ArticleBrain, behavior, and immunity2023
Socioeconomic and race/ethnic differences in immunosenescence: Evidence from the Health and Retirement Study.
Article in Brain, behavior, and immunity, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers, 2 of them syntheses that pooled it.
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Who cites it
36 citing papers in PubMed, 2 syntheses or guidelines pooled it, 38 citations in OpenAlex.
- Rethinking immune studies: population-level immune variations and the path forward.The journals of gerontology. Series A, Biological sciences and medical sciences · 2026Pooled it
- Peripheral immune function and Alzheimer's disease: a living systematic review and critical appraisal.Molecular psychiatry · 2024Pooled it
- Thymic Involution and Function in People With HIV and General Population Controls: A Cross-Sectional Analysis From Two Danish Cohort Studies.Aging cell · 2026Article
- Associations between immunosenescence and domain-specific cognition in the Health and Retirement Study Harmonized Cognitive Assessment Protocol.BMC biology · 2026Article
- Peripheral immunosenescence biomarkers and longitudinal cognitive decline: a large population-based study.npj aging · 2026Article
- CMV titer associations with cognition and the plasma proteome implicate FLT1 and neurovascular mechanisms as potential moderators.Journal of neuroinflammation · 2026Article
- Age-associated changes in major lymphocyte subsets and sex-specific patterns in healthy Chinese adults.Scientific reports · 2026Article
- Pooled analyses of Clostridioides difficile vaccine trials identify baseline predictors for vaccine response.Scientific reports · 2026Article
- Erzhi pills: a potential aging-modulating agent targeting immunosenescence in mice.Biogerontology · 2026Article
- T cell dysfunction associated with repeated CAR-T cell manufacturing failure following prolonged bispecific antibody exposure: a case report.Leukemia research reports · 2026Article
- Methodological innovations in studying marginalized populations in research on neurodegeneration and ageing.Frontiers in aging neuroscience · 2026Review
- Age-related changes in the immune system and challenges for the development of age-specific vaccines.Annals of medicine · 2025Review
- Life course socioeconomic disadvantage and persistent infection burden: Links to cellular immunosenescence in U.S. young adults.Social science & medicine (1982) · 2025Article
- Advancing multiple sclerosis management in older adults.Nature reviews. Neurology · 2025Article
- Toward precision interventions and metrics of inflammaging.Nature aging · 2025Review
- Health impact of a hypothetical intervention on immune burden of cytomegalovirus (CMV) among older adults in the US: a prospective analysis of the Health and Retirement Study Cohort.Lancet regional health. Americas · 2025Article
- The aging immune system and all-cause mortality in older americans: differences across sex and race/ethnicity.Immunity & ageing : I & A · 2025Article
- Social disadvantage accelerates aging.Nature medicine · 2025Article
- Social relationships and immune aging in early midlife: Evidence from the National Longitudinal Study of Adolescent to Adult Health.Brain, behavior, & immunity - health · 2025Article
- Compositional analysis of lymphocytes and their relationship with health outcomes: findings from the health and retirement study.Immunity & ageing : I & A · 2025Article
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4 authors at 1 institution in 1 country.
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Abstract
backgroundThe COVID-19 pandemic has highlighted the urgent need to understand variation in immunosenescence at the population-level. Thus far, population patterns of immunosenescence have not well described.
methodsWe characterized measures of immunosenescence from the 2016 Venous Blood Study from the nationally representative U.S Health and Retirement Study (HRS) of individuals ages 50 years and older.
resultsMedian values of the CD8+:CD4+, EMRA:Naïve CD4+ and EMRA:Naïve CD8+ ratios were higher among older participants and were lower in those with additional educational attainment. Generally, minoritized race and ethnic groups had immune markers suggestive of a more aged immune profile: Hispanics had a CD8+:CD4+ median value of 0.37 (95 % CI: 0.35, 0.39) compared to 0.30 in non-Hispanic Whites (95 % CI: 0.29, 0.31). Non-Hispanic Blacks had the highest median value of the EMRA:Naïve CD4+ ratio (0.08; 95 % CI: 0.07, 0.09) compared to non-Hispanic Whites (0.03; 95 % CI: 0.028, 0.033). In regression analyses, race/ethnicity and education were associated with large differences in the immune ratio measures after adjustment for age and sex.
conclusionsLower educational attainment and minoritized racial ethnic status were associated with higher levels of immunosenescence. This population variation may have important implications for both risk of age-related disease and vulnerability to emerging pathogens (e.g., SARS-CoV-2).
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