Evidence map›Paper›PMID 36347523›Full record

ArticleHIV medicine2022

Late diagnosis of HIV: An updated consensus definition.

Sara Croxford, Annemarie Rinder Stengaard, Johanna Brännström, Lauren Combs, Nikos Dedes, Enrico Girardi, Sophie Grabar, Ole Kirk, Giorgi Kuchukhidze, Jeffrey V Lazarus and 9 more

Open access · hybridAbstract readConsensus Statement
In one paragraph

Article in HIV medicine, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 57 papers.

0numbers the graph read from it
0cells of the map it votes in
57citing papers in PubMed
7.3field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

57 citing papers in PubMed, 78 citations in OpenAlex.

  1. Trial
  2. Review
  3. Multi-country study on the impact of a revised consensus definition of late HIV diagnosis, Europe, 2022 to 2023.Euro surveillance : bulletin Europeen sur les maladies transmissibles = European communicable disease bulletin · 2026
    Article
  4. [Missed opportunities in HIV detection: experience in a referral hospital].Revista espanola de quimioterapia : publicacion oficial de la Sociedad Espanola de Quimioterapia · 2026
    Observational
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors at 13 institutions in 9 countries.

Sara CroxfordUK Health Security Agency, London, UK.
Annemarie Rinder StengaardCentre of Excellence for Health, Immunity and Infections - CHIP, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark.
Johanna BrännströmInstitution of Medicine, Karolinska Institute, Karolinska University Hospital Huddinge, Stockholm, Sweden.ORCID 0000-0001-7684-8591
Lauren CombsCentre of Excellence for Health, Immunity and Infections - CHIP, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark.ORCID 0000-0002-7168-5161
Nikos DedesEuroTEST Steering Committee, Copenhagen, Denmark.
Enrico GirardiNational Institute for Infectious Diseases "Lazzaro Spallanzani" IRCCS, Rome, Italy.ORCID 0000-0001-8182-5896
Sophie GrabarSorbonne Université, INSERM, Institut Pierre Louis d'épidémiologie et de Santé Publique, Paris, France.ORCID 0000-0002-4816-4261
Ole KirkCentre of Excellence for Health, Immunity and Infections - CHIP, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark.
Giorgi KuchukhidzeWorld Health Organization Regional Office for Europe, Copenhagen, Denmark.
Jeffrey V LazarusEuroTEST Steering Committee, Copenhagen, Denmark.ORCID 0000-0001-9618-2299
Teymur NooriEuropean Centre for Disease Prevention and Control, Stockholm, Sweden.ORCID 0000-0002-8935-749X
Anastasia PharrisEuropean Centre for Disease Prevention and Control, Stockholm, Sweden.
Dorthe RabenCentre of Excellence for Health, Immunity and Infections - CHIP, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark.
Jürgen K RockstrohEuroTEST Steering Committee, Copenhagen, Denmark.
Daniel SimõesEuroTEST Steering Committee, Copenhagen, Denmark.
Ann K SullivanUK Health Security Agency, London, UK.
Dominique Van BeckhovenDepartment of Epidemiology and Public Health, Sciensano, Brussels, Belgium.ORCID 0000-0003-0821-2756
Valerie C DelpechUK Health Security Agency, London, UK.ORCID 0000-0002-9952-8109
EuroTEST HIV Late Diagnosis Definition Working Group
University of Copenhagen · DKEuropean Centre for Disease Prevention and Control · SEUK Health Security Agency · GBBarcelona Institute for Global Health · ESChelsea and Westminster Hospital NHS Foundation Trust · GBEuropean Organisation for Research and Treatment of Cancer · BEi3S - Instituto de Investigação e Inovação em Saúde, Universidade do Porto · PTInserm · FRIstituto Nazionale per le Malattie Infettive Lazzaro Spallanzani · ITKarolinska University Hospital · SESciensano (Belgium) · BEUniversity Hospital Bonn · DEWorld Health Organization Regional Office for Europe · DK

Funding

World Health Organization 001
6 · The paper itself

Abstract

introductionIn recent years, HIV testing frequency has increased, resulting in more people being diagnosed during seroconversion with a temporarily low CD4 count. Using the current consensus definition of late HIV presentation ('presenting for care with a CD4 count < 350 cells/μL or an AIDS-defining event, regardless of CD4 count') these individuals would be incorrectly assigned as being diagnosed late.

methodsIn spring 2022, a European expert group convened to revise the current late HIV presentation consensus definition. A survey on data availability to apply this revised definition was sent to nominated European focal points responsible for HIV surveillance (n = 53).

resultsExperts agreed that the updated definition should refer to late HIV diagnosis rather than presentation and include the following addition: People with evidence of recent infection should be reclassified as 'not late', with evidence of recent infection considered hierarchically. The individual must have: (i) laboratory evidence of recent infection; (ii) a last negative HIV test within 12 months of diagnosis; or (iii) clinical evidence of acute infection. People with evidence of being previously diagnosed abroad should be excluded. A total of 18 countries responded to the survey; 83% reported capturing CD4 count and/or AIDS at diagnosis through national surveillance, 67% captured last negative test and/or previous HIV diagnosis, 61% captured seroconversion illness at diagnosis and 28% captured incident antibody results.

conclusionsAccurate data on late diagnosis are important to describe the effects of testing programmes. Reclassification of individuals with recent infection will help to better identify populations most at risk of poor HIV outcomes and areas for intervention.

Indexed as

Acquired Immunodeficiency SyndromeHIV InfectionsCD4 Lymphocyte CountDelayed DiagnosisHumansRisk FactorsdefinitiondiagnosisHIVlate presentationmonitoring

Identifiers

PMID36347523
PMCPMC10100195
OpenAlexW4308559035

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.