Evidence map›Paper›PMID 36347551›Full record

ArticleInvestigative and clinical urology2022

Prognostic value of the endothelial activation and stress index in patients with upper tract urothelial cancer undergoing radical nephroureterectomy.

Jin Seok Gu, Ji Won Ryu, Seong Hyeon Yu, Ho Seok Chung, Jun Eul Hwang, Woo Kyun Bae, Ja Yoon Ku, Chan Ho Lee, Hong Koo Ha, Seung Il Jung and 2 more

Open access · diamondAbstract read
In one paragraph

Article in Investigative and clinical urology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
2.0field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 11 citations in OpenAlex.

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  6. EASIX (endothelial activation and stress index) predicts mortality in patients with coronary artery disease.Clinical research in cardiology : official journal of the German Cardiac Society · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 4 institutions in 1 country.

Jin Seok GuDepartment of Urology, Chonnam National University Medical School, Hwasun, Korea.ORCID 0000-0002-9282-2436
Ji Won RyuDepartment of Urology, Chonnam National University Medical School, Hwasun, Korea.ORCID 0000-0001-6622-3395
Seong Hyeon YuDepartment of Urology, Chonnam National University Medical School, Hwasun, Korea.ORCID 0000-0002-1761-2025
Ho Seok ChungDepartment of Urology, Chonnam National University Medical School, Hwasun, Korea.ORCID 0000-0001-9883-1539
Jun Eul HwangDepartment of Hemato-Oncology, Chonnam National University Medical School, Hwasun, Korea.ORCID 0000-0002-3768-4149
Woo Kyun BaeDepartment of Hemato-Oncology, Chonnam National University Medical School, Hwasun, Korea.ORCID 0000-0003-0267-1943
Ja Yoon KuDepartment of Urology, Dongnam Institute of Radiological & Medical Sciences, Busan, Korea.ORCID 0000-0003-3460-9386
Chan Ho LeeDepartment of Urology, Inje University School of Medicine, Busan, Korea.ORCID 0000-0002-7750-6806
Hong Koo HaDepartment of Urology, Pusan National University School of Medicine, Busan, Korea.ORCID 0000-0002-8240-7765
Seung Il JungDepartment of Urology, Chonnam National University Medical School, Hwasun, Korea.ORCID 0000-0003-4864-8175
Eu Chang HwangDepartment of Urology, Chonnam National University Medical School, Hwasun, Korea. urohwang@gmail.com.ORCID 0000-0002-2031-124X
Dong Deuk KwonDepartment of Urology, Chonnam National University Medical School, Hwasun, Korea.ORCID 0000-0002-1068-3883
Chonnam National University Hwasun Hospital · KRDongnam Institute of Radiological & Medical Sciences · KRInje University · KRPusan National University · KR

Funding

Chonnam National University Hwasun Hospital HCRI21026
6 · The paper itself

Abstract

purposeThe relationship with endothelial activation and stress index (EASIX), which represents the degree of endothelial dysfunction, is unwell known in upper tract urothelial carcinoma (UTUC). The present study aims to assess the prognostic value of the EASIX for recurrence-free survival (RFS) and overall survival (OS) in patients with UTUC who underwent radical nephroureterectomy (RNU). MATERIALS AND

methodsWe retrospectively reviewed the clinical data of 627 patients with UTUC who underwent RNU without neoadjuvant chemotherapy at three hospitals between 2002 and 2019. EASIX scores were calculated using the formula "serum lactate dehydrogenase (U/L)×creatinine (mg/dL)/platelet count (10

resultsAmong 627 patients, 380 were finally analyzed. Using maximally selected log-rank statistics, the optimal EASIX cutoff value was 1.27 on the log

conclusionsEASIX score may represent endothelial dysfunction in patients with UTUC and may serve as a readily available prognostic factor for oncologic outcomes.

Indexed as

Carcinoma, Transitional CellUrinary Bladder NeoplasmsHumansNephroureterectomyPrognosisRetrospective StudiesBlood plateletsCarcinoma, transitional cellCreatinineLactate dehydrogenasePrognosis

Identifiers

PMID36347551
PMCPMC9643726
OpenAlexW4308681944

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.