
13 authors at 6 institutions in 3 countries.
Benjamin Chin-YeeDivision of Hematology (B. Chin-Yee, Matyashin, Lazo-Langner, Almanaseer, I. Chin-Yee, Hsia), Department of Medicine, Schulich School of Medicine and Dentistry, Western University; Division of Hematology (B. Chin-Yee, Lazo-Langner, I. Chin-Yee, Hsia), Department of Medicine, London Health Sciences Centre; Department of Pathology and Laboratory Medicine (Cheong, Stuart, Lin, I. Chin-Yee, Sadikovic), Schulich School of Medicine and Dentistry, Western University; Molecular Diagnostic Division (Bhai, Levy, Stuart, Lin, Sadikovic) and Verspeeten Clinical Genome Centre (Bhai, Levy, Sadikovic), London Health Sciences Centre, London, Ont.; Department of Hematology (Kawata), Panasonic Health Insurance Organization, Matsushita Memorial Hospital, Osaka, Japan; Division of Hematology and Oncology (Kawata), Kyoto Prefectural University of Medicine, Kyoto, Japan.
Maxim MatyashinDivision of Hematology (B. Chin-Yee, Matyashin, Lazo-Langner, Almanaseer, I. Chin-Yee, Hsia), Department of Medicine, Schulich School of Medicine and Dentistry, Western University; Division of Hematology (B. Chin-Yee, Lazo-Langner, I. Chin-Yee, Hsia), Department of Medicine, London Health Sciences Centre; Department of Pathology and Laboratory Medicine (Cheong, Stuart, Lin, I. Chin-Yee, Sadikovic), Schulich School of Medicine and Dentistry, Western University; Molecular Diagnostic Division (Bhai, Levy, Stuart, Lin, Sadikovic) and Verspeeten Clinical Genome Centre (Bhai, Levy, Sadikovic), London Health Sciences Centre, London, Ont.; Department of Hematology (Kawata), Panasonic Health Insurance Organization, Matsushita Memorial Hospital, Osaka, Japan; Division of Hematology and Oncology (Kawata), Kyoto Prefectural University of Medicine, Kyoto, Japan.
Ian CheongDivision of Hematology (B. Chin-Yee, Matyashin, Lazo-Langner, Almanaseer, I. Chin-Yee, Hsia), Department of Medicine, Schulich School of Medicine and Dentistry, Western University; Division of Hematology (B. Chin-Yee, Lazo-Langner, I. Chin-Yee, Hsia), Department of Medicine, London Health Sciences Centre; Department of Pathology and Laboratory Medicine (Cheong, Stuart, Lin, I. Chin-Yee, Sadikovic), Schulich School of Medicine and Dentistry, Western University; Molecular Diagnostic Division (Bhai, Levy, Stuart, Lin, Sadikovic) and Verspeeten Clinical Genome Centre (Bhai, Levy, Sadikovic), London Health Sciences Centre, London, Ont.; Department of Hematology (Kawata), Panasonic Health Insurance Organization, Matsushita Memorial Hospital, Osaka, Japan; Division of Hematology and Oncology (Kawata), Kyoto Prefectural University of Medicine, Kyoto, Japan.
Pratibha BhaiDivision of Hematology (B. Chin-Yee, Matyashin, Lazo-Langner, Almanaseer, I. Chin-Yee, Hsia), Department of Medicine, Schulich School of Medicine and Dentistry, Western University; Division of Hematology (B. Chin-Yee, Lazo-Langner, I. Chin-Yee, Hsia), Department of Medicine, London Health Sciences Centre; Department of Pathology and Laboratory Medicine (Cheong, Stuart, Lin, I. Chin-Yee, Sadikovic), Schulich School of Medicine and Dentistry, Western University; Molecular Diagnostic Division (Bhai, Levy, Stuart, Lin, Sadikovic) and Verspeeten Clinical Genome Centre (Bhai, Levy, Sadikovic), London Health Sciences Centre, London, Ont.; Department of Hematology (Kawata), Panasonic Health Insurance Organization, Matsushita Memorial Hospital, Osaka, Japan; Division of Hematology and Oncology (Kawata), Kyoto Prefectural University of Medicine, Kyoto, Japan.
Alejandro Lazo-LangnerDivision of Hematology (B. Chin-Yee, Matyashin, Lazo-Langner, Almanaseer, I. Chin-Yee, Hsia), Department of Medicine, Schulich School of Medicine and Dentistry, Western University; Division of Hematology (B. Chin-Yee, Lazo-Langner, I. Chin-Yee, Hsia), Department of Medicine, London Health Sciences Centre; Department of Pathology and Laboratory Medicine (Cheong, Stuart, Lin, I. Chin-Yee, Sadikovic), Schulich School of Medicine and Dentistry, Western University; Molecular Diagnostic Division (Bhai, Levy, Stuart, Lin, Sadikovic) and Verspeeten Clinical Genome Centre (Bhai, Levy, Sadikovic), London Health Sciences Centre, London, Ont.; Department of Hematology (Kawata), Panasonic Health Insurance Organization, Matsushita Memorial Hospital, Osaka, Japan; Division of Hematology and Oncology (Kawata), Kyoto Prefectural University of Medicine, Kyoto, Japan.
