Evidence map›Paper›PMID 36347077›Full record

ArticleBiosensors & bioelectronics2023

A high-throughput fully automatic biosensing platform for efficient COVID-19 detection.

Guoguang Rong, Yuqiao Zheng, Xiangqing Li, Mengzhun Guo, Yi Su, Sumin Bian, Bobo Dang, Yin Chen, Yanjun Zhang, Linhai Shen and 5 more

Open access · greenAbstract read
In one paragraph

Article in Biosensors & bioelectronics, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
2.0field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 25 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 4 institutions in 1 country.

Guoguang RongCenBRAIN Neurotech, School of Engineering, Westlake University, 600 Dunyu Road, Xihu District, Hangzhou, Zhejiang, 310030, China; School of Engineering, Westlake University, 600 Dunyu Road, Xihu District, Hangzhou, Zhejiang, 310030, China; Institute of Advanced Study, Westlake Institute for Advanced Study, Hangzhou, Zhejiang, 310024, China.
Yuqiao ZhengCenBRAIN Neurotech, School of Engineering, Westlake University, 600 Dunyu Road, Xihu District, Hangzhou, Zhejiang, 310030, China; School of Engineering, Westlake University, 600 Dunyu Road, Xihu District, Hangzhou, Zhejiang, 310030, China; Institute of Advanced Study, Westlake Institute for Advanced Study, Hangzhou, Zhejiang, 310024, China.
Xiangqing LiSchool of Engineering, Westlake University, 600 Dunyu Road, Xihu District, Hangzhou, Zhejiang, 310030, China; Institute of Advanced Study, Westlake Institute for Advanced Study, Hangzhou, Zhejiang, 310024, China.
Mengzhun GuoKey Laboratory of Structural Biology of Zhejiang Province, School of Life Sciences, Westlake, University, Hangzhou, Zhejiang, 310030, China; Center for Infectious Disease Research, Westlake Laboratory of Life Sciences and Biomedicine, Hangzhou, Zhejiang, 310030, China; Institute of Biology, Westlake Institute for Advanced Study, Hangzhou, Zhejiang, 310030, China.
Yi SuCenBRAIN Neurotech, School of Engineering, Westlake University, 600 Dunyu Road, Xihu District, Hangzhou, Zhejiang, 310030, China; School of Engineering, Westlake University, 600 Dunyu Road, Xihu District, Hangzhou, Zhejiang, 310030, China; Institute of Advanced Study, Westlake Institute for Advanced Study, Hangzhou, Zhejiang, 310024, China.
Sumin BianCenBRAIN Neurotech, School of Engineering, Westlake University, 600 Dunyu Road, Xihu District, Hangzhou, Zhejiang, 310030, China; School of Engineering, Westlake University, 600 Dunyu Road, Xihu District, Hangzhou, Zhejiang, 310030, China; Institute of Advanced Study, Westlake Institute for Advanced Study, Hangzhou, Zhejiang, 310024, China.
Bobo DangKey Laboratory of Structural Biology of Zhejiang Province, School of Life Sciences, Westlake, University, Hangzhou, Zhejiang, 310030, China; Center for Infectious Disease Research, Westlake Laboratory of Life Sciences and Biomedicine, Hangzhou, Zhejiang, 310030, China; Institute of Biology, Westlake Institute for Advanced Study, Hangzhou, Zhejiang, 310030, China.
Yin ChenZhejiang Provincial Center for Disease Control and Prevention, 3399 Binsheng Road, Hangzhou, Zhejiang, 310051, China.
Yanjun ZhangZhejiang Provincial Center for Disease Control and Prevention, 3399 Binsheng Road, Hangzhou, Zhejiang, 310051, China.
Linhai ShenHangzhou Center for Disease Control and Prevention, 568 Mingshi Road, Jianggan District, Hangzhou, Zhejiang, 310021, China.
Hui JinHangzhou Center for Disease Control and Prevention, 568 Mingshi Road, Jianggan District, Hangzhou, Zhejiang, 310021, China.
Renhong YanKey Laboratory of Structural Biology of Zhejiang Province, School of Life Sciences, Westlake, University, Hangzhou, Zhejiang, 310030, China; Center for Infectious Disease Research, Westlake Laboratory of Life Sciences and Biomedicine, Hangzhou, Zhejiang, 310030, China.
Liaoyong WenSchool of Engineering, Westlake University, 600 Dunyu Road, Xihu District, Hangzhou, Zhejiang, 310030, China; Institute of Advanced Study, Westlake Institute for Advanced Study, Hangzhou, Zhejiang, 310024, China.
Peixi ZhuCollege of Pharmaceutical Sciences, Zhejiang University of Technology, Hangzhou, Zhejiang, 310014, China.
Mohamad SawanCenBRAIN Neurotech, School of Engineering, Westlake University, 600 Dunyu Road, Xihu District, Hangzhou, Zhejiang, 310030, China; School of Engineering, Westlake University, 600 Dunyu Road, Xihu District, Hangzhou, Zhejiang, 310030, China; Institute of Advanced Study, Westlake Institute for Advanced Study, Hangzhou, Zhejiang, 310024, China. Electronic address: sawan@westlake.edu.cn.
Westlake University · CNHangzhou Center for Disease Control and Prevention · CNZhejiang Center for Disease Control and Prevention · CNZhejiang University of Technology · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

We propose a label-free biosensor based on a porous silicon resonant microcavity and localized surface plasmon resonance. The biosensor detects SARS-CoV-2 antigen based on engineered trimeric angiotensin converting enzyme-2 binding protein, which is conserved across different variants. Robotic arms run the detection process including sample loading, incubation, sensor surface rinsing, and optical measurements using a portable spectrometer. Both the biosensor and the optical measurement system are readily scalable to accommodate testing a wide range of sample numbers. The limit of detection is 100 TCID

Indexed as

Biosensing TechniquesCOVID-19Optical DevicesHumansSARS-CoV-2Surface Plasmon ResonanceAutomatic detectionBiosensorCOVID-19High throughputLocalized surface plasmon resonance (LSPR)SARS-CoV-2

Identifiers

PMID36347077
PMCPMC9630290
OpenAlexW4308456503

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.