Evidence map›Paper›PMID 36346844›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2022

Porphyrin nanoemulsion for antimicrobial photodynamic therapy: effective delivery to inactivate biofilm-related infections.

Hilde Harb Buzzá, Fernanda Alves, Ana Julia Barbosa Tomé, Juan Chen, Giulia Kassab, Jiachuan Bu, Vanderlei Salvador Bagnato, Gang Zheng, Cristina Kurachi

Abstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed.

  1. Article
  2. Article
  3. Review
  4. Review
  5. Article
  6. Article
  7. Article
  8. Inhibition of Biofilm Formation inInternational journal of molecular sciences · 2024
    Article
  9. Article
  10. Review
  11. Photodynamic Eradication ofPharmaceutics · 2023
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Hilde Harb BuzzáSao Carlos Institute of Physics, University of Sao Paulo, Sao Carlos, 13566-590, Brazil.
Fernanda AlvesSao Carlos Institute of Physics, University of Sao Paulo, Sao Carlos, 13566-590, Brazil.
Ana Julia Barbosa ToméSao Carlos Institute of Physics, University of Sao Paulo, Sao Carlos, 13566-590, Brazil.
Juan ChenPrincess Margaret Cancer Centre, University Health Network, Toronto, Ontario, M5G 1L7, Canada.
Giulia KassabSao Carlos Institute of Physics, University of Sao Paulo, Sao Carlos, 13566-590, Brazil.ORCID 0000-0002-9055-7763
Jiachuan BuPrincess Margaret Cancer Centre, University Health Network, Toronto, Ontario, M5G 1L7, Canada.
Vanderlei Salvador BagnatoSao Carlos Institute of Physics, University of Sao Paulo, Sao Carlos, 13566-590, Brazil.ORCID 0000-0003-4833-239X
Gang ZhengPrincess Margaret Cancer Centre, University Health Network, Toronto, Ontario, M5G 1L7, Canada.ORCID 0000-0002-0705-7398
Cristina KurachiSao Carlos Institute of Physics, University of Sao Paulo, Sao Carlos, 13566-590, Brazil.ORCID 0000-0001-7175-5337

Funding

Canadian Institute of Health Research FDN154326
6 · The paper itself

Abstract

The management of biofilm-related infections is a challenge in healthcare, and antimicrobial photodynamic therapy (aPDT) is a powerful tool that has demonstrated a broad-spectrum activity. Nanotechnology has been used to increase the aPDT effectiveness by improving the photosensitizer's delivery properties. NewPS is a simple, versatile, and safe surfactant-free nanoemulsion with a porphyrin salt shell encapsulating a food-grade oil core with promising photodynamic action. This study evaluated the use of NewPS for aPDT against microorganisms in planktonic, biofilm, and in vivo models of infected wounds. First, the potential of NewPS-mediated aPDT to inactivate

Indexed as

Anti-Infective AgentsPhotochemotherapyPorphyrinsAnimalsAnti-Bacterial AgentsBiofilmsMicePhotosensitizing AgentsStaphylococcus aureusAnti-Bacterial AgentsAnti-Infective AgentsPhotosensitizing AgentsPorphyrinsantimicrobial photodynamic therapybiofilmnanoemulsionStaphylococcus aureusStreptococcus pneumoniae

Identifiers

PMID36346844
PMCPMC9674234

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.