Ala AlmanaseerDivision of Hematology (B. Chin-Yee, Matyashin, Lazo-Langner, Almanaseer, I. Chin-Yee, Hsia), Department of Medicine, Schulich School of Medicine and Dentistry, Western University; Division of Hematology (B. Chin-Yee, Lazo-Langner, I. Chin-Yee, Hsia), Department of Medicine, London Health Sciences Centre; Department of Pathology and Laboratory Medicine (Cheong, Stuart, Lin, I. Chin-Yee, Sadikovic), Schulich School of Medicine and Dentistry, Western University; Molecular Diagnostic Division (Bhai, Levy, Stuart, Lin, Sadikovic) and Verspeeten Clinical Genome Centre (Bhai, Levy, Sadikovic), London Health Sciences Centre, London, Ont.; Department of Hematology (Kawata), Panasonic Health Insurance Organization, Matsushita Memorial Hospital, Osaka, Japan; Division of Hematology and Oncology (Kawata), Kyoto Prefectural University of Medicine, Kyoto, Japan.
Eri KawataDivision of Hematology (B. Chin-Yee, Matyashin, Lazo-Langner, Almanaseer, I. Chin-Yee, Hsia), Department of Medicine, Schulich School of Medicine and Dentistry, Western University; Division of Hematology (B. Chin-Yee, Lazo-Langner, I. Chin-Yee, Hsia), Department of Medicine, London Health Sciences Centre; Department of Pathology and Laboratory Medicine (Cheong, Stuart, Lin, I. Chin-Yee, Sadikovic), Schulich School of Medicine and Dentistry, Western University; Molecular Diagnostic Division (Bhai, Levy, Stuart, Lin, Sadikovic) and Verspeeten Clinical Genome Centre (Bhai, Levy, Sadikovic), London Health Sciences Centre, London, Ont.; Department of Hematology (Kawata), Panasonic Health Insurance Organization, Matsushita Memorial Hospital, Osaka, Japan; Division of Hematology and Oncology (Kawata), Kyoto Prefectural University of Medicine, Kyoto, Japan.
Michael A LevyDivision of Hematology (B. Chin-Yee, Matyashin, Lazo-Langner, Almanaseer, I. Chin-Yee, Hsia), Department of Medicine, Schulich School of Medicine and Dentistry, Western University; Division of Hematology (B. Chin-Yee, Lazo-Langner, I. Chin-Yee, Hsia), Department of Medicine, London Health Sciences Centre; Department of Pathology and Laboratory Medicine (Cheong, Stuart, Lin, I. Chin-Yee, Sadikovic), Schulich School of Medicine and Dentistry, Western University; Molecular Diagnostic Division (Bhai, Levy, Stuart, Lin, Sadikovic) and Verspeeten Clinical Genome Centre (Bhai, Levy, Sadikovic), London Health Sciences Centre, London, Ont.; Department of Hematology (Kawata), Panasonic Health Insurance Organization, Matsushita Memorial Hospital, Osaka, Japan; Division of Hematology and Oncology (Kawata), Kyoto Prefectural University of Medicine, Kyoto, Japan.
Alan StuartDivision of Hematology (B. Chin-Yee, Matyashin, Lazo-Langner, Almanaseer, I. Chin-Yee, Hsia), Department of Medicine, Schulich School of Medicine and Dentistry, Western University; Division of Hematology (B. Chin-Yee, Lazo-Langner, I. Chin-Yee, Hsia), Department of Medicine, London Health Sciences Centre; Department of Pathology and Laboratory Medicine (Cheong, Stuart, Lin, I. Chin-Yee, Sadikovic), Schulich School of Medicine and Dentistry, Western University; Molecular Diagnostic Division (Bhai, Levy, Stuart, Lin, Sadikovic) and Verspeeten Clinical Genome Centre (Bhai, Levy, Sadikovic), London Health Sciences Centre, London, Ont.; Department of Hematology (Kawata), Panasonic Health Insurance Organization, Matsushita Memorial Hospital, Osaka, Japan; Division of Hematology and Oncology (Kawata), Kyoto Prefectural University of Medicine, Kyoto, Japan.
