Evidence map›Paper›PMID 36347230›Full record

ArticleCurrent biology : CB2022

Targeted secretion: Myosin V delivers vesicles through formin condensates.

Katherine C Jacobs, Amy S Gladfelter, Daniel J Lew

Abstract readComment
PubMed Publisher
In one paragraph

Article in Current biology : CB, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

3 authors.

Katherine C JacobsDepartment of Genetics and Human Genetics Institute of New Jersey, Rutgers University, Piscataway, NJ 08854, USA.
Amy S GladfelterBiology Department, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.
Daniel J LewDepartment of Pharmacology and Cancer Biology, Duke University, Durham, NC 27705, USA. Electronic address: Daniel.lew@duke.edu.

Funding

Studies on cell polarity, chemotropism, and cell cycle controlR35GM122488 · NIGMS · MASSACHUSETTS INSTITUTE OF TECHNOLOGY · PI DANIEL J LEW · 2017 to 2026
$6.9M
6 · The paper itself

Abstract

Secretory vesicles are often delivered to very specific targets, like pre-synaptic terminals or cell tips, to focus exocytosis. New work suggests that a biomolecular condensate focuses actin filaments that deliver incoming vesicles through the condensate to the plasma membrane.

Indexed as

Myosin Type VActin CytoskeletonActinsExocytosisForminsSecretory VesiclesActinsForminsMyosin Type V

Identifiers

PMID36347230

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.