Hanxin LinDivision of Hematology (B. Chin-Yee, Matyashin, Lazo-Langner, Almanaseer, I. Chin-Yee, Hsia), Department of Medicine, Schulich School of Medicine and Dentistry, Western University; Division of Hematology (B. Chin-Yee, Lazo-Langner, I. Chin-Yee, Hsia), Department of Medicine, London Health Sciences Centre; Department of Pathology and Laboratory Medicine (Cheong, Stuart, Lin, I. Chin-Yee, Sadikovic), Schulich School of Medicine and Dentistry, Western University; Molecular Diagnostic Division (Bhai, Levy, Stuart, Lin, Sadikovic) and Verspeeten Clinical Genome Centre (Bhai, Levy, Sadikovic), London Health Sciences Centre, London, Ont.; Department of Hematology (Kawata), Panasonic Health Insurance Organization, Matsushita Memorial Hospital, Osaka, Japan; Division of Hematology and Oncology (Kawata), Kyoto Prefectural University of Medicine, Kyoto, Japan.
Ian Chin-YeeDivision of Hematology (B. Chin-Yee, Matyashin, Lazo-Langner, Almanaseer, I. Chin-Yee, Hsia), Department of Medicine, Schulich School of Medicine and Dentistry, Western University; Division of Hematology (B. Chin-Yee, Lazo-Langner, I. Chin-Yee, Hsia), Department of Medicine, London Health Sciences Centre; Department of Pathology and Laboratory Medicine (Cheong, Stuart, Lin, I. Chin-Yee, Sadikovic), Schulich School of Medicine and Dentistry, Western University; Molecular Diagnostic Division (Bhai, Levy, Stuart, Lin, Sadikovic) and Verspeeten Clinical Genome Centre (Bhai, Levy, Sadikovic), London Health Sciences Centre, London, Ont.; Department of Hematology (Kawata), Panasonic Health Insurance Organization, Matsushita Memorial Hospital, Osaka, Japan; Division of Hematology and Oncology (Kawata), Kyoto Prefectural University of Medicine, Kyoto, Japan.
Bekim SadikovicDivision of Hematology (B. Chin-Yee, Matyashin, Lazo-Langner, Almanaseer, I. Chin-Yee, Hsia), Department of Medicine, Schulich School of Medicine and Dentistry, Western University; Division of Hematology (B. Chin-Yee, Lazo-Langner, I. Chin-Yee, Hsia), Department of Medicine, London Health Sciences Centre; Department of Pathology and Laboratory Medicine (Cheong, Stuart, Lin, I. Chin-Yee, Sadikovic), Schulich School of Medicine and Dentistry, Western University; Molecular Diagnostic Division (Bhai, Levy, Stuart, Lin, Sadikovic) and Verspeeten Clinical Genome Centre (Bhai, Levy, Sadikovic), London Health Sciences Centre, London, Ont.; Department of Hematology (Kawata), Panasonic Health Insurance Organization, Matsushita Memorial Hospital, Osaka, Japan; Division of Hematology and Oncology (Kawata), Kyoto Prefectural University of Medicine, Kyoto, Japan.
Cyrus HsiaDivision of Hematology (B. Chin-Yee, Matyashin, Lazo-Langner, Almanaseer, I. Chin-Yee, Hsia), Department of Medicine, Schulich School of Medicine and Dentistry, Western University; Division of Hematology (B. Chin-Yee, Lazo-Langner, I. Chin-Yee, Hsia), Department of Medicine, London Health Sciences Centre; Department of Pathology and Laboratory Medicine (Cheong, Stuart, Lin, I. Chin-Yee, Sadikovic), Schulich School of Medicine and Dentistry, Western University; Molecular Diagnostic Division (Bhai, Levy, Stuart, Lin, Sadikovic) and Verspeeten Clinical Genome Centre (Bhai, Levy, Sadikovic), London Health Sciences Centre, London, Ont.; Department of Hematology (Kawata), Panasonic Health Insurance Organization, Matsushita Memorial Hospital, Osaka, Japan; Division of Hematology and Oncology (Kawata), Kyoto Prefectural University of Medicine, Kyoto, Japan cyrus.hsia@lhsc.on.ca.
London Health Sciences Centre · CAKyoto Prefectural University of Medicine · JPPanasonic (Japan) · JPMatsushita Memorial Hospital · JPNippon Sheet Glass (Italy) · ITWestern University · CA
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundMolecular testing for
methodsWe reviewed charts of all consecutive patients investigated for erythrocytosis (hemoglobin > 160 g/L for women, > 165 g/L for men) with
resultsA total of 891 patients with erythrocytosis underwent
interpretationUse of SGLT2 inhibitors may be a common and underrecognized secondary cause of elevated hemoglobin levels in patients investigated for erythrocytosis. Our findings underscore the importance of a detailed medical history to support judicious use of molecular testing, in adherence with the current guideline on the investigation of erythrocytosis.
Indexed as
PolycythemiaPolycythemia VeraSodium-Glucose Transporter 2 InhibitorsFemaleHemoglobinsHumansMaleMolecular Diagnostic TechniquesOntarioHemoglobinsSodium-Glucose Transporter 2 Inhibitors